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  4. Human Leukocyte immunoglobulin-like receptor subfamily A member 3(LILRA3) ELISA kit

Human Leukocyte immunoglobulin-like receptor subfamily A member 3(LILRA3) ELISA kit

  • 中文名称：
    人白细胞免疫球蛋白样受体亚家族A成员3(LILRA3)酶联免疫试剂盒
  • 货号：
    CSB-EL012935HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human LILRA3 ELISA Kit was designed for the quantitative measurement of Human LILRA3 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.156 ng/mL-10 ng/mL and the sensitivity is 0.039 ng/mL .

  • 别名：
    CD 85E ELISA Kit; CD85 antigen-like family member E ELISA Kit; CD85e ELISA Kit; CD85e antigen ELISA Kit; e3 ELISA Kit; HM 31 ELISA Kit; HM 43 ELISA Kit; HM31 ELISA Kit; HM43 ELISA Kit; ILT 6 ELISA Kit; ILT-6 ELISA Kit; ILT6 ELISA Kit; Immunoglobulin like transcript 6 ELISA Kit; Immunoglobulin-like transcript 6 ELISA Kit; Leucocyte immunoglobulin like receptor ELISA Kit; Leukocyte immunoglobulin like receptor 4 ELISA Kit; Leukocyte immunoglobulin like receptor A3 ELISA Kit; Leukocyte immunoglobulin like receptor subfamily A (without TM domain) member 3 ELISA Kit; Leukocyte immunoglobulin like receptor subfamily A member 3 ELISA Kit; Leukocyte immunoglobulin-like receptor 4 ELISA Kit; Leukocyte immunoglobulin-like receptor subfamily A member 3 ELISA Kit; LILRA 3 ELISA Kit; LILRA3 ELISA Kit; LIR 4 ELISA Kit; LIR-4 ELISA Kit; LIR4 ELISA Kit; LIRA3_HUMAN ELISA Kit; Monocyte inhibitory receptor HM43/HM31 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.156 ng/mL-10 ng/mL
  • 灵敏度：
    0.039 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human LILRA3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %87
    Range %80-94
    1:2Average %95
    Range %91-103
    1:4Average %102
    Range %96-108
    1:8Average %95
    Range %88-100
  • 回收率：
    The recovery of human LILRA3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9789-104
    EDTA plasma (n=4)9690-100
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.197 2.099 2.148 2.056
    51.349 1.425 1.387 1.295
    2.50.904 0.926 0.915 0.823
    1.250.577 0.603 0.590 0.498
    0.6250.410 0.404 0.407 0.315
    0.3120.255 0.254 0.255 0.163
    0.1560.178 0.174 0.176 0.084
    00.092 0.091 0.092 　
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
  • 基因功能参考文献：
    1. Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc. PMID: 24891332
    2. The homozygous LILRA3 deletion is associated with a higher susceptibility for HIV disease and with a faster disease progression. PMID: 27755104
    3. Letter: LILRA3 gene deletion is not involved in the giant cell arteritis and systemic sclerosis predisposition in Spanish patients. PMID: 27462831
    4. LILRA3 significantly reversed Nogo-66-mediated inhibition of neurite outgrowth and promoted synapse formation in primary cortical neurons through regulation of the ERK/MEK pathway. PMID: 26826187
    5. Experiments point towards a beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8; however, the potentially beneficial role of LILRA3 is abrogated during a HIV infection. PMID: 26969150
    6. LILRA3 gene deletion was not associated with Multiple Sclerosis susceptibility and did not affect the age of disease onset, clinical subtype or disease severity. PMID: 26871720
    7. Evidence showed lack of significant association between LILRA3 deletion and multiple sclerosis pathogenesis. [meta-analysis] PMID: 26274821
    8. LILRA3 is a new susceptibility factor for systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS). It predisposes to certain phenotypes such as leucopenia, thrombocytopenia, autoantibody positivity and increased disease activity. PMID: 24906639
    9. The current study was conducted to investigate the association of rs103294 of LILRA3 with benign prostatic hyperplasia risk. PMID: 23615473
    10. ILT6 deletion polymorphism does not appear to be a lupus susceptibility gene in South Indian Tamils, but may behave as a genetic modifier of autoantibody phenotype by influencing the production of anti-Ro60 and anti-Ro52 autoantibodies PMID: 24899637
    11. LILRA3 is an immunostimulatory molecule, whose deficiency is associated with higher frequency of B-non-Hodgkin's lymphoma. PMID: 24363809
    12. functional LILRA3 is a novel genetic risk factor for rheumatoid arthritis (RA), especially in males. It appears to highly predispose to ACPA-positive RA and confers an increased risk of disease severity in patients with early RA. PMID: 24757135
    13. Data did not indicate any association of LILRA3 deletion with multiple sclerosis (MS) susceptibility, however, patients negative for the deletion may begin to suffer from MS significantly earlier than patients who are positive. PMID: 23238213
    14. LILRA1 and LILRA3 generally display a greater binding preference for binding to HLA-C free heavy chain, particularly following removal of beta2-microglobulin by acid treatment. PMID: 21270408
    15. These results suggest that LILRA3 may play a role in chronic inflammatory conditions such as rheumatoid arthritis. PMID: