Mouse Vascular endothelial cell growth factor receptor 3 (VEGFR-3/Flt-4) ELISA kit

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

1. VEGFR3 has a role in lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms PMID: 29615616
2. Fluid shear stress regulates vascular remodeling via VEGFR-3 activation, independently of its ligand, VEGF-C, in the uterus during pregnancy. PMID: 28849193
3. Genetic depletion experiments revealed that VEGFR2, but not VEGFR3, is indispensable for maintenance of thyroid vascular integrity. Notably, blockade of VEGF-A or VEGFR2 not only abrogated vascular remodeling but also inhibited follicular hypertrophy, which led to the reduction of thyroid weights during goitrogenesis. PMID: 28438786
4. Report the generation of a Vegfr3-CreER (T2) knockin mouse by gene targeting in embryonic stem cells. This mouse expresses the tamoxifen-inducible CreER(T2) recombinase under the endogenous transcriptional control of the Vegfr3 gene without altering its physiological expression or regulation in the lymphatic system. PMID: 26993803
5. Lymphangiogenic growth in the diaphragm was highly dependent on vascular endothelial growth factor receptor (VEGFR)-3 signaling. During diaphragm development, macrophages appeared first in a linearly arranged pattern, followed by ingrowth of lymphatic vessels along these patterned lines. PMID: 27464987
6. CLEC14A acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 signaling in endothelial cells PMID: 27991863
7. VEGFR3 limits VEGFR2 expression and VEGF/VEGFR2 pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability. PMID: 28298294
8. Blockade of FLT4 suppresses metastasis of melanoma cells by impaired lymphatic vessels. PMID: 27507214
9. Vegf-d and its receptor Vegfr-3 were more highly expressed in lungs of hyperoxic, versus normoxic, wild-type mice, indicating that components of the Vegf-d signalling pathway are up-regulated in hyperoxia. PMID: 26924464
10. this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C, podoplanin and integrin pathways plays a key role. PMID: 27066737
11. Tnfsf15, a cytokine produced largely by endothelial cells, facilitates lymphangiogenesis by up-regulating Vegfr3 gene expression in LECs, contributing to the maintenance of the homeostasis of the circulatory system. PMID: 26096340
12. Results showed that the VEGF-C/VEGFR-3 system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus PMID: 25637798
13. Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling PMID: 25643397
14. The VEGF-C/ VEGFR3 pathway is a positive signal that selectively promotes Neural stem cells activation and conversion into progenitor cells in mice. PMID: 25704818
15. Lymphangiogenesis is induced by mycobacterial granulomas via vascular endothelial growth factor receptor-3 and supports systemic T-cell responses against mycobacterial antigen. PMID: 25597700
16. Vascular endothelial growth factor C/VEGFR-3 signaling modifies HS and CCL21 gradients around lymphatics, regulating lymphocyte migration. PMID: 25606800
17. found that VEGFR2 is required independently of VEGFR3 for endothelial DLL4 up-regulation and angiogenic sprouting, and for VEGFR3 functions in angiogenesis PMID: 25561555
18. Leukemic environment is highly enriched with lymphangiogenic stimuli, and that VEGFR-3 inhibition restored NK cell killing function with an increased IFN-gamma level. PMID: 25157650
19. reveal the evolutionary conservation of the lymphatic-like phenotype of the Schlemm's canal (SC), implicate VEGF-C and VEGFR-3 as critical regulators of SC lymphangiogenesis PMID: 25061878
20. the role of short TRF2 as a preferential core promoter regulator. PMID: 25274728
21. VEGF-C/VEGFR3 signaling plays an important role in the resolution of skin inflammation PMID: 24252749
22. key role in preventing infections in macrophages PMID: 24656836
23. VEGFR-3-mediated lymphangiogenesis thus appears to modulate the folliculogenic microenvironment. PMID: 24036251
24. The cornea expresses a novel truncated isoform of this molecule, soluble VEGFR-3, which is critical for corneal alymphaticity and increase corneal transplant survival. PMID: 23476047
25. Data suggest a regulatory role for VEGFR-3 in megakaryopoiesis. PMID: 22797697
