Mouse Bone morphogenetic protein 7,BMP-7 ELISA Kit

Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors.

1. PTEN is a negative regulator of PI3K and BMP-7 increased PTEN expression in vivo and in vitro. These data demonstrate an important mechanism by which BMP-7 orchestrates renal protection through Akt inhibition and highlights Akt inhibitors as anti-fibrotic therapeutics. PMID: 28923783
2. analysis of the mechanisms involved revealed the induction of bone morphogenetic protein-7 (BMP7) expression, a critical regulator of angiogenesis and kidney homeostasis, through a PDE5i-dependent downregulation of miR-22. In conclusion PDE5i slows the progression of Diabetic Nephropathy (DN) in mice, improving hemodynamic parameters and vessel PMID: 28294194
3. Report a novel positive function of mm9_circ_009056 during osteogenesis in regulating BMP7 through miR-22-3p. Furthermore, the expression of mm9_circ_009056 was up-regulated in CGRP-induced cells, whereas miR-22-3p was decreased. PMID: 29709471
4. BMP 7 is a key regulator of Tmem100-mediated cell proliferation in metanephric mesenchymal cells.There is a complicated regulation network among Tmem100, BMP7, and BMPR-II in mouse embryonic kidney-derived cells. PMID: 29247399
5. Overexpression of miR-384-5p significantly decreased BMP7 protein, while depletion of miR-384-5p significantly increased BMP7 protein in renal epithelial cells. PMID: 28526933
6. Bone morphogenetic protein 7 (BMP7) exerts differential effects depending on the concentration; it may expand mesenchymal cells in the stroma where BMP7 concentration is low and may upregulate cadherin-11 promoting condensation around the tip of ureteric buds. PMID: 28867673
7. BMP-7 therefore is an attractive candidate for tackling a multifaceted disease such as diabetes, since it not only reduces body fat, but also strengthens insulin signaling, causing improved glucose uptake and ameliorating peripheral insulin resistance. PMID: 28186649
8. Our studies indicate that BMP7 is an important factor during the process of implantation that contributes to healthy embryonic development. PMID: 28324064
9. The disequilibrium between BMP-7 and TGF-beta signals plays a relevant role in the LV remodelling response to haemodynamic stress in mice subjected to transverse aortic constriction leading to left ventricular hypertrophy/dysfunction. PMID: 27068510
10. the in vivo inter-relationships between Bmp7 and Usag-1, was examined. PMID: 27178071
11. odontoblast beta-catenin signaling may act through regulation of BMP signaling to maintain the integrity of HERS cells PMID: 26208822
12. BMP7 and FGF9 coordinately regulate AP-1 transcription to promote G1-S cell cycle progression and nephron progenitor cells proliferation. PMID: 26634297
13. Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit. PMID: 26010756
14. MiR-22 promotes the development of liver cirrhosis through BMP7 suppression. PMID: 26112332
15. BMP7 induced changes in levels of mRNA and proteins associated with reactive gliosis in retinal astrocytes and Muller glial cells, including glial fibrillary acidic protein, glutamine synthetase, chondroitin sulfate proteoglycans and MMPs. PMID: 25253985
16. We found that the recruited macrophages are polarized to a M2 subtype after renal injury. M2 macrophages released high levels TGFb1 to suppress BMP7 to enhance EMT-induced renal fibrosis. PMID: 25662173
17. Bmp4, Bmp7 and bmpr2 signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo. PMID: 25514175
18. These findings suggest that locally produced BMP7 is prerequisite for postnatal synovial joint homeostasis and may be involved in osteoarthritic changes PMID: 25889639
19. Results demonstrate that disease progression in obstructive uropathy is driven by a cell type specific decrease in the expression of BMP-7 in the mouse. PMID: 25813565
20. we characterize the cis-regulatory organization of a large genomic locus consisting of Tfap2c and Bmp7. We show that this locus is structurally partitioned into two distinct domains by the constitutive action of a discrete transition zone PMID: 25569170
21. cross-talk between Cxcr4-TGF-beta1 and Bmp7 pathways in kidney fibrosis PMID: 25537742
22. BMP-7 polarizes monocytes into M2 macrophages PMID: 24376781
23. results suggest a protective role for BMP-7 in lung allergic inflammation, opposing the pro-fibrotic effects of TGF- beta1 PMID: 24781156
24. interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations PMID: 24816837
25. MiR542-3p suppresses osteogenic differentiation and promotes osteoblast apoptosis by repressing BMP-7. PMID: 24503542
26. BMP7 reverses the aberrant Ras protein activator (Rasal1) methylation associated with kidney fibrosis. PMID: 24480825
27. results indicate that function of Bmp7 to inhibit the differentiation of progenitor cells together with its anti-apoptotic effect on progenitor cells maintains renal progenitor pool in undifferentiated status, and determines the nephron number at birth PMID: 23991197
28. the anti-apoptotic effect of BMP-7 is mainly mediated through receptor BMPR2 and is associated with the activation of PI3K/AKT/GSK3beta pathway PMID: 23494260
29. BMP7 increases mitochondrial activity in mature brown adipocytes via increased fatty acid uptake and oxidation, a process that requires the fatty acid transporters CPT1 and CD36. PMID: 22938691
30. In Muller glia cells, EGF treatment induces the upregulation of Bmp7. PMID: 23362023
31. The findings indicate a requirement for Bmp7 for the coordination of both developmental and mechanistic aspects of palatogenesis. PMID: 23516636
32. Bmp2, Bmp4 and Bmp7 regulate epithelial to mesenchymal transition and have redundant functions in outflow tract myocardium. PMID: 23863481
33. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis PMID: 23455153
34. BMP-7 induced proliferation, and mineralized nodule formation of cementoblasts. PMID: 23390820
35. BMP7 and noggin have different roles in the processes of glial scar formation and neurorestoration in the ischemic brain. PMID: 22297545
36. DEX reduces sepsis-induced AKI by decreasing TNF-alpha and MCP-1 and increasing BMP-7, which is associated with decreasing HDAC2 and HDAC5, as well as increasing acetyl histone H3. PMID: 22933299
37. results underscore the importance of BMP7 in regulating both food intake and energy expenditure, and suggest new therapeutic approaches for obesity and its comorbidities PMID: 22331196
38. Cloacal partitioning is driven by Bmp7 signaling in the cloacal endoderm. PMID: 22253716
39. BMP7 is able to induce differentiation and mineral nodule formation and increase expression and proteome profile of molecules such as BMP1, TGFb and PCPE1 which are responsible for extracellular matrix formation. PMID: 22093042
40. The augmented autocrine BMP7 signaling leads to increases in the anchorage-independent cell growth, migration and metastatic potential in our bone marrow metastatic breast cancer model. PMID: 22274590
41. Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord. PMID: 22159578
42. BMP-7 enhanced renal recovery following the correction of prolonged obstructions that typically lead to irreversible renal injury. PMID: 21880836
43. transfected BMP-7 enhances both in vitro and in vivo osteogenesis PMID: 21506685
44. an unexpected inhibitory role of BMP7 during the onset of ureteric bud outgrowth PMID: 21552539
45. these results indicate that Bmp7 is indirectly required for corpus callosum formation by controlling the timely differentiation of its guidepost cells PMID: 21485009
46. BMP7 expression is induced in embryonic neurons of the cerebral cortex by activating mitogen-activated protein kinase/extracellular signal-regulated kinase signaling. PMID: 20038543
47. Mineralized tissue markers were strongly regulated by BMP-7 almost 3-fold increase in BSP and OCN transcripts. significant increases in OPN and Runx2 mRNA expressions. BMP-7 treatment stimulated cementoblast-mediated biomineralization in vitro PMID: 20681807
48. when both proteins are expressed in the same cell, sclerostin can antagonize BMP signaling directly by inhibiting BMP7 secretion PMID: 20952383
49. Study conclude that inhibition of Gremlin exerts beneficial effects on the diabetic kidney mainly through maintenance of BMP-7 activity and that Gremlin may serve as a novel therapeutic target in the management of diabetic nephropathy. PMID: 20661431
50. Endogenous neural precursor cells protect the young brain from glioblastoma by releasing bone morphogenetic protein-7, which acts as a paracrine tumour suppressor. PMID: 20513660

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Secreted.

TGF-beta family

KEGG: mmu:12162

STRING: 10090.ENSMUSP00000009143

UniGene: Mm.392150