Mouse Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) ELISA kit

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R.

1. while Adam17-deficiency suppresses Ang II-induced SMC remodeling in vitro, in vivo Adam17-deficiency provides only a transient protective effect against Ang II-mediated hypertension and end-organ damage. PMID: 27993561
2. Report atheroprotective functions of ADAM17 in myeloid cells but atheroprogressive ADAM17 functions in endothelial cells. PMID: 28004058
3. results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation. PMID: 28004780
4. iRhom2 controls multiple aspects of TACE biology, including stimulated shedding on the cell surface. PMID: 29045841
5. Targeting ADAM17 with a lentiviral vector attenuates endotoxemia in mice. PMID: 28849138
6. Addition of a disintegrin and metallopeptidase domain 17 (ADAM17) to the culture supernatant of stimulated splenocytes decreased Interferon-gamma (IFN-gamma) concentration. PMID: 27573075
7. Overall, iRhom2 binds to TACE throughout its lifecycle, implying that iRhom2 is a primary regulator of stimulated cytokine and growth factor signalling. PMID: 28432785
8. Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR-ligands by differentially activating ADAM17 or ADAM10. PMID: 28703301
9. Fhl2 anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17-mediated release of TNF PMID: 28823868
10. most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR PMID: 27089454
11. ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms PMID: 28877252
12. In a clinically relevant CADASIL mouse model, we show that exogenous ADAM17 or HB-EGF restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3-induced deficits. PMID: 27476853
13. Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment. PMID: 27059842
14. These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 signals during inflammatory processes. PMID: 26561568
15. These results show that TACE is a target of, and is downregulated by, soluble TNF-induced AP-2alpha transcription factor in dendritic cells PMID: 27852742
16. the critical role of the transmembrane domains of ADAM17 and Rhbdf2 in the regulation of the ADAM17 and EGFR, and ADAM17 and TNFalpha signaling pathways, was examined. PMID: 28104813
17. Findings provide evidence that ADAM10, and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH signaling. PMID: 27224017
18. this study shows that the iRhom2/ADAM17 pathway plays an important role in regulating CSF1R expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation PMID: 27601030
19. Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha and TNFR2, thereby preventing overactivation of endogenous TNFR2 signaling in cells of the vasculature. PMID: 28062509
20. Aging and obesity cooperatively reduce caveolin-1 expression and increase vascular endothelial ADAM17 activity and soluble TNF release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients. PMID: 28473444
21. Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase. PMID: 27349870
22. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes. PMID: 27237127
23. These findings suggest that maintaining ADAM17-EGFR epithelial signaling is necessary for the recovery from UC and would be beneficial to therapeutic strategies targeting ADAM17-mediated TNF-a shedding. PMID: 27077118
24. Data show that caveolin 1 (CAV1) is required for transforming growth factor-beta (TGF-beta)-induced reactive oxygen species production, mediated by NADPH oxidase NOX1, that is necessary for a disintegrin and metalloproteinase 17 (ADAM17) activation. PMID: 26815118
25. ADAM12 and ADAM17 are essential molecules for the impairment of barrier function of retinal vasculature under hypoxia. PMID: 26242473
26. 4-Hydroxyisoleucine improved insulin resistant-like state in 3T3-L1 adipocytes by targeting TACE/TIMP3 and the insulin signaling pathway. PMID: 26527864
27. Hypercapnic acidosis blocks stretch-mediated activation of ADAM17. ADAM17 is an important proximal mediator of ventilator-induced lung injury. PMID: 25085885
28. Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease PMID: 26651291
29. Overexpression of ADAM17 increases shed ACE2 and decreases cellular ACE2 levels in pancreatic islets. Whereas ADAM17 has the ability to shed ACE2, ADAM17 does not deplete ACE2 from pancreatic islets in diabetic db/db mice. PMID: 26441236
30. established that endogenous IL-6R of both human and murine origin is shed by ADAM17 in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 PMID: 26359498
31. These data demonstrated that ADAM17 contributed to microglial cell survival, predominantly by EGFR signalling, following spinal cord injury PMID: 25738567
32. These results demonstrate that ADAM17-mediated TNF-alpha signaling from intestinal epithelial cell has a significant role in the development of the proinflammatory state and mucosal atrophy observed in total parenteral nutrition - treated mice. PMID: 26283731
33. Results strongly suggest that TACE contributes to the development of psoriatic lesions through releasing two kinds of psoriasis mediators, TNF-a and EGFR ligands. PMID: 25384035
34. ADAM17 upregulation, within the physiological range, could provide protective effects in ischemic cardiomyopathy. PMID: 26136458
35. ADAM17 was identified as the protease responsible for TNFR2 shedding by CD8(+) T cells, with ADAM17 and TNFR2 required in "cis" for shedding to occur. PMID: 26019295
36. high glucose-induced HIF-1alpha activation and ADAM17 up-regulation. PMID: 26175156
37. Data show that renal cells preferentially secrete klotho to the apical side and suggest that ADAMs are responsible for alpha-cut cleavage. PMID: 26155844
38. Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha) secretion as a result of enhanced activity of TNFalpha-converting enzyme (TACE). PMID: 26183206
39. Data indicate that a disintegrin and metallopeptidase domain 17 (ADAM17) regulates interleukin (IL)-1 signaling via cleavage of IL-1 receptor type 2 (IL-1R2). PMID: 25461404
40. ADAM17 activity is required in retinal angiogenesis, and its blockade resulted in increased TSP1 expression. PMID: 25218057
41. a principal function of iRhoms1/2 during mouse development is to regulate ADAM17-dependent EGFR signaling PMID: 25918388
42. analysis of how ADAM9, 10, and 17 maturation requires processing at a newly identified Proprotein Convertase cleavage site PMID: 25795784
43. Angiotensin II induces ADAM17 expression in the vasculatures through a hypoxia inducible factor 1alpha-dependent transcriptional upregulation, potentially contributing to end-organ damage in the cardiovascular system. PMID: 24871629
44. ADAM17-deficiency models eczematous dermatitis with naturally occurring dysbiosis in mice, similar to that observed in human atopic dermatitis. PMID: 25902485
45. Cav1 is required for TGF-beta-mediated activation of TACE that is responsible for shedding of EGFR ligands and activation of the EGFR pathway. PMID: 25032849
46. ADAM17 induction down-regulates the receptor in an irreversible manner and may serve as a master switch in controlling CXCR2 function. PMID: 25412626
47. ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease. PMID: 24899059
48. All-lymphoid progenitors and other hematopoietic progenitors deficient in ADAM17, have elevated cell surface CSF1R expression. ADAM17(-/-) ALPs, however, fail to yield myeloid cells upon transplantation into irradiated recipients. PMID: 25308957
49. tumor cells TACE-shed MCSF promotes angiogenesis through activation of the NF-kappaB pathway in macrophages and the subsequent release of VEGF. PMID: 24197832
50. findings suggested that TACE overexpression induced macrophage infiltration and subsequent fibrosis in adipose tissues under high fat diet regimen PMID: 25236578

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[Isoform Long]: Cell membrane; Single-pass type I membrane protein.; [Isoform Short]: Secreted.

Ubiquitously expressed. Expressed at highest levels in heart, liver, skeletal muscle, kidney and testes. Expressed at lower levels in brain, spleen and lung.

KEGG: mmu:11491

STRING: 10090.ENSMUSP00000067953

UniGene: Mm.27681