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  4. Mouse Follistatin-related protein 1(FSTL1) ELISA kit

Mouse Follistatin-related protein 1(FSTL1) ELISA kit

  • 中文名称：
    小鼠卵泡抑素相关蛋白1(FSTL1)酶联免疫试剂盒
  • 货号：
    CSB-EL009025MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Mouse FSTL1 ELISA Kit was designed for the quantitative measurement of Mouse FSTL1 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.18 ng/mL-12 ng/mL and the sensitivity is 0.04 ng/mL .

  • 别名：
    Fstl1 ELISA Kit; Frp ELISA Kit; Fstl ELISA Kit; Tsc36Follistatin-related protein 1 ELISA Kit; Follistatin-like protein 1 ELISA Kit; TGF-beta-inducible protein TSC-36 ELISA Kit
  • 缩写：
    FSTL1
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.18 ng/mL-12 ng/mL
  • 灵敏度：
    0.04 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse FSTL1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %92
    Range %88-95
    1:2Average %90
    Range %87-94
    1:4Average %95
    Range %92-97
    1:8Average %96
    Range %92-99
  • 回收率：
    The recovery of mouse FSTL1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-98
    EDTA plasma (n=4)9895-100
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    122.765 2.755 2.760 2.659
    61.804 1.776 1.790 1.689
    31.204 1.118 1.161 1.060
    1.50.632 0.622 0.627 0.526
    0.750.354 0.367 0.361 0.260
    0.3750.233 0.245 0.239 0.138
    0.180.164 0.173 0.169 0.068
    00.100 0.102 0.101 　
  • 数据处理：
  • 货期：
    3-5 working days

引用文献

产品评价

靶点详情

  • 功能：
    Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors.
  • 基因功能参考文献：
    1. Haploinsufficiency of Fstl1 in mice contributed to an exacerbated hypoxia-induced Pulmonary hypertension, as demonstrated by increased right ventricular systolic pressure, pulmonary arterial muscularization and right ventricular hypertrophy index PMID: 28361925
    2. this study shows that FSTL-1 modulates IL-17 signaling via IL-17RC regulation in stromal cells PMID: 28377613
    3. FSTL1 may exert its actions through the modulation of Akt signaling. PMID: 28765894
    4. FSTL1 is a secreted osteoclastogenic factor that plays a critical role in osteoclast formation via the NF-kappaB and MAPKs signaling pathways. PMID: 27234130
    5. study indicates a pivotal role for Fstl1 in early stage of lung airway smooth muscle development PMID: 28574994
    6. This study reveals that Fstl1 is essential for the acute repair of the infarcted myocardium and that stimulation of early fibroblast activation is a novel function of Fstl1. PMID: 27234440
    7. Deletion of Fstl1 from the endocardial/endothelial lineage results in deformed mitral valves, which cause regurgitation, heart failure, and early cardiac death. PMID: 28705792
    8. A critical role for the Smad3-c-Jun pathway in the regulation of Fstl1. PMID: 28495857
    9. FSTL1 may induce epithelial mesenchymal transition and airway remodeling by activating autophagy. PMID: 28473327
    10. a new role for FSTL1 in the development of radial glial scaffolds and the neuronal migration of upper-layer projection neurons, is reported. PMID: 26382033
    11. administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation PMID: 26355153
    12. epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1) PMID: 26375005
    13. FSTL1 is a potent regulator of chondrocyte proliferation, differentiation and expression of extracellular matrix molecules. PMID: 24641944
    14. muscle-derived Fstl1 attenuates neointimal formation in response to arterial injury by suppressing smooth muscle cell proliferation through an AMPK-dependent mechanism PMID: 24743592
    15. functions in cardiorenal communication; lack of Fstl1 production by myocytes promotes glomerular and tubulointerstitial damage in the kidney PMID: 25071081
    16. Fstl1 is induced in response to lung injury and promotes the accumulation of myofibroblasts and subsequent fibrosis. These data suggest that Fstl1 may serve as a novel therapeutic target for treatment of progressive lung fibrosis. PMID: 25584011
    17. FSTL1 is elevated in various inflammatory conditions and decreased during the course of treatment. FSTL1 may therefore be a valuable biomarker for such diseases. PMID: 24838142
    18. This study is the first to describe a role for FSTL-1 in the development of Lyme arthritis and anti-Borrelia response. PMID: 24768929
    19. FSTL1 is a potential mediator of inflammation and insulin resistance in obesity. PMID: 24347831
    20. These results suggest that FSTL-1 may act on the NLRP3 inflammasome to promote IL-1beta secretion from monocytes/macrophages. PMID: 24470197
    21. preliminary X-ray crystallographic analysis of recombinant murine Follistatin-like 1 PMID: 23612079
    22. identified FSTL1 as an independent prognostic biomarker in ACS. PMID: 22675198
    23. Fstl1 is essential in maintaining normal ureter development by antagonizing BMP signaling. PMID: 22485132
    24. FRP has the function of evoking innate immune responses as one of the endogenous TLR4 agonists. PMID: 22265692
    25. Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload. PMID: 21987816
    26. Fstl1 KO mice die at birth from respiratory distress and show multiple defects in lung development. Also, skeletal development is affected. PMID: 21826198
    27. FSTL1-dependent activation of Na(+),K(+)-ATPase regulates the threshold of somatic sensation. PMID: 21382556
    28. Fstl1 transgenic mice have improved glucose tolerance were resistant to high-fat diet-induced obesity and hepatic steatosis PMID: 21205933
    29. reduction of Fstl1 expression sensitizes the kidney to acute cisplatin nephrotoxicity, suggesting a role for FSTL1-mediated Il-1beta suppression in protection of the kidney from acute nephrotoxic injury. PMID: 20861081
    30. data suggest downregulation of Fstl1 expression may be an important feature of preadipocyte to adipocyte conversion PMID: 20043993
    31. Studies show that Fstl1 is one of the mesenchymal factors determining oviductal epithelial cell fate. PMID: 20176958
    32. These data indicate that DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. PMID: 20054002
    33. Fstl1 expression is repressed by the microRNA miR-206. PMID: 17030984
    34. In this study, developmental expression pattern of Fstl1 in the mouse was analyzed; Fstl1 is ubiquitously expressed in the early embryo, and that expression becomes regionalized later during development. PMID: 17129766
    35. Fstl1 is a cardiac-secreted factor that functions as an antiapoptotic protein and may play a role in myocardial maintenance and repair in response to harmful stimuli. PMID: 18519848
    36. Fstl1 is a secreted muscle protein or myokine that can function to promote endothelial cell function and stimulates revascularization in response to ischemic insult through its ability to activate Akt-eNOS signaling PMID: 18718903
    37. Endogenous FSTL-1 can be induced by innate immune signals and plays a proinflammatory role in collagen-induced arthritis by enhancing T cell interferon-gamma production. PMID: 19109154

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    During central nervous system development, strongly expressed in the telencephalon, diencephalon, brainstem, limbic system and spinal cord. Widely expressed in all organs.
  • 数据库链接：