Mouse complement factor H,CFH ELISA Kit

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.

1. this study shows that complement regulatory protein Factor H is a soluble prion receptor that potentiates peripheral prion pathogenesis PMID: 29070671
2. Factor H and Crry are critical for regulating complement activation at distinct anatomic sites within the kidney. PMID: 27165610
3. VEGF inhibition decreases local CFH and other complement regulators in the eye and kidney through reduced VEGFR2/PKC-alpha/CREB signaling. PMID: 27918307
4. environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice. PMID: 27397653
5. role for serum FH levels in the host response to invasive pneumococcal infections PMID: 26802141
6. absence of plasma CfH conferred susceptibility to glomerulonephritis PMID: 25565310
7. This new understanding of the complicated interactions of CFH in AMD-like pathology provides an improved foundation for the development of targeted therapies for AMD PMID: 25991857
8. data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant. PMID: 26030099
9. Cfh and Cfhr2 genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein. PMID: 25684976
10. A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation. PMID: 24664701
11. A2E accumulation altered retinal microglial complement regulation by decreasing complement factor H (and increasing complement factor B expression), favoring increased complement activation and lipofuscin deposition in the outer retina. PMID: 22819137
12. endogenous fH makes a significant contribution to inhibition of the AP in CAIA through binding to sites of immune complex formation and complement activation. PMID: 23436934
13. Properdin deficiency exacerbated renal injury in mice lacking complement factor H. PMID: 23184055
14. nonsense mutations in SCR19 caused glomerulonephritis PMID: 23204401
15. IL-27 regulates complement activation through up-regulation of complement factor H in the retina. PMID: 23029250
16. CFH influences age-related macular degeneration risk by modulating oxidative stress, inflammation, and abnormal angiogenesis PMID: 22875704
17. Although endogenous factor H (fH) limits the development of allergen-induced airway hyperresponsiveness and airway inflammation, the protection afforded by fH is incomplete. PMID: 22174452
18. complement factor H (CFH) is a major malondialdehyde (MDA)-binding protein that can block both the uptake of MDA-modified proteins by macrophages and MDA-induced proinflammatory effects in vivo in mice PMID: 21979047
19. though factor H doesn't fully prevent activation of the complement alternative pathway on ischemic tubules, its interaction with the tubule epithelial cell surface is critical for limiting complement activation and attenuating renal injury after ischemia. PMID: 21544060
20. Complement factor H (CFH) mRNA is produced in CNS-specific cells, and in astrocytes, the CFH promoter is greatly influenced by the c-Jun and c-Fos transcription factors PMID: 21920606
21. Deletion of adrenomedullin gene, but not of complement factor H, increases infarct volume after permanent focal cerebral ischemia in mice. PMID: 20854881
22. Complement factor H deficiency accelerates development of lupus nephritis. PMID: 21148254
23. Loss of complement factor H is associated with choroidal neovascularization. PMID: 20813971
24. There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry or CR2-factor H. PMID: 20962256
25. Chimeric Cfh proteins led to (AMD)age-related macular degeneration-like characteristics in mice. This may represent a good model for studying the role of complement and other components of the immune system in early AMD. PMID: 20538999
26. In the absence of plasma CFH, the accumulated activated complement leads to spontaneous and chronic serum sickness-induced proliferative glomerulonephritis. PMID: 20702729
27. Complement factor H in the serum contributes to complement regulation on the apical surface of renal tubular epithelial cells. PMID: 20675597
28. role for platelet-associated factor H to process immune complexes and limit their accumulation in glomeruli PMID: 15574507
29. mFH and mFH1-5 do act as cofactors for factor I-mediated cleavage of human C3b. PMID: 16023208
30. These data show that plasma Cfh limits complement activation in the circulation and other accessible sites such as the glomerulus, whereas platelet Cfh is responsible for immune complex processing. PMID: 16597679
31. important role for C5 in both spontaneous membranoproliferative glomerulonephritis (MPGN) and experimentally induced nephritis in factor H-deficient mice and provide preliminary evidence that C5 inhibition therapy might be useful in human MPGN type II PMID: 16769899
32. Alternative complement pathway activation during laser-induced choroidal neovascularization in complement-sufficient C57BL/6 mice is due to increased production of key component factor B as well as reduced expression of regulatory protein factor H. PMID: 16849499
33. A significant level of CFH expression is maintained in different ocular tissues during development and aging. PMID: 16936129
34. Mice intranasally infected with Streptococcus pneumoniae preincubated with Complement Factor H (FH) had increased bacteremia and lung invasion, but they had similar levels of nasopharyngeal colonization compared to mice challenged without FH. PMID: 17562771
35. CFH is critically required for the long-term functional health of the retina. PMID: 17921253
36. The data presented here provide significant new insight into the interaction between CspZ (BBH06)and Factor H and suggest that there is a correlation between CspZ production and dissemination. PMID: 19620346
37. Complement receptor 2 with factor H specifically targets and inhibits the alternative pathway of complement in vitro and is effective in collagen antibody-induced arthritis in vivo. PMID: 19828624

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Secreted.

CFH is one of the most abundant complement components in blood where the liver is the major source of CFH protein in vivo. in addition, CFH is secreted by additional cell types including monocytes, fibroblasts, or endothelial cells.

KEGG: mmu:12628

STRING: 10090.ENSMUSP00000107607

UniGene: Mm.8655