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  4. Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit

Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit

  • 中文名称：
    大鼠晚期糖基化终产物特异性受体(AGER)酶联免疫试剂盒
  • 货号：
    CSB-EL001441RA
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        晚期糖基化终产物特异性受体 (AGER) 是一种在炎症、氧化应激和细胞死亡的调节中起重要作用的受体。它在细胞表面表达并与糖基化过程中产生的晚期糖基化终产物 (AGEs) 结合。已发现 AGER 参与多种生理过程，例如伤口愈合、血管生成和免疫反应。此外，它已被确定为糖尿病、肥胖症和癌症等疾病治疗干预的潜在靶点。
        j9九游会登录入口首页生物所提供的Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit属于ELISA检测试剂盒，采用双抗夹心法定量检测大鼠血清、血浆,组织匀浆样本中的AGER，其灵敏度为j9九游会登录入口首页生物所提供的7.81 pg/mL，检测范围为31.25 pg/mL-2000 pg/mL。
     
  • 别名：
    Ager ELISA Kit; Rage ELISA Kit; Advanced glycosylation end product-specific receptor ELISA Kit; Receptor for advanced glycosylation end products ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
    serum, plasma,tissue homogenates
  • 检测范围：
    31.25 pg/mL-2000 pg/mL
  • 灵敏度：
    7.81 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
        最新研究发现，AGER基因的多态性可能与各种疾病的发生有关，包括糖尿病、肺炎、慢性阻塞性肺病等。此外，AGER的表达也与肺癌、乳腺癌、胃癌等肿瘤的发生和发展有关。
     
  • 功能：
    Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Endothelial cells and cardiomyocytes.
  • 数据库链接：