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  4. Mouse Hepatocyte Growth Factor Receptor(C-MET/HGFR)ELISA Kit

Mouse Hepatocyte Growth Factor Receptor(C-MET/HGFR)ELISA Kit

  • 中文名称：
    小鼠肝细胞生长因子受体(c-MET/HGFR)酶联免疫试剂盒
  • 货号：
    CSB-E13492m
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    The mouse hepatocyte growth factor receptor (HGFR) ELISA kit is suitable for quantitatively determining mouse HGFR in serum, plasma, or tissue homogenates. This assay employs the bi-antibody sandwich technique and enzyme-substrate chromogenic reaction to quantify mouse HGFR levels in the sample. The amount of synthesized colored product is positively related to the analyte of interest in the sample.

    HGFR, also called MET/c-MET, is stimulated upon HGF binding and further activates downstream effector molecules, thus eliciting Grb2-Ras-Raf-Erk/MAPK, Gab1-Shp2-Erk/MAPK, PI3K-AKT, and STAT3 signaling pathway. HGF/c-MET signaling is involved in different processes including normal development, organ regeneration, cell cycle progression, cell proliferation, survival, migration, invasion, and tumorigenesis. Dysregulation of HGF/cMET signaling plays a crucial role in several human cancers, especially in invasion and metastasis.

  • 别名：
    Met ELISA Kit; Hepatocyte growth factor receptor ELISA Kit; HGF receptor ELISA Kit; EC 2.7.10.1 ELISA Kit; HGF/SF receptor ELISA Kit; Proto-oncogene c-Met ELISA Kit; Scatter factor receptor ELISA Kit; SF receptor ELISA Kit; Tyrosine-protein kinase Met ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.078 ng/mL-5 ng/mL
  • 灵敏度：
    0.02 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cancer
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis.; (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells.
  • 相关疾病：
    Activation of Met after rearrangement with the TPR (translocated promoter) locus of chromosome 1 produces an oncogenic protein.
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family
  • 数据库链接：