Human Soluble protein-100,S-100 ELISA Kit

Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole.

1. Data suggest that TRPM4 exhibits binding sites for calmodulin (CaM) and S100 calcium-binding protein A1 (S100A1) located in very distal part of TRPM4 N-terminus. (TRPM4 = transient receptor potential cation channel subfamily M member 4) PMID: 29240297
2. Data found that S100A1 was upregulated in hepatocellular carcinoma (HCC) tissues, and its upregulation was associated with large tumor size, low differentiation, and shorter survival rates. Further results supports the hypothesis that S100A1 functions as an oncogene and may be a biomarker for the prognosis of patients with HCC. S100A1 exerted its oncogenic function by interacting with LATS1 and activating Hippo pathway. PMID: 29901195
3. The results indicate that changes in the circulating level of S100A1 protein occur in metabolic syndrome patients. The strong correlation between serum zinc-alpha2-glycoprotein and S100A1 might suggest that production or release of these two proteins could be related mechanistically. PMID: 28825380
4. The results indicated that S100A1 enhanced the ovarian cancer cell proliferation and migration. PMID: 28595036
5. found that S100B plays a crucial role in blocking the interaction site between RAGE V domain and S100A1. A cell proliferation assay WST-1 also supported our results. This report could potentially be useful for new protein development for cancer treatment PMID: 29444082
6. Study provides evidence that mir-363 and its target S100A1 are under the regulatory function of FOXD2-AS1 aggravating nasopharyngeal carcinoma carcinogenesis. PMID: 29248577
7. X-ray crystal structure of human calcium-bound S100A1 has been reported. PMID: 28368280
8. a molecular mechanism for the potential regulation of TRPM1 by S100A1 PMID: 27435061
9. Data suggest that calcium signaling plays important role in prevention of protein misfolding; complexes of S100A1 and STIP1 are key players in this pathway; the stoichiometry of S100A1/STIP1 interaction appears to be three S100A1 dimers plus one STIP1 monomer; each S100A1-STIP1-binding interaction is entropically driven. (S100A1 = S100 calcium binding protein A1; STIP1 = stress-induced-phosphoprotein 1) [REVIEW] PMID: 28819010
10. Data suggest that three dimers of S100A1 (S100 calcium binding protein A1) associate with one molecule of STIP1 (stress-inducible phosphoprotein 1) in a calcium-dependent manner; individual STIP1 TPR (tetratricopeptide repeat) domains, TPR1, TPR2A and TPR2B, bind a single S100A1 dimer with significantly different affinities; TPR2B domain possesses highest affinity for S100A1. PMID: 28408431
11. Results identified amino acids motif in S100A1 for protein binding to 2-oxohistidine which appears to be an evolutionarily conserved capacity from bacteria to human. PMID: 27644758
12. a correlation between S100B + A1-positive Human Articular Chondrocytes in monolayer culture and their neochondrogenesis capacity in pellet culture, is reported. PMID: 27861869
13. In line with these observations, rhesus monkey rhadinovirus infection resulted in rapid degradation of SP100, followed by degradation of PML and the loss of ND10 structures, whereas the protein levels of ATRX and DAXX remained constant. PMID: 27356898
14. High Serum protein S100 levels are associated with postoperative delirium after off-pump coronary artery bypass surgery. PMID: 26943607
15. molecular dynamics simulations of S100A1 in the apo/holo (Ca(2+)-free/bound) states, is reported. PMID: 26958883
16. The relationship between the degree of infiltration by S100-positive (S100+) dendritic cells and prognostic factors, including histological subtype, histological grade, peritumor inflammatory infiltration, and stromal desmoplasia, were examined. PMID: 25611268
17. In this review, we aim to describe the molecular basis and regulatory function of S100A1--{REVIEW} PMID: 25157660
18. Patients with acute myocardial infarction (MI) showed significantly increased S100A1 serum levels. S100A1 signaling in cardiac fibroblasts occurs through endosomal TLR4/MyD88. PMID: 24833748
19. hypoxia-induced MiR-138 is an essential mediator of EC dysfunction via its ability to target the 3'UTR of S100A1. PMID: 24244340
20. It was suggested that S100A1 and S100B be used as markers to develop potency assays for cartilage regeneration cell therapies, and as a redifferentiation readout in monolayer cultures aiming to investigate stimuli for chondrogenic induction. PMID: 24402969
21. Twenty-seven out of thirty-two (84.38%) cases of serous ovarian carcinoma were found to express S100A1. S100A1 expression was observed in one out of the two mucinous and three out of the six endometroid ovarian carcinomas. PMID: 24501865
