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  4. Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit

Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit

  • 中文名称：
    小鼠清道夫受体富含半胱氨酸1蛋白M130(CD163)酶联免疫试剂盒
  • 货号：
    CSB-EL004882MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        CD163是一种巨噬细胞的受体，在炎症和组织修复中起着重要作用。它主要存在于巨噬细胞和单核细胞表面，并参与炎症的调节、细胞凋亡和自噬等过程。CD163的表达量可以反映细胞的激活状态，因此可以用于评估炎症反应和疾病的严重程度。在多种炎症性疾病中，CD163的表达量升高，包括风湿性关节炎、红斑狼疮和肝炎等。此外，CD163还可以作为一种肿瘤标记物，在肝癌和肺癌等恶性肿瘤的诊断和治疗中具有潜在的临床应用价值。
        j9九游会登录入口首页生物所提供的Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit属于ELISA检测试剂盒，采用双抗夹心法定量检测鼠血清、血浆、组织匀浆样本中的CD163，其灵敏度为0.23 ng/ml，检测范围为0.93 ng/ml-60ng/ml。
     
  • 别名：
    Cd163 ELISA kit; M130Scavenger receptor cysteine-rich type 1 protein M130 ELISA kit; CD antigen CD163) [Cleaved into: Soluble CD163 ELISA kit; sCD163)] ELISA kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.93 ng/ml-60ng/ml
  • 灵敏度：
    0.23 ng/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    CD163是一种单核细胞的受体，可参与调节细胞的炎症和免疫反应。最新研究表明，CD163在多种疾病的发生发展中起重要作用，如肝病、炎症性肠病、肺炎、骨质疏松等。此外，CD163还可能成为肿瘤治疗的新靶点，相关研究正在进行中。
  • 功能：
    Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.; After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
  • 基因功能参考文献：
    1. house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia PMID: 26376364
    2. In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes. PMID: 27354410
    3. During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch signalling necessary for myogenic progenitor cell proliferation. PMID: 26242746
    4. Data indicate an essential substrate motif for ADAM17-mediated CD163 and proTNF-alpha cleavage in macrophages. PMID: 24275664
    5. alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress. PMID: 22807450
    6. Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209. PMID: 21427223
    7. Assignment of the CD163 antigen to mouse chromosome 6 band F2. PMID: 12698011

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  • 亚细胞定位：
    [Soluble CD163]: Secreted.; Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen and mesenteric lymph nodes.
  • 数据库链接：