Human Mucin-4(MUC4) ELISA kit

Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.

1. MUC4 immunohistochemistry is useful for differentiation of epithelioid mesothelioma from lung carcinoma, either adenocarcinoma or squamous cell carcinoma. PMID: 29317712
2. These findings highlight a new role for Galectin 3 as a non-classic RNA-binding protein that regulates MUC4 mRNA post-transcriptionally. PMID: 28262838
3. The detection of MUC4 and/or MUC6 might be a powerful parameter in the clinical management of mucoepidermoid carcinoma in the early postsurgical phase. PMID: 28649694
4. High MUC4 expression is associated with Invasive micropapillary carcinoma of the breast. PMID: 29281999
5. MUC4/X facilitated pancreatic cancer (PC) tumorigenesis via integrin-beta1/FAK/ERK signaling pathway. Overall, these findings revealed the novel role of MUC4/X in promoting and sustaining the oncogenic features of PC. PMID: 29777904
6. auranofin could regulate the Her2/Akt/FOXO3 signaling pathway in SKOV3 cells and be used as a potential antitumor agent considering the expression of MUC4 in ovarian cancer patients. PMID: 28765909
7. TNFalpha induced upregulation of MUC4 that reduced trastuzumab binding to its epitope and impaired ADCC. Silencing MUC4 enhanced trastuzumab binding, increased ADCC, and overcame trastuzumab and trastuzumab-emtansine antiproliferative effects in TNFalpha-overexpressing cells. In HER2-positive breast cancer samples, MUC4 expression was found to be an independent predictor of poor disease-free survival. PMID: 27698002
8. MUC4 is a novel and useful negative immunohistochemical marker for differentiating sarcomatoid mesothelioma from lung sarcomatoid carcinoma PMID: 28128276
9. NIDO, AMOP and vWD domains of MUC4 play synergic roles in MUC4 mediated signaling in pancreatic cancer cells. PMID: 28060749
10. Study provides evidence that AMOP domain plays the key role in MUC4-mediated tumor angiogenesis and metastasis of pancreatic cancer cells partly through the NOTCH3 signaling and its downstream target genes: VEGF-A, MMP-9 and ANG-2. PMID: 27287498
11. elevated levels of bile acid increase the tumorigenic potential of pancreatic cancer cells by inducing FXR/FAK/c-Jun axis to upregulate MUC4 expression. PMID: 27185392
12. High MUC4 expression is associated with CRLF2-rearranged acute lymphoblastic leukemia. PMID: 28866095
13. Low expression of MUC4 was associated with favorable survival, whereas high MUC4 expression did not correlate with survival in resectable pancreatic cancer patients receiving adjuvant gemcitabine treatment. PMID: 28270046
14. the present study provides evidence that hypoxia negatively regulates MUC4 expression in PC by affecting its stability. PMID: 27109098
15. Studies indicate that a positive or high expression level of mucin 4 (MUC4) was significantly related to poor survival in patients with resected cholangiocarcinoma (CC). PMID: 27305093
16. MUC4beta participates in the corticosteroid resistance process, inhibiting normal GRalpha nuclear function. The high expression of MUC4 in patients with CRSwNP might participate in corticosteroid resistance. PMID: 27639937
17. Data indicate that microRNA miR-211 can directly target the 3'UTR of mucin-4 (MUC4) and inhibit its expression at both mRNA and protein levels. PMID: 27923652
18. The main significance of this work is the discovery of EPO as a novel ligand for the HER2 receptor. Following HER2 activation, EPO induces activation of FAK and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 and a sustained up regulation of both MUC4 and the HER2 receptor PMID: 27519953
19. MUC4 promotes the migration and proliferation of BxPC-3 cells. PMID: 27748843
20. The prognostic accuracy of TNM stage, UCLA Integrated Scoring System (UISS), and Mayo clinic stage, size, grade, and necrosis score (SSIGN) prognostic models was improved when MUC4 expression was added. PMID: 27124015
21. High MUC4 expression is associated with colorectal cancer cell migration and invasion. PMID: 25124610
22. s show for the first time that beta-catenin directly governs MUC4 in pancreatic cancer. PMID: 26526617
23. High MUC4 expression is associated wit response to chemotherapy in esophageal squamous cell carcinoma. PMID: 26673820
24. The most highly up-regulated gene was mucin 4 (MUC4), and its protein product was confirmed to be over-expressed in periodontitis PMID: 26686060
25. MUC4 has a role in promoting neural invasion mediated by the axon guidance factor Netrin-1 in pancreatic ductal adenocarcinoma PMID: 26393880
26. Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients. PMID: 25923310
27. HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells PMID: 26035354
28. repressing MUC4 transcription, inhibiting post-transcriptional regulation, including alternative splicing, or blocking various pathways simultaneously may be helpful for controlling malignant progression PMID: 25367394
29. Transfection of constitutively activated K-rasG12V in pancreatic cancer cells led to the transcriptional upregulation of MUC4 at the transcriptional level by AP-1, MAPK, JNK and NF-kappaB pathways and at the posttranscriptional level by RalB GTPase. PMID: 26477488
30. This epigenome-wide DNA methylation analysis in postmortem hippocampus and prefrontal cortex specimens confirmed MUC4 DNA methylation profiles in major depression. PMID: 25571874
31. High MUC4 expression is associated with pancreatic cancer. PMID: 25686822
32. miR-150 is an important suppressor of pancreatic ductal carcinoma and acts as a regulator of c-Myb and MUC4 in aggressive progress. PMID: 25522282
33. reduced protein expression in breast epithelium correlates with breast cancer progression, increased tumor-infiltrating CD8+ T and NK cells and promoter hypermethylation PMID: 24992172
34. Orthotopic implantation of MUC4 KD SCC1 cells into the floor of the mouth in nude mice resulted in the formation of significantly smaller tumors PMID: 24747969
35. these results identify miR-219-1-3p as a new negative regulator of MUC4 oncomucin that possesses tumor-suppressor activity in Pancreatic ductal adenocarcinoma PMID: 24608432
36. These results suggest that MUC4/Y promotes tumour progression through its anti-apoptotic and weak mitogenic effect the pancreatic cancer cell line MIA PaCa-2. PMID: 24676527
37. MUC4 expression in GBM was important in GBM cell proliferation and invasion, which may be partly associated with EGFR overexpression. PMID: 24582898
38. This study delineates the association and the downstream mechanisms of MUC4-regulated elevation of lipocalin-2 and its clinical significance for prognosis of pancreatic cancer. PMID: 24240113
39. MUC4 was expressed in 42%, 100% each and 50% in non-goblet columnar lined oesophagus, Barrett's oesophagus, high grade dysplasia and adenocarcinoma respectively. PMID: 24290871
40. MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer. PMID: 24204560
41. MUC4 gene polymorphisms and their interaction with smoking may contribute to lung cancer etiology. PMID: 24204934
42. Higher expression of MUC4 in intestinal-type intraductal papillary mucinous pancreatic neoplasm (IPMN) than in gastric-type IPMN discriminates between intestinal-type IPMN with high malignancy potential from gastric-type IPMN with low malignancy potential PMID: 23921963
43. MUC4 was observed in both primary pancreatic ductal adenocarcinoma (PDAC) tumors and matched lymph node metastases with a high level of concordance, suggesting that MUC4 expression is retained following PDAC metastasis. PMID: 24047396
44. our study reveals a novel role for MUC4 in suppressing EMT and suggests that the assessment of MUC4 may function as a prognostic biomarker and could be a potential therapeutic target for lung adenocarcinoma metastasis. PMID: 24037917
45. MUC4-induced nuclear translocation of beta-catenin is a novel mechanism for growth, metastasis and angiogenesis of pancreatic cancer. PMID: 24374017
46. In addition, absence of MUC4 expression is the definitive key to distinguish IM from LGFMS. PMID: 23685711
47. primary bone tumours rarely express MUC4 PMID: 23668430
48. Our data suggest that MUC4 appears to be a sensitive and specific marker for differentiating between metastatic adenocarcinoma cells and reactive mesothelial cells in effusion fluids PMID: 23860190
49. Data indicate that HDAC inhibitor targeting of HNF-4alpha may serve as an effective treatment for advanced colon carcinomas, since downstream cancer-associated target genes such as MUC4 are significantly down-regulated by this treatment. PMID: 23307400
50. Loss of MUC4 expression is associated with non-small-cell lung cancer. PMID: 23370366

显示更多

收起更多

[Mucin-4 beta chain]: Cell membrane; Single-pass membrane protein.; [Mucin-4 alpha chain]: Cell membrane. Secreted.; [Isoform 3]: Cell membrane; Single-pass membrane protein.; [Isoform 11]: Secreted.; [Isoform 15]: Secreted.; [Isoform 17]: Cell membrane; Single-pass membrane protein.

Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, sq

HGNC: 7514

OMIM: 158372

KEGG: hsa:4585

STRING: 9606.ENSP00000417498

UniGene: Hs.369646