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  4. Human Reticulon-4 receptor-like 2(RTN4RL2) ELISA kit

Human Reticulon-4 receptor-like 2(RTN4RL2) ELISA kit

  • 中文名称：
    人网状蛋白4受体样蛋白2(RTN4RL2)酶联免疫试剂盒
  • 货号：
    CSB-EL020576HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human RTN4RL2 ELISA Kit was designed for the quantitative measurement of Human RTN4RL2 protein in serum, plasma, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 0.156 ng/mL-10 ng/mL and the sensitivity is 0.039 ng/mL.

  • 别名：
    RTN4RL2 ELISA Kit; NGRH1 ELISA Kit; NGRL3 ELISA Kit; Reticulon-4 receptor-like 2 ELISA Kit; Nogo receptor-like 3 ELISA Kit; Nogo-66 receptor homolog 1 ELISA Kit; Nogo-66 receptor-related protein 2 ELISA Kit; NgR2 ELISA Kit
  • 缩写：
    RTN4RL2
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates, cell lysates
  • 检测范围：
    0.156 ng/mL-10 ng/mL
  • 灵敏度：
    0.039 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Neuroscience
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human RTN4RL2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %97
    Range %90-106
    1:2Average %95
    Range %85-104
    1:4Average %95
    Range %86-100
    1:8Average %96
    Range %88-109
  • 回收率：
    The recovery of human RTN4RL2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9684-107
    EDTA plasma (n=4)9290-95
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.081 2.017 2.049 1.947
    51.777 1.758 1.768 1.666
    2.51.337 1.326 1.332 1.230
    1.250.826 0.849 0.838 0.736
    0.6250.517 0.531 0.524 0.422
    0.3120.338 0.345 0.342 0.240
    0.1560.273 0.289 0.281 0.179
    00.103 0.101 0.102
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.
  • 基因功能参考文献：
    1. s highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review] PMID: 24956133
    2. These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. PMID: 21906273
    3. predominantly expressed in the neurons of the embryonic and adult nervous systems PMID: 14664809
    4. The release of N-terminal fragment-NgRH1 was blocked by a hydroxamate-based zinc metalloproteinase inhibitor and tissue inhibitor of metalloproteinases-2 and -3 PMID: 15629437
    5. Nogo-66 receptor homolog 1 signaling regulates activity-dependent synaptic strength and neuronal plasticity. PMID: 18337405

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Perikaryon. Cell projection, axon.
  • 蛋白家族：
    Nogo receptor family
  • 组织特异性：
    Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
  • 数据库链接：

    HGNC: 23053

    OMIM: 610462

    KEGG: hsa:349667

    STRING: 9606.ENSP00000335397

    UniGene: Hs.502618