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  4. Human Semaphorin-3D(SEMA3D) ELISA kit

Human Semaphorin-3D(SEMA3D) ELISA kit

  • 中文名称：
    人臂板蛋白-3D(SEMA3D)酶联免疫试剂盒
  • 货号：
    CSB-EL020983HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human SEMA3D ELISA Kit was designed for the quantitative measurement of Human SEMA3D protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.312 ng/mL-20 ng/mL and the sensitivity is 0.078 ng/mL.

  • 别名：
    Coll 2 ELISA Kit; Coll2 ELISA Kit; Collapsin 2 ELISA Kit; SEM3D_HUMAN ELISA Kit; Sema domain immunoglobulin domain (Ig) short basic domain secreted (semaphorin) 3D ELISA Kit; Sema Z2 ELISA Kit; Sema3d ELISA Kit; Semaphorin-3D ELISA Kit; Semaphorin3D ELISA Kit
  • 缩写：
    SEMA3D
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.312 ng/mL-20 ng/mL
  • 灵敏度：
    0.078 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Neuroscience
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin.
  • 基因功能参考文献：
    1. Low SEMA3D expression is associated with colorectal cancer. PMID: 28320475
    2. Novel mutation in SEMA3D segregates with the complete phenotype with variable expressivity in two pedigrees with autosomal dominant familial Meniere's disease. PMID: 27876815
    3. Data show significant increases in semaphorin3C, 3D and their receptor neuropilin-2 in degenerate samples which were shown to contain nerves and blood vessels, compared to non-degenerate samples without nerves and blood vessels. PMID: 26286962
    4. CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies PMID: 26073756
    5. Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. PMID: 25839327
    6. Semaphorin 3d requires neuropilin 1 or PI3K/Akt, whereas semaphorin 3e requires plexin D1 in directing endothelial motility. PMID: 24825896
    7. In the absence of Sema3d, endothelial tubes form in a region that is normally avascular PMID: 23685842
    8. in this study we have analyzed three aminoacidic substitutions, A131T-SEMA3A, S598G-SEMA3A and E198K-SEMA3D. These variants result in an increase of SEMA proteins levels in the HSCR colon tissue. PMID: 23372769
    9. This study provided strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder. PMID: 20684831
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 20684831
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19054571
    12. Sema3D inhibits tumor development from MDA-MB-231 and MDA-MB-435 cancer cells. It inhibits tumor angiogenesis in all of the formed tumors. PMID: 18818766

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Semaphorin family
  • 数据库链接：

    HGNC: 10726

    OMIM: 609907

    KEGG: hsa:223117

    STRING: 9606.ENSP00000284136

    UniGene: Hs.201340