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  4. Human mucosae associated epithelia chemokine,MEC ELISA Kit

Human mucosae associated epithelia chemokine,MEC ELISA Kit

  • 中文名称：
    人粘膜相关上皮趋化因子(MEC/CCL28)酶联免疫试剂盒
  • 货号：
    CSB-E07310h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human CCL28 ELISA Kit was designed for the quantitative measurement of Human CCL28 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 78 pg/ml - 5000 pg/ml and the sensitivity is 19.5 pg/ml.

  • 别名：
    C C motif chemokine ligand 28 ELISA Kit; C-C motif chemokine 28 ELISA Kit; CC chemokine CCL28 ELISA Kit; CCK 1 ELISA Kit; CCK1 ELISA Kit; CCK1 protein ELISA Kit; CCL 28 ELISA Kit; CCL28 ELISA Kit; CCL28_HUMAN ELISA Kit; Chemokine (C-C motif) ligand 28 ELISA Kit; chemokine (C-C motif) ligand 28 splice variant chi ELISA Kit; MEC ELISA Kit; Mucosae associated epithelial chemokine ELISA Kit; Mucosae-associated epithelial chemokine ELISA Kit; Protein CCK1 ELISA Kit; SCYA28 ELISA Kit; Small inducible cytokine A28 [Precursor] ELISA Kit; small inducible cytokine subfamily A (Cys-Cys); member 28 ELISA Kit; Small-inducible cytokine A28 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    78 pg/ml - 5000 pg/ml
  • 灵敏度：
    19.5 pg/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
  • 基因功能参考文献：
    1. this review discusses the role of CCL28 in innate and adaptive immunity PMID: 28843907
    2. Results show that CCL28 expression was up-regulated under hypoxic condition in lung adenocarcinoma cells. Besides other effects on tumor biology such as immunosuppression, CCL28 could promote angiogenesis in lung adenocarcinoma by directly activating its receptor, CCR3, on microvascular endothelial cells. PMID: 27250766
    3. our results show for the first time that CCL28 contributes to breast cancer progression through the ERK/MAPKmediated anti-apoptotic and metastatic signaling pathway. Antagonists of CCL28 and the MAPK signaling pathway may be used synergistically to treat breast cancer patients. PMID: 28713975
    4. HCC recruits Tregs to promote angiogenesis under hypoxic condition by upregulating CCL28 expression. These findings establish a link between Tregs and hypoxia in HCC growth and may provide a new potential therapeutic target for treating HCC. PMID: 27716621
    5. CCL28 was absent in saliva of primary Sjogren's syndrome patients. This finding did not correlate with salivary IgA levels. PMID: 25567740
    6. disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE PMID: 26642722
    7. CCL28-CCR3 interactions are involved in the homeostatic trafficking of CD4(+) T cells to the upper airways. PMID: 24917456
    8. High CCL28 gene methylation is associated with gastric tumor aggressiveness. PMID: 25740824
    9. CCL28 is a potent growth-promoting factor with the ability to support the in vitro and in vivo functional properties of cultured human hematopoietic cells. PMID: 23509159
    10. These results indicate a role for IL-17A in the human lung by enhancing the expression of CCL28 and hence driving the recruitment of IgE-secreting B cells. PMID: 21447959
    11. tumour hypoxia promotes the recruitment of regulatory T (T(reg)) cells through induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis PMID: 21753853
    12. CCL28 may play dual roles in mucosal immunity as a chemoattractant for cells expressing CCR10 and/or CCR3 such as plasma cells and also as a broad-spectrum antimicrobial protein secreted into low-salt body fluids. PMID: 12538707
    13. CCR10 and its mucosal epithelial ligand CCL28 have roles in the migration of circulating IgA plasmablasts PMID: 12671049
    14. CCL28 produced by keratinocytes is mediated by different signal pathways from CCL27, and both CCL27 and CCL28 are involved in the pathogenesis of inflammatory skin diseases. PMID: 16433680
    15. CCL28 is one link between microbial insult and the exacerbation of pathologies such as asthma, through an NFkappaB-dependent mechanism PMID: 16581045
    16. Expression of CCL28 by epithelial cells from chronically inflamed liver in response to microbial products or interleukin-1 provides a signal to localize CCR10-expressing regulatory T cells at mucosal surfaces. PMID: 16785557
    17. CCL28 mediates mucosal immunity in HIV exposure and infection PMID: 17912348
    18. These studies are the first to show increased CCL28 production during gastrointestinal infection in humans and provide an explanation for the large influx of IgA-secreting cells to the gastric mucosa in H. pylori-infected individuals. PMID: 18426876
    19. There was a robust migration of specific IgA- and IgM-antibody-secreting cells induced by Salmonella vaccination toward the mucosal chemokines CCL25 and CCL28 PMID: 19003934
    20. data reinforce concept that CCL28 may contribute to the pathogenesis of atopic dermatitis probably through selective migration & infiltration of effector/memory T-helper-2 cells in the skin; CCL28 may represent a prognostic marker for disease severity PMID: 19659860

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leu
  • 数据库链接：

    HGNC: 17700

    OMIM: 605240

    KEGG: hsa:56477

    STRING: 9606.ENSP00000354416

    UniGene: Hs.656904