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中文名称:人转化生长因子β1(TGF-β1)酶联免疫试剂盒
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货号:CSB-E04725h
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规格:96T/48T
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价格:¥3200/¥2500
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其他:
产品详情
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产品描述:TGF-β1(Transforming Growth Factor-beta 1)是一种重要的细胞因子,可以影响多种生物学过程,如细胞增殖、分化、凋亡和细胞外基质合成等。它的含量通常在生长、发育、组织修复和免疫应答过程中显著增加。TGF-β1的异常表达和活性在多种疾病的发生和发展中发挥了重要作用,如癌症、肺纤维化、风湿性关节炎等。j9九游会登录入口首页生物所提供的Human Transforming Growth factor β1,TGF-β1 ELISA kit属于ELISA检测试剂盒,采用双抗夹心法定量检测人血清、血浆、细胞培养上清样本中的TGFB1,其灵敏度为0.747 ng/mL,检测范围为0.78 ng/mL-50 ng/mL。
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别名:Cartilage-inducing factor ELISA Kit; CED ELISA Kit; Differentiation inhibiting factor ELISA Kit; DPD1 ELISA Kit; LAP ELISA Kit; Latency-associated peptide ELISA Kit; Prepro transforming growth factor beta 1 ELISA Kit; TGF beta 1 ELISA Kit; TGF beta ELISA Kit; TGF beta 1 protein ELISA Kit; TGF-beta 1 protein ELISA Kit; TGF-beta-1 ELISA Kit; TGF-beta-5 ELISA Kit; TGF-beta1 ELISA Kit; TGFB ELISA Kit; Tgfb-1 ELISA Kit; tgfb1 ELISA Kit; TGFB1_HUMAN ELISA Kit; TGFbeta ELISA Kit; TGFbeta1 ELISA Kit; Transforming Growth Factor b1 ELISA Kit; Transforming Growth Factor beta 1 ELISA Kit; Transforming growth factor beta 1a ELISA Kit; transforming growth factor beta-1 ELISA Kit; transforming growth factor, beta 1 ELISA Kit
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缩写:
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Uniprot No.:
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种属:Homo sapiens (Human)
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样本类型:serum, plasma, cell culture supernates
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检测范围:0.78 ng/mL-50 ng/mL
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灵敏度:0.747 ng/mL
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Signal Transduction
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测定原理:quantitative
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测定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays):CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
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线性度:
To assess the linearity of the assay, samples were spiked with high concentrations of human TGF-β1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
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标准曲线:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
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数据处理:
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货期:3-5 working days
引用文献
- Native characterization and QC profiling of human amniotic mesenchymal stromal cell vesicular fractions for secretome-based therapy V Marassi,Talanta,2024
- Serum proteomics identify CSF1R as a novel biomarker for postoperative recurrence in chronic rhinosinusitis with nasal polyps Y Niu,World Allergy Organization journal,2024
- Phonotyping Transition of Infiltrating Hepatic Monocytes to Fibroblasts In CHC Patient's Induced Liver Cirrhosis NE El,/,/
- Levocetrizine attenuates cyclophosphamide-induced lung injury through inhibition of TNF-α, IL-1β, TGF-β and MMP-9 DH El-Kashef,BMC pharmacology & toxicology,2023
- Silica-exposed macrophages-secreted exosomal miR125a-5p induces Th1/Th2 and Treg/Th17 cell imbalance and promotes fibroblast transdifferentiation M Ding,Ecotoxicology and environmental safety,2023
- Serum exosome-derived miR-146a-3p promotes macrophage M2 polarization in allergic rhinitis by targeting VAV3 via PI3K/AKT/mTOR pathway C Xia,International immunopharmacology,2023
- Notch Signaling Regulates the Function and Phenotype of Dendritic Cells in Helicobacter pylori Infection Q Liu,Microorganisms,2023
- Quality Control, Anti-Hyperglycemic, and Anti-Inflammatory Assessment of Colvillea racemosa Leaves Using In Vitro, In Vivo Investigations and Its Correlation with the Phytoconstituents Identified via LC-QTOF-MS and MS/MS MS Abd El Hafeez,Plants-Basel,2023
- Tensile Stress‐Activated and Exosome‐Transferred YAP/TAZ‐Notch Circuit Specifies Type H Endothelial Cell for Segmental Bone Regeneration X Wu,Advanced science,2024
- STA9090 as a Potential Therapeutic Agent for Liver Fibrosis by Modulating the HSP90/TβRII/Proteasome Interplay: Novel Insights from In Vitro and In Vivo Investigations OA Mohammed,Pharmaceuticals,2023
- Alteration of Mesenchymal Stem Cells Isolated from Glioblastoma Multiforme under the Influence of Photodynamic Treatment K Tumangelova-Yuzeir,Current issues in molecular biology,2023
- Differences in injectable platelet-rich fibrin fraction of peripheral blood on the release of TGF-β1 and PDGF-AB S Suryono,Majalah Kedokteran Gigi Indonesia,2023
- VALUTAZIONE DELL'UTILIZZO DEL LISATO PIASTRINICO (LP) IN MEDICINA RIGENERATIVA VETERINARIA EDE DELLA LOMBARDIA,/,2023
- Interleukin-35 dampens T helper 22 phenotype shift in CD4+ CD25+ CD127dim/-regulatory T cells in primary biliary cholangitis C Qiu,International immunopharmacology,2023
- Cytokines Profile and Lung Function in Children with Obesity and Asthma: A Case Control Study L Maffeis,Children,2022
- Serum Lipopolysaccharide Is Associated with the Recurrence of Atrial Fibrillation after Radiofrequency Ablation by Increasing Systemic Inflammation and Atrial Fibrosis M Wang,Oxidative Medicine and Cellular Longevity,2022
- ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome L Zhang,Stem cell research & therapy,2022
- Contribution of Adiponectin/Carnitine Palmityl Transferase 1A-Mediated Fatty Acid Metabolism during the Development of Idiopathic Pulmonary Fibrosis W Wu,Oxidative Medicine and Cellular Longevity,2022
- Assessing the Potential Value and Mechanism of Kaji-Ichigoside F1 on Arsenite-Induced Skin Cell Senescence Q Zeng,Oxidative Medicine and Cellular Longevity,2022
- Reactive oxygen species-evoked endoplasmic reticulum stress mediates 1-nitropyrene-induced epithelial-mesenchymal transition and pulmonary fibrosis L Fu,Environmental pollution,2021
- In-vivo wound healing activity of a novel composite sponge loaded with mucilage and lipoidal matter of Hibiscus species Reham I. Amer,Biomedicine & Pharmacotherapy,2021
- Carica papaya leaf extract inhibits prostatitis-associated prostatic hyperplasia via the TRAF6/TAK1/MEK/NF-κB pathway Jae-Yun Ju,Biomedicine & Pharmacotherapy,2021
- Measurement of Interleukin 17a and Transforming Growth Factor-?1 and Its Relation to Disease Activity in Systemic Lupus Erythematosus Patients MT Alaanzy,Indian Journal of Forensic Medicine & Toxicology,2020
- Chitosan protects liver against ischemia-reperfusion injury via regulating Bcl-2/Bax, TNF-α and TGF-β expression H Saleh,International Journal of Biological Macromolecules,2020
- Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway F Ma,Theranostics,2020
- Comparison of whole egg v. egg white ingestion during 12 weeks of resistance training on skeletal muscle regulatory markers in resistance-trained men R Bagheri,Br J Nutr,2020
- Angiopoietin-like protein 2 as a novel marker for patients with primary Sjogren\\\'s syndrome-related interstitial lung disease. L Shi,Clin. Exp. Med,2020
- Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes mellitus: a cross-sectional cohort study H Ren,Frontiers of Medicine,2020
- Complete Human Penile Scaffold for Composite Tissue Engineering: Organ Decellularization and Characterization Yu Tan, et al,Scientific Reports,2019
- miR-191 is involved in renal dysfunction in arsenic-exposed populations by regulating inflammatory response caused by arsenic from burning arsenic-contaminated coal Y Xu, et al,Human & Experimental Toxicology,2019
- Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer Xie HJ, et al,Artificial Cells Nanomedicine and Biotechnology,2019
- Macrophages induce natural killer cell dysfunction via KIR2DL1 during Echinococcus multilocularis infection Bayindala, et al,Tropical Journal of Pharmaceutical Research,2019
- Thymic stromal lymphopoietin induced early stage of epithelial-mesenchymal transition in human bronchial epithelial cells through upregulation of transforming growth factor beta 1 Cai LM, et al,Experimental Lung Research,2019
