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  4. Mouse A disintegrin and metalloproteinase with thrombospondin motifs 4(ADAMTS4) ELISA kit

Mouse A disintegrin and metalloproteinase with thrombospondin motifs 4(ADAMTS4) ELISA kit

  • 中文名称：
    小鼠金属肽酶含血小板反应蛋白4(ADAMTS4)酶联免疫试剂盒
  • 货号：
    CSB-EL001311MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 别名：
    Adamts4A disintegrin and metalloproteinase with thrombospondin motifs 4 ELISA kit; ADAM-TS 4 ELISA kit; ADAM-TS4 ELISA kit; ADAMTS-4 ELISA kit; EC 3.4.24.82 ELISA kit; Aggrecanase-1 ELISA kit
  • 缩写：
    ADAMTS4
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    3.12 ng/mL-200 ng/ mL
  • 灵敏度：
    0.78 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cell Biology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
  • 基因功能参考文献：
    1. host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth. PMID: 29926003
    2. This study demonstrated that ADAMTS-4 is a new marker of mature oligodendrocytes contributing to the myelination processes and thus to the control of motor capacities. PMID: 28850711
    3. results demonstrate for the first time that ADAMTS4 contributes to diet induced atherosclerosis in ApoE(-/-) mice PMID: 27491335
    4. the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues PMID: 26809777
    5. aggrecan and brevican proteolysis is compensated in Adamts4-/- or Adamts5-/- mice by ADAMTS proteoglycanase family members but a threshold of versican proteolysis is sensitive to the loss of a single ADAMTS proteoglycanase during spinal cord injury PMID: 25101296
    6. ADAMTS4 has roles in melanoma growth and angiogenesis in mice PMID: 23319426
    7. The serine protease tissue plasminogen activator (tPA) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5, were identified as Reelin cleaving enzymes. PMID: 23082219
    8. ADAMTS-4 cleaves Reelin in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 cleaves the N-t site only, while p75 cleaves both sites. PMID: 22819337
    9. Data demonstrate that Adamts1 and Adamts4 play redundant and essential roles in perinatal kidney development. PMID: 21584905
    10. Drastic down-regulation of Adamts4 observed at both E16 and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae. PMID: 20448247
    11. proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue PMID: 20018883
    12. ADAMTS1, ADAMTS4, and ADAMTS5 are expressed in patterns that relate to the expression pattern of versican in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary. PMID: 15659705
    13. ADAMTS-5 is entirely responsible for cleavage in the interglobular domain, but cleavage in the chondroitin sulfate-rich region may be driven by ADAMTS-4 PMID: 17255106
    14. comparison of aggrecan loss with aggrecan processing in mice with single and double deletions of ADAMTS-4 and -5 activity (Deltacat) PMID: 17938173
    15. Deletion of ADAMTS-4/5 provided significant protection against proteoglycan degradation ex vivo and decreased the severity of murine osteoarthritis PMID: 17968948

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 数据库链接：