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  4. Human Myeloid Progenitor Inhibitory Factor 1,MPIF-1 ELISA Kit

Human Myeloid Progenitor Inhibitory Factor 1,MPIF-1 ELISA Kit

  • 中文名称：
    人骨髓抑制因子1(MPIF-1/CCL23)酶联免疫试剂盒
  • 货号：
    CSB-E07309h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        CCL23，也称为炎性细胞趋化蛋白-3（MIP-3），是C-C趋化因子家族中的一种趋化因子。它主要由树突状细胞、红细胞和巨噬细胞等产生，并且能够吸引CCR1和CCR5受体表达的细胞，如单核细胞、记忆性T细胞和巨噬细胞等。CCL23在多种炎症和免疫调节过程中发挥着重要作用，如哮喘、风湿性关节炎等。
        j9九游会登录入口首页生物所提供的Human Myeloid Progenitor Inhibitory Factor 1,MPIF-1 ELISA Kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、组织匀浆样本中的CCL23，其灵敏度为9.7 pg/mL，检测范围为39 pg/mL-2500 pg/mL。
     
  • 别名：
    C C motif chemokine ligand 23 ELISA Kit; C-C motif chemokine 23 ELISA Kit; C6 beta chemokine ELISA Kit; CCL 23 ELISA Kit; CCL23 ELISA Kit; CCL23(30-99) ELISA Kit; CCL23_HUMAN ELISA Kit; Chemokine (C C motif) ligand 23 ELISA Kit; Chemokine CC motif ligand 23 ELISA Kit; ck beta 8 ELISA Kit; CK-beta-8 ELISA Kit; CKB 8 ELISA Kit; CKB-8 ELISA Kit; Ckb-8-1 ELISA Kit; CKB8 ELISA Kit; Hmrp-2a ELISA Kit; Macrophage inflammatory protein 3 ELISA Kit; MIP 3 ELISA Kit; MIP-3 ELISA Kit; MIP3 ELISA Kit; MPIF 1 ELISA Kit; MPIF-1 ELISA Kit; MPIF1 ELISA Kit; Myeloid progenitor inhibitory factor 1 ELISA Kit; OTTHUMP00000163948 ELISA Kit; SCYA 23 ELISA Kit; SCYA23 ELISA Kit; Small inducible cytokine A 23 ELISA Kit; Small inducible cytokine subfamily A (Cys-Cys); member 23 ELISA Kit; Small inducible cytokine subfamily A; member 23 ELISA Kit; Small-inducible cytokine A23 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    39 pg/mL-2500 pg/mL
  • 灵敏度：
    9.7 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
        CCL23是一种趋化因子，已被证明在多种疾病中发挥重要作用，如哮喘、肺癌和自身免疫性疾病等。研究表明，CCL23在哮喘和COPD患者中的含量显著增加，并且与疾病的严重程度呈正相关。此外，最近的研究表明，CCL23可以促进肿瘤细胞增殖和转移，因此可能是治疗肿瘤的潜在靶点。
     
  • 功能：
    Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
  • 基因功能参考文献：
    1. CCL23 is posttranslationally modified by trypsin-like serine proteases and CCL23(47-117) might be a major active form of CCL23 in nasal polyps with chronic rhinosinusitis. PMID: 26560043
    2. The coexistence of diabetes and oxidative stress independently affected CCL23 levels, while the presence of Cardiovascular disease and inflammation had no impact on its concentrations. PMID: 24995525
    3. ADAMTS 8, CCL23, and TNFSF15 are implicated in anti-angiogenic activities PMID: 24384427
    4. Data show CCL23 stimulates chemotaxis of human THP-1 monocytes and enhances release of MMP-2, and suggest it plays a role in atherogenesis. PMID: 21656154
    5. Overproduction of CCL23 in nasal polyps might contribute to the pathogenesis of eosinophilic chronic rhinosinusitis with nasal polyps PMID: 21497884
    6. Patients with systemic sclerosis who had elevated CCL23 levels had shorter disease duration, and a higher frequency of pulmonary arterial hypertension. Serum CCL23 level was increased in early phase of disease and could be a marker for disease activity. PMID: 20824279
    7. Fresh eosinophils contained trace amounts of CCL23 protein. CCL23 was significantly released into the supernatant when the eosinophils were stimulated with GM-CSF or IL-5 but not with IFN-gamma or immobilized sIgA. PMID: 21646793
    8. independently associated with coronary atherosclerosis PMID: 20187767
    9. CKbeta8 transduces the chemotaxis signal through the G(i)/G(o) protein, phospholipase C, protein kinase C delta and NF-kappaB. PMID: 19951712
    10. CCL23 promoted chemotactic migration and differentiation of endothelial cells, and neovascularization in the chick chorioallantoic membrane PMID: 15927850
    11. May play a direct role in angiogenesis via upregulation of matrix metalloproteinase (MMP)-2 expression. PMID: 16378600
    12. Collectively, these data suggest a link between the inducible phenotype of CCL23 expression in monocytes by the prototype Th2 molecule pair IL-4/STAT6 and the increased number of CCL23-expressing cells in skin of atopic dermatitis patients. PMID: 17371990
    13. A peptide ligand termed SHAAGtide is cleaved from CCL23; is itself an attractant of monocytes and neutrophils in vitro; recruits leukocytes in vivo; is more potent than other natural agents with activity for FPRL1; receives s' designation "CCR12." PMID: 17513790
    14. This protein may participate in the malignant progression of certain human cancer cells that overexpress ErbB2 through the transactivation of ErbB2 tyrosine kinase. PMID: 18258606
    15. CCL23, M-CSF, TNFRSF9, TNF-alpha, and CXCL13 are predictive of rheumatoid arthritis disease activity and may be useful in the definition of disease subphenotypes and in the measurement of response to therapy in clinical studies. PMID: 18668547
    16. these findings suggest that CCL23 results in up-regulation of KDR/flk-1 receptor gene transcription and protein expression and that KDR/Flk-1 up-regulation induced by CCL23 may contribute to potentiation of VEGF action in angiogenesis. PMID: 19265684

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CC
  • 数据库链接：

    HGNC: 10622

    OMIM: 602494

    KEGG: hsa:6368

    UniGene: Hs.169191