Mouse Insulin-like growth factor-binding protein 5(IGFBP5) ELISA kit

1. Data demonstrate that dysregulation of miR-143-3p:Igfbp5 interactions in satellite cells with age may be responsible for age-related changes in satellite cell function. PMID: 26762731
2. proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R inhibitors PMID: 26854565
3. Results from mouse models suggest that inhibiting the up-regulation of IGFBP5 expression in peripheral nerves might prevent or slow down diabetic neuropathy disease progression PMID: 26025657
4. IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis. PMID: 24551065
5. indicate that Igf1 was highly expressed in the mesenchyme, Igf2 and Igf1r were expressed in both the midline epithelium and surrounding mesenchyme, and Igfbp5 was highly expressed in the epithelium. PMID: 23584732
6. investigated the effect of IGFBP5 induction on the progression of liver fibrosis caused by chronic cholangiopathy; expression of IGFBP5 in the Abcb4-/- mice reduces inflammation, oxidative stress, ECM deposition and hepatocyte proliferation, thereby reducing liver fibrosis PMID: 22434064
7. c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling PMID: 22252554
8. Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation. PMID: 22117064
9. Decreased Cav-1 expression in fibrotic diseases likely leads to increased deposition of IGFBP-5 in the extracellular matrix. PMID: 20345844
10. Data indicate that retinal astrocytes enhance the proliferation of cone-like retinoblastoma cells by deploying IGFBP5, a factor that also provides trophic support to the tumor cells' non-neoplastic counterparts. PMID: 20508032
11. insulin-like growth factor binding protein 5 is a modulator of tamoxifen resistance in breast cancer PMID: 20354179
12. Igfbp5 appears to be up-regulated by activation of Akt1 in beta cells or fibroblasts. Knockout studies indicate Igfbp5 may be involved in regulation of metabolism (e.g., glucose intolerance) and growth (i.e., cell size, organ size, and body size). PMID: 19897600
13. the timing of IGF-II expression and regulation of its accessibility by IGFBP-5 may play a role in anterior pituitary differentiation, survival, and/or proliferation PMID: 11944940
14. that over-expression of IGFBP-5 can lead to; impaired mammary development, increased expression of the pro-apoptotic molecule caspase-3, increased plasmin generation and decreased expression of pro-survival molecules of the Bcl-2 family PMID: 12223411
15. IGFBP-5 protein was greatly increased during days 1-3 of mammary gland involution, when levels of apoptosis are dramatically elevated to remodel the gland after lactation PMID: 12538768
16. Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I PMID: 12626499
17. IGFBP-5 is a potent growth inhibitor and proapoptotic agent in human breast cancer cells via modulation of cell cycle regulation and apoptotic mediators PMID: 12777377
18. two of the six serum insulin-like growth factor binding protein-5 quantitative trait loci also showed significant association with total body bone mineral density phenotype PMID: 12865330
19. By depressing association of IGFs with soluble IGFBPs, Zn(2+) is shown to repartition either [(125)I]-IGF-I or [(125)I]-IGF-II from soluble IGFBP-5 onto cell surface IGF receptors at physiological doses depressing IGF binding to IGFBP-5 and IGF-2R PMID: 14566968
20. IGFBP-5 acts in myogenesis on IGF-dependent inhibition of differentiation and IGF-independent cell survival. PMID: 15075235
21. IGFBP-5 has a significant influence on BMD acquisition and maintenance that is dependent on gender and age PMID: 15550514
22. Femurs from TG mice overexpressing Igbf5 have modest alterations in mineral and matrix distribution. PMID: 15570402
23. Ectopic expression of Igfbp5 resulted in the appearance of remarkable curvatures and thinning of hair shafts, two hallmarks of hair bends. Both effects and the natural bending process are under negative control of IGF signalling. PMID: 16024235
24. Data provide support for the hypothesis of dual regulation of IGFBP-5 expression during differentiation and apoptosis in three dimensional cultures of mouse primary epithelial cells. PMID: 16419030
25. IGFBP5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparin PMID: 16505491
26. Data show that prolactin is a potent inhibitor, both of cell death, an effect which is suppressed by insulin-like growth factor-binding protein 5 (IGFBP-5), and of matrix metalloproteinase expression, which is independent of the actions of IGFBP-5. PMID: 16720715
27. Both IGF-I and IGFBP-5 mRNA are the main components of the IGF-I system that are markedly regulated during the osteoblast differentiation of NIH3T3. PMID: 17001448
28. IGFBP-5, although not essential for normal growth, is required for normal mammary gland involution and can regulate mammary gland morphogenesis in response to hormone stimulation PMID: 17255210
29. Insulin-like growth factor-binding protein-5 enters vesicular structures but not the nucleus PMID: 17892529
30. IGFBP5 is a potential regulator of craniofacial skeletogenesis PMID: 18196601
31. Results show that IGFBP-5 interferes with IGF action in osteoblasts and provides a framework for discerning mechanisms of collaboration between signal transduction pathways activated by BMPs and IGFs in bone. PMID: 18292241
32. IGFBP-5 binds to fibronectin cell binding domain. PMID: 19236847
33. Even though wild-type IGFBP-5 severely disrupted the IGF axis, we found no evidence for interaction of mutant IGFBP-5 with the IGF system. PMID: 19332648
34. Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells. PMID: 11606061

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KEGG: mmu:16011

STRING: 10090.ENSMUSP00000027377

UniGene: Mm.405761