26. results establish that VEGFR2 and VEGFR3 are regulated in a highly differential manner by Notch; successful anti-angiogenic targeting of these receptors and their ligands will strongly depend on the status of endothelial Notch signalling PMID: 22426001
27. Suggest that miR-1236 may function as a negative regulator of VEGFR-3 signaling during inflammatory lymphangiogenesis. PMID: 22223733
28. Macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts. PMID: 21909098
29. role of NF-kappaB p50 in regulating the expression of VEGFR-3, Prox1 and lymphatic vessel density in mammary tissue, liver, and lung PMID: 21166921
30. VEGFR3 activation by its cognate lignads (VEGFR-C/D)is only crucial to lymphangiogenesis but not required for angiogensis and blood vascular development by modulating VEGFR-2 mediated signals. PMID: 20697430
31. systemic inhibition of VEGFR-3 increases inflammatory edema formation and inflammatory cell accumulation despite inhibition of lymphangiogenesis PMID: 20837699
32. A VEGF-C-mediated mechanism plays an important role in the expansion of MALT lymphoma and the administration of Flt-4 antibodies had a suppressive effect on tumor growth. PMID: 20586849
33. Cell adhesion to extracellular matrix induces a downstream signaling using the tyrosine kinase receptor VEGFR-3 as scaffold. PMID: 20431062
34. CLP24 is a novel regulator of VEGFR-2 and VEGFR-3 signaling pathways and of normal lymphatic vessel structure PMID: 20439428
35. VEGFR-3 participates in immune cell traffic from peripheral tissues to secondary lymphoid organs by regulating allograft lymphatic vessel CCL21 production PMID: 20231530
36. A cooperative function of the three Ras proteins in normal development, and a novel aspect of VEGFR3 signalling modulated by Ras in lymphangiogenesis. PMID: 20179099
37. interaction between neuropilin-2 and VEGFR3 mediates proper lymphatic vessel sprouting in response to VEGF-C. PMID: 20065093
38. Prox1 synergizes with the p50 of NF-kappaB to control VEGFR-3 expression. PMID: 19901262
39. Data suggest that VEGFR-3-specific signaling can induce new blood vessels, to which macrophages contribute a major role, and signify its potential as an additional therapeutic target to the existing antiangiogenesis strategies. PMID: 19808642
40. result provides new insights into the involvement of vascular endothelial growth factor 3 signals in the maintenance of vascular integrity through modulation of vascular endothelial growth factor 2 signals PMID: 12393458
41. In almost all monocytic-derived cells in conjunctiva. Might function as "trap" or functional "decoy" receptor by binding VEGF-C and VEGF-D growth factors to prevent lymphangiogenesis and angiogenesis into the cornea. PMID: 12614002
42. Data demonstrate the expression of vascular endothelial growth factor receptor-3 and vascular endothelial growth factor-C on corneal dendritic cells, which implicate a potential relationship between lymphangiogenesis and leukocyte trafficking in the eye. PMID: 12819011
43. VEGFR3 signaling is needed for lymph node metastasis in gastric cancer. PMID: 15072591
44. hypoxia-driven vascular development requires the activity of VEGF receptor-3 PMID: 15466359
45. Ang1 has a role in lymphatic vessel endothelial proliferation, Tie2 expression, and VEGFR-3 upregulation PMID: 15746084
46. Blocking anti-VEGFR3 antibody significantly inhibited not only lymph- but also hemangiogenesis in mice with destrin-mutation in normally avascular cornea. PMID: 15855638
47. VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible for suppressing inflammatory corneal angiogenesis PMID: 16849433
48. cooperative signaling of VEGFR-2 and -3 is necessary for lymphatic migration and proliferation, but VEGFR-3 is redundant with VEGFR-2 for LEC organization into functional capillaries PMID: 17210781
49. Spred1 and spred2 are essential for embrhyonic lymphangiogenesis by regulating VEGFR3 signaling. PMID: 17438136
50. VEGFR-3 levels were not changed either in healthy or in diabetic muscle after the exercise training. PMID: 17766486

显示更多

收起更多

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization.

Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily

Expressed in adult lung and liver, and in fetal liver, brain, intestine and placenta.

KEGG: mmu:14257

STRING: 10090.ENSMUSP00000020617

UniGene: Mm.3291