- The effect of cartilage extracellular matrix particle size on the chondrogenic differentiation of bone marrow mesenchymal stem cells Zhai C, et al,Regenerative Medicine,2019
- In vitro response of human ovarian cancer cells to dietary bioflavonoid isoquercitrin Michalcova K, et al,Journal of Environmental Science and Health Part B-Pesticides Food Contaminants and Agricultural Wastes,2019
- A comparative study of the effects of concentrated growth factors in two different forms on osteogenesis in vitro Wang L,Molecular Medicine Reports,2019
- Shikonin Controls the Differentiation of CD4+CD25+ Regulatory T Cells by Inhibiting AKT/mTOR Pathway Zhang X,Inflammation,2019
- Hypoxic preconditioning enhances cell hypoxia tolerance and correlated lncRNA and mRNA analysis DongWang.et al,Life Sciences,2018
- A New Treatment Modality for Rheumatoid Arthritis: Combined Photothermal and Photodynamic Therapy Using Cu7.2S4 Nanoparticles Yao Lu.et al,ADV HEALTHC MATER,2018
- High-temperature Requirement Protein A1 Regulates Odontoblastic Differentiation of Dental Pulp Cells via the Transforming Growth Factor Beta 1/Smad Signaling Pathway Xian-Yu Li.et al,J Endod,2018
- Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface Li N.et al,Braz J Med Biol Res,2017
- Extensively disturbance of regulatory T cells - Th17 cells balance in stage II pulmonary sarcoidosis Jingjing Ding.et al,Int J Med Sci,2017
- IL-10?Producing Infliximab-Specific T Cells Regulate the Antidrug T Cell Response in Exposed Patients Vultaggio A.et al,J Immunol,2017
- An immunosuppressive function of interleukin-35 in chronic hepatitis C virus infection Liu S.et al,Int Immunopharmacol.,2017
- Differing Expression of Cytokines and Tumor Markers in Combined Pulmonary Fibrosis and Emphysema compared to Emphysema and Pulmonary Fibrosis Xu, Ling.et al,COPD: Journal of Chronic Obstructive Pulmonary Disease ,2017
- Effects of ranibizumab on TGF-β1 and TGF-β2 production by human Tenon's fibroblasts: An in vitro study Noh SM.et al,Mol Vis.,2015
- Effects of ranibizumab on TGF-尾1 and TGF-尾2 production by human Tenon?? fibroblasts: An in vitro study Noh SM. et al,Mol Vis,2015
- EFFECTS OF L-CARNITINE SUPPLEMENTATION ON INFLAMMATORY FACTORS AND MALONDIALDEHYDE IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS (NASH). Amiri-Moghadam, Shirin.et al,Current Topics in Nutraceutical Research,2015
- The S protein of hepatitis B virus promotes collagen type I expression in hepatic stellate cells by virtue of hepatocytes Xudong Liu et al,Biomedical Reports,2014
- TGF-ß1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence Sun C et al,Plos pathogens,2012
- MFG-E8, a clearance glycoprotein of apoptotic cells, as a new marker of disease severity in chronic obstructive pulmonary disease Zhang S. et al,Braz J Med Biol Res,2015
- Enhanced NK cell adoptive antitumor effects against breast cancer in vitro via blockade of the transforming growth factor-ß signaling pathway Zhao Y. et al,Onco Targets Ther,2015
- Response of layer and broiler strain chickens to parenteral administration of a live Salmonella Typhimurium vaccine Groves PJ. et al,Poult Sci. ,2015
- Platelet-rich plasma (PRP): an adjuvant to hasten hamstring muscle recovery. A randomized controlled trial protocol (ISCRTN66528592) /,BMC Musculoskeletal Disorders,2012
- Bedside-Friendly Prediction for Presence of Post-Myocardial lnfarction Systolic Dysfunction Using Multimarker Panel: Integrating Salivary Diagnostics into Assareh A et al,Korean Circ J,2013
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靶点详情
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最新研究进展:TGFB1是一种细胞因子,可影响细胞增殖、分化、凋亡和胚胎发育等生物学过程。最近的研究表明,TGFB1在心脏疾病和纤维化方面发挥着重要作用。例如,一项研究发现,通过阻断TGFB1信号通路可以减轻心肌缺血再灌注损伤引起的心肌纤维化。此外,TGFB1在肿瘤发生和发展中也发挥着重要作用,其过度表达与癌细胞增殖、转移和免疫逃逸相关。
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功能:Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.; Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia (Probable). Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.; Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal. While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types.
