Human cartilage oligomeric protein,COMP ELISA Kit

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

1. Adolescent idiopathic scoliosis patients had significantly high COMP promoter methylation and low gene expression. Positive and high COMP promoter methylation was correlated with young age and high Cobb angle of main curve PMID: 28951969
2. Our findings indicated that hepatic stellate cells-derived COMP collaborated with CD36 and subsequently played an essential role in MEK/ERK and PI3K/AKT-mediated hepatocellular carcinoma (HCC) progression. COMP might act as a promising target for the diagnosis and treatment of aggressive HCC. PMID: 30231922
3. These findings suggest that Zalpha domain of human ADAR1 binding with the GAC hairpin stem in COMP can lead to a non-genetic, RNA editing-mediated substitution in COMP that may then play a crucial role in the development of pseudoachondroplasia. PMID: 28924040
4. Higher serum COMP levels in knee osteoarthritis reflect knee structural damage. PMID: 29164307
5. COMP (and C-reactive protein) serum levels were both associated with the incidence of knee osteoarthritis. PMID: 29351749
6. Data indicate cartilage oligomeric matrix protein (COMP) homozygote missense variant [c.1423G>A; p.(D475N)] in 2 severely affected pseudoachondroplasia individuals. PMID: 28685811
7. The serum COMP is a promising biomarker in rheumatoid arthritis which reflects disease activity and damage to the articular cartilage. PMID: 28889184
8. COMP promoted colon cancer cell proliferation partially through the activation of PI3K/ Akt/ mTOR/ p70S6K pathway. PMID: 29560517
9. The findings suggest that upregulation of ADAMTS-7 and down regulation of COMP are associated with human AA. PMID: 28849199
10. Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement. PMID: 28319091
11. COMP is a novel biomarker in breast cancer, which contributes to the severity of the disease by metabolic switching and increasing invasiveness and tumor cell viability, leading to reduced survival in animal models and human patients. PMID: 27065333
12. The average sCOMP level was highest among the controls and lowest among the infected children. In the juvenile idiopathic arthritis patients, the level of sCOMP was not associated with the level of CRP or with clinical signs of disease activity. PMID: 27385219
13. COMT Val158Met polymorphism may influence responses to dextromethorphan (30 mg/d) by decreasing depressive symptoms in BD patients. PMID: 27930497
14. The serum COMP level has the potential to be used as a biological marker for differentiating between patients with rheumatoid arthritis and healthy individuals. PMID: 27217240
15. The current study expanded the mutation spectrum of the COMP gene, and contributes to the understanding of phenotype/genotype of COMPassociated diseases. PMID: 27432013
16. In the absence of ultrasonographic knee cartilage deformation, the response of serum lubricin and COMP following acute vigorous exercise indicates an increase in joint lubrication and cartilage metabolism, respectively, which appears largely independent of exercise modality. PMID: 27251407
17. Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum. PMID: 27699484
18. Results suggest that serum oligomeric matrix protein and hyaluronic acid (COMP and HA) concentrations can be used to predict early cartilage lesions in the knee. PMID: 26634947
19. Serum COMP levels are predictive of subsequent structural changes and incidence of painful knee osteoarthritis. PMID: 26848781
20. The expression of COMP in circulation reflects the severity of rheumatoid arthritis. PMID: 27455560
21. findings suggest that Cartilage oligomeric matrix protein (COMP) is associated with the stage of liver fibrosis in chronic hepatitis C PMID: 26269256
22. The GG genotype of Med23 gene associate with Cognitive Decline and Dementia. PMID: 25835418
23. determined if structural differences of the TSPs imparted different effects on vascular smooth muscle cell functions critical to the formation of neointimal hyperplasia PMID: 26168731
24. COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins. PMID: 25111190
