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  4. Mouse Cadherin-3(CDH3) ELISA kit

Mouse Cadherin-3(CDH3) ELISA kit

  • 中文名称：
    小鼠钙黏蛋白3(CDH3)酶联免疫试剂盒
  • 货号：
    CSB-EL005052MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 别名：
    Cdh3; Cdhp; Cadherin-3; Placental cadherin; P-cadherin
  • 缩写：
    CDH3
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    78 pg/mL-5000 pg/mL
  • 灵敏度：
    19.5 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Neuroscience
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能参考文献：
    1. P-Cadherin is not required for maintenance of retinal stem cells in vivo. PMID: 28494434
    2. P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively. PMID: 29338041
    3. P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness. PMID: 22710718
    4. Loss of P-cadherin is associated with melanoma. PMID: 21445019
    5. UVB exposure resulted in the overexpression of the cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and the adhesion molecule P-cadherin. PMID: 20212509
    6. Truncated P-cadherin promotes melanoma cell invasion and migration and therefore has an important role in the progression of malignant melanoma. PMID: 16919267
    7. P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans whereas it is not required for either in mice. PMID: 18199584

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: mmu:12560

    STRING: 10090.ENSMUSP00000079613

    UniGene: Mm.4658