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基因功能参考文献:
- CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells. PMID: 29985912
- blocking TGF-b signaling with the TGF-b receptor inhibitor SB431542 counteracted the effect of platelets on KLF6 expression and proliferation of HCC cells. Based on these findings, we conclude that platelet releasates, especially TGF-b, promote the proliferation of SMMC.7721 and HepG2 cells by decreasing expression of KLF6 PMID: 28638139
- Stimulation of cancer cells with TGFbeta1 weakened the ability of glioblastoma cells to attract hematopoietic stem cells (HSCs) and exchange a fluorescent tag. This process stimulated cancer cell proliferation, which is an indication of the ability of HSCs to 'switch' the proliferation and invasion processes in glioblastoma cells. PMID: 30226551
- Long non-coding RNA 886 is induced by TGF-beta and suppresses the microRNA pathway in ovarian cancer. PMID: 29563500
- these findings demonstrate that JunB and CBP-mediated histone hyperacetylation are responsible for TGF-beta1 induced ITGB6 transcription in oral squamous cell carcinoma (OSCC) cells, suggesting that epigenetic mechanisms are responsible for the active transcription expression of ITGB6 induced by TGF-beta1 in OSCC cells. PMID: 29274289
- TGF-beta induces MIR100HG lncRNA, encoding miR-100, let-7a and miR-125b that control pancreatic ductal adenocarcinoma tumorigenesis. Pro-tumorigenic miR-100 and miR-125b increase and anti-tumorigenic let-7a is unchanged, as TGF-beta also induces LIN28B. The induction of LIN28B results in the up-regulation of miR-100 and miR-125b, with let-7a unchanged despite being part of the same MIR100HG primary transcript. PMID: 29748571
- expression increased in cervical intraepithelial neoplasia (CIN) I and CIN II and decreased in CIN III and cancer PMID: 30059872
- Studies indicate that transforming growth factor-beta (TGF-beta) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction [Review]. PMID: 30150520
- A possible mechanism has been proposed of the TGF-beta-VEGF-C pathway in which TGF-beta promotes VEGF-C production in tubular epithelial cells, macrophages, and mesothelial cells, leading to lymphangiogenesis in renal and peritoneal fibrosis. (Review) PMID: 30142879
- we observed that human TGF-beta1 could up-regulate the expression of CD147 in response to arecoline and that inhibition of TGF-beta1 could down-regulate this expression. The data presented here suggest that TGF-beta1 may promote OSF progression via CD147. PMID: 29457855
- TGF-beta activity is elevated in human heterotopic ossification patients. PMID: 29416028
- FZD8 silencing reduces prostate cancer cell migration, invasion, three-dimensional (3D) organotypic cell growth, expression of EMT-related genes, and TGF-beta/Smad-dependent signaling PMID: 29717114
- Data suggest that resolvin D1/RVDR1 signaling (1) promotes epithelial wound repair, (2) inhibits TGFB-induced epithelial-mesenchymal transition in type II alveolar cells, (3) inhibits fibroproliferation and apoptosis, (4) reduces effects of TGFB on primary lung fibroblast collagen production, and (5) inhibits myofibroblast differentiation. (RVDR1 = resolvin D1 receptor) PMID: 29083412
- this paper shows that TGF-beta1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis PMID: 28832026
- on the basis of present results, TGFB1 (-509C/T) can be considered as a predisposing factor of idiopathic scoliosis (IS)with a moderate individual effect on deformity development in Bulgarian patients; results may suggest that there is an association of the TGFB1 (-509C/T) polymorphism with susceptibility to IS in the female population with sporadic or familial IS and early or late onset IS PMID: 30079294