22. The triple mutation Arg852/Lys859/Arg860 exhibited significant disruption of the binding of S100A1 to TRPC6 implicating their involvement in the binding site. PMID: 23671622
23. For autopsy material, all human cases of definite myocardial infarction and suspected early infarction showed well-defined areas without S100A1 staining. PMID: 23683996
24. This study showed that overexpression of S100A10, may play a role in irritable bowel syndrome, and that the IL10-819 CC is a candidate genotype for irritable bowel syndrome and ulcerative colitis. PMID: 23595519
25. In this review we will focus on the roles of S100A proteins in intracellular and extracellular calcium signalling and homeostasis. PMID: 23662436
26. the increased calcium binding affinity of S100A1 upon thionylation arises, most probably, from rearrangement of the hydrophobic core in its apo form PMID: 23351007
27. Report downregulation of S100A1 expression in critical limb ischemia impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. PMID: 23048072
28. S-Nitrosylation of S100A1 increases Ca(2+) binding and tunes the overall protein conformation. PMID: 22989881
29. Uremia clearance using NHD is accompanied by improvement in LV strain, rotation, reduction in mass and volume index. Dialysis downregulates genes for cardiomyocyte apoptosis and fibrosis and upregulates S100A1, which may improve LV contractility. PMID: 22647434
30. Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel. PMID: 22451665
31. The three-dimensional structure of human apo(calcium free)S100A1 protein was determined by NMR spectroscopy PMID: 21296671
32. Thermodynamics of zinc binding to human S100A2 PMID: 21090249
33. S100A1, S100A2, S100A4, S100A6 and S100B interacted with MDM2 (2-125). PMID: 20591429
34. A single phenyl-Sepharose column was sufficient for the purification of human S100A11 whereas HiTrap Q anion exchange followed by phenyl-Sepharose columns were required for the purification of S100A1. PMID: 20347987
35. The expression of S100A1 was low in benign melanocytic tumours and increased in malignant melanomas PMID: 20042890
36. S100A1B and S100BB are increased in urine collected from asphyxiated newborns who will develop hypoxic-ischemic encephalopathy (HIE) since first urination, and their measurement may be useful to early predict HIE. PMID: 19482672
37. S100A1 is a specific and sensitive immunohistochemical marker to differentiate nephrogenic adenoma from prostatic adenocarcinoma PMID: 19384190
38. The presence of the S100A1 in myocardial sarcoplasmic reticulum and myofibrils may be related to the known target proteins for S100A1 at these sites. PMID: 11829317
39. Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. PMID: 11909974
40. identification of the S100A1 C terminus (amino acids 75-94) and hinge region (amino acids 42-54) to differentially enhance sarcoplasmic reticulum Ca2+ release with a nearly 3-fold higher activity of the C terminus PMID: 12721284
41. S100A1 has a reglatory role in the contraction-relaxation cycle in the human heart PMID: 12804600
42. S100A1 protein serves as a cardioprotective factor in vitro PMID: 12960148
43. identified S100A1, but not calmodulin or other S100 proteins, as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex PMID: 14638689
44. Synapsins and S100A1 interact in nerve terminals where coexpresssed; S100A1 cannot bind SV-associated synapsin I and may function as a cytoplasmic store of monomeric synapsin I; synapsin dimerization and interaction with S100A1 are mutually exclusive PMID: 15147519
45. Results demonstrate that restoration of S100A1 protein levels in failing myocardium by gene transfer may be a novel therapeutic strategy for the treatment of heart failure. PMID: 15578088
46. This study provides the first evidence that intracellular S100A1, depending on its subcellular location, modulates cardiac Ca2+-turnover via different Ca2+-regulatory proteins. PMID: 15654019
47. S100A1 was expressed in 2/15 clear cell RCCs, 11/15 papillary RCCs, 7/8 oncocytomas and in 0/7 chromophobe RCCs. PMID: 15780567
48. the three-dimensional structure of calcium-bound S100A1 was determined by multidimensional NMR spectroscopy and compared to the previously determined structure of apo-S100A1 PMID: 16169012
49. S-100 protein expression in tumour cells was associated with significantly decreased survival PMID: 16760135
50. analysis of the different reactivity pattern of S100A1 in the external auditory canal cholesteatoma PMID: 16969478

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Cytoplasm. Sarcoplasmic reticulum. Mitochondrion.

S-100 family

Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.

HGNC: 10486

OMIM: 176940

KEGG: hsa:6271

STRING: 9606.ENSP00000292169

UniGene: Hs.515715