25. Overexpression of COMP inhibits BMP-2-induced osteogenic differentiation and promotes BMP-2-induced chondrogenic differentiation. PMID: 25430711
26. Real-time polymerase chain reaction (RT-PCR) assay presented significantly higher (p<0.01) COMP expression of mesenchymal stem cells cultured with HA/COMP multilayered films. PMID: 25380520
27. Mutations in specific residues and/or regions of the type III repeats of COMP are significantly associated with either Pseudoachondroplasia or multiple epiphyseal dysplasia. PMID: 24595329
28. Serum COMP was not acutely influenced by experimental anterior knee pain during running. PMID: 24907621
29. Novel cartilage oligomeric matrix protein (COMP) neoepitopes identified in synovial fluids from patients with joint diseases using affinity chromatography and mass spectrometry. PMID: 24917676
30. Variants within the cartilage oligomeric matrix protein (COMP) gene are not associated with Achilles tendinopathy PMID: 23875975
31. COMP-C3b complexes are found in the serum of patients with systemic sclerosis PMID: 24330664
32. COMP is up-regulated in idiopathic pulmonary fibrosis. PMID: 24376648
33. COMP-C3b levels were higher in patients with rheumatoid arthritis than in healthy controls and lower in extraarticular rheumatoid arthritis (ExRA) than in rheumatoid arthritis controls. PMID: 24187101
34. Athletes with femoroacetabular impingement had a 24% increase in plasma COMP levels. PMID: 23959964
35. A mutation c.1048_1116del in exon 10, inherited from his father who did not demonstrate any phenotypic feature of PSACH PMID: 24229584
36. Enhanced deposition of COMP is a common feature in fibrotic skin pathologies. PMID: 23507196
37. This study demonstrates that COMP enhances the osteogenic activity of BMP-2, both in-vitro and in-vivo. PMID: 23528838
38. Early increase in serum-COMP is associated with joint damage progression over the first five years in patients with rheumatoid arthritis. PMID: 23915292
39. DNA sequencing analysis of the COMP gene revealed a heterozygous mutation. PMID: 23562786
40. serum levels of COMP in Kashin-Beck disease were increased compared with healthy controls, but lower than in osteoarthritis patients, and the increase was not correlated with disease severity. PMID: 22068351
41. COMPcc may be involved in signalling functions in which hydrophilic ligands are involved PMID: 23133613
42. The proximal 3 Kb of the human cartilage oligomeric matrix protein promoter is sufficient to mediate a mechanoresponse in human articular chondrocytes and stem cells. PMID: 22764748
43. Data indicate that cartilage oligomeric matrix protein (COMP-C3b levels are elevated in several rheumatologic diseases and correlate with inflammatory measures in rheumatoid arthritis (RA). PMID: 22264230
44. Serum COMP was not related to endothelial function in patients with rheumatoid arthritis , or to other cardiovascular risk factors studied. PMID: 22660798
45. Detection of cartilage oligomeric matrix protein using a quartz crystal microbalance. PMID: 22163547
46. Serum COMP early in disease is a predictor of mortality in systemic sclerosis patients. PMID: 22253028
47. Type III repeat region COMP mutations have been identified in 27 of the 28 patients with pseudoachondroplasia. COMP mutations have been identified in 37 patients with multiple epiphyseal dysplasia, which were distributed between nine exons. PMID: 21922596
48. Study conclude that TGF-beta1 binds to COMP and that TGF-beta1 bound to COMP has enhanced bioactivity. PMID: 21940632
49. Radiographic findings in patients with COMP and MATN3 mutations showed marked abnormalities in hip and knee joints. PMID: 21965141
50. COMP facilitates keloid formation by accelerating collagen deposition, thus providing a new therapeutic target. PMID: 21872564

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Multiple epiphyseal dysplasia 1 (EDM1); Pseudoachondroplasia (PSACH)

Secreted, extracellular space, extracellular matrix.

Thrombospondin family

Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.

HGNC: 2227

OMIM: 132400

KEGG: hsa:1311

STRING: 9606.ENSP00000222271

UniGene: Hs.1584