- Treatment of GLS1-deficient myofibroblasts with exogenous glutamate or alpha-KG restored TGF-beta1-induced expression of profibrotic markers in GLS1-deficient myofibroblasts. Together, these data demonstrate that glutaminolysis is a critical component of myofibroblast metabolic reprogramming that regulates myofibroblast differentiation. PMID: 29222329
- High TGFB1 expression is associated with cardiac fibrosis. PMID: 30340644
- Our findings provide a novel insight of endometriosis that the hypoxic microenvironment stimulates endometrial stromal cells to produce excessive TGF-beta1 and activates the TGF-beta1/Smad signaling pathway, thus enhancing integrin expression and the adhesion ability of endometrial stromal cells. PMID: 29438550
- Prodomain-growth factor swapping in the structure of pro-TGF-beta1. PMID: 29109152
- Inductive effect of TGF-beta on podoplanin seems to be limited. PMID: 29577431
- RHCG was down-regulated in cervical cancers compared to that in normal cervical tissues, and further decreased in cervical cancer cell lines. Functionally, RHCG overexpression reduced cervical cancer cell proliferation and migration, as evidenced by the decreased transforming growth factor (TGF)-beta1, matrix metalloproteinase (MMP)-2 and MMP-9 expressions in cancer cells. PMID: 29852177
- Following Schistosoma exposure, TSP-1 levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 inhibition or knockout bone marrow prevents TGF-beta activation and protects against pulmonary hypertension development. PMID: 28555642
- TGFbeta1 reduced complex IV protein MTCO1 abundance in both myoblasts and myotubes. PMID: 29335583
- TGF-beta1 expression is regulated by PlncRNA-1 in breast cancer. PMID: 29626321
- Elevated AhR expression may be involved in the progression of tissue remodeling in chronic rhinosinusitis without nasal polyp without allergic rhinitis similar to TGF-beta1 expression PMID: 29183012
- Overall, these findings suggest a more dominant role for SMAD3 and SMAD4 than SMAD2 in TGFbeta-induced chondrogenesis of human bone marrow-derived mesenchymal stem cells. PMID: 28240243
- High TGF beta expression is associated with Chronic Periodontitis. PMID: 30051674
- Fewer TIMP-2, Hsp70 and TGF-beta1 immunoreactive cells in younger individuals and increased expression of Hsp70 in elderly individuals demonstrated the influence of aging in lung remodeling PMID: 29325453
- Data show that TGFbeta1-mediated EMT involves CD44 splice isoform switching in ovarian cancer cells. PMID: 29130517
- Gene silencing experiments of MLL4 and the subunits PA1 and PTIP confirm TGF-beta-specific genes to be regulated by the MLL4 complex, which links TGF-beta signaling to transcription regulation by the MLL4 methyltransferase complex. PMID: 28976802
- TGF-beta1 is significantly overexpressed in tumor tissue samples of clear cell Renal cell carcinoma patients. TGF-beta1 up-regulation could be responsible for the high levels of NNMT observed in clear cell Renal cell carcinoma tissues. PMID: 29974846
- TGF-beta role in the promotion of DNA damage and genomic instability in cancer cells. PMID: 29074538
- TGFbeta1 induced the expression alphaSMA, Col1 and fibronectin, and stimulated fibroblastmediated contraction of collagen gel. PMID: 30015862
- miR-203 expression also inhibited primary tumor growth in ovaries and metastatic tumors in multiple peritoneal organs including liver and spleen. miR-203 inhibits ovarian tumor metastasis by targeting BIRC5/survivin and attenuating the TGFbeta pathway. PMID: 30241553
- NK cells from liver cirrhosis (LC) patients could enter hepatic stellate to form emperipolesis (a cell-in-cell structure) and become apoptotic; anti-TGF-b treatment ameliorated this emperipolesis. PMID: 28291251
- therapeutic activation of ERbeta elicits potent anticancer effects in Triple-negative breast cancer through the induction of a family of secreted proteins known as the cystatins, which function to inhibit canonical TGFbeta signaling and suppress metastatic phenotypes both in vitro and in vivo. PMID: 30257941
- These findings suggest that TGFbeta plays a vital role in triple-negative breast cancer epirubicin-resistance through regulating stemness, Epithelial-Mesenchymal Transition and apoptosis. PMID: 29792857
- TGF-beta release from platelets is necessary for podoplanin-mediated tumor invasion and metastasis in lung cancer. PMID: 28176852
- Treating HepG2 cells with hepatotoxicants resulted in a significant increase in mRNA expression of platelet-derived growth factor BB (PDGF-BB) and transforming growth factor beta (TGFbeta). PMID: 29558627
- In contrast with some reports involving the correlation between polymorphisms of the TGF-beta1 and IL-2 genes and inhibitor development in the world, no statistically significant differences in analysis of the alleles and genotypes for TGF-beta and IL-2 genes were found between the inhibitor and non-inhibitor Iranian patients PMID: 29993342
- The findings of the present study indicated that miR326 inhibited endometrial fibrosis by suppressing the TGFbeta1/Smad3 signaling pathway, suggesting that miR326 may be a prognostic biomarker and therapeutic target for Intrauterine adhesion (IUA). PMID: 29956752
- Characterization of gene expression profiles in hepatitis B-related liver fibrosis patients identified ITGBL1 and its interactions with TGFB1 as key regulators of fibrogenesis. PMID: 28262670
- TGF-beta1 and arginase-1 may play important roles in determining long-term graft survival. PMID: 30074212
- Two polymorphic sites of TGF-beta1 gene were identified: -509C/T and +869T/C. We found that the -509C/T polymorphism was associated with increased asthma risk under the heterozygous mode land the dominant model. Subgroup analyses by age suggested that -509C/T variant was associated with childhood asthma. PMID: 29958018
- proinflammatory cytokines suppressed the TGFbetamediated expression of NGF in PDLderived fibroblasts through the inactivation of TGFbetainduced Smad2/3 and p38 MAPK signaling. PMID: 29901090
- FXR agonist treatment enhanced TGF-beta-induced epithelial mesenchymal transition(EMT) morphologic changes and FXR antagonist inhibited the effect of TGF-beta;. Thus, FXR activation enhances EMT in hepatocellular carcinoma (HCC) and FXR antagonists may be EMT-suppressing drug candidates. PMID: 29958417
- Autosomal Dominant Polycystic Kidney Disease patients with moderately preserved renal function have higher levels of FasL, myostatin and urine TGF-beta1 than controls PMID: 29794429
- No increased risk for developing immune thrombocytopenia (ITP) was associated with any allele/genotype of tumor necrosis factor beta (TNFB) + 252G/A gene polymorphism. PMID: 29020887
- Suppression of TGF-beta1 enhances chemosensitivity of cisplatin-resistant lung cancer cells through the inhibition of drug-resistant proteins PMID: 28918673
- The results of the present study indicated that CD8+ T cells with high TGFbeta1 expression served an important role in LN fibrosis following HIV infection. PMID: 29749506
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相关疾病:Camurati-Engelmann disease (CAEND)
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亚细胞定位:[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix.; [Transforming growth factor beta-1]: Secreted.
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蛋白家族:TGF-beta family
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组织特异性:Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.
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数据库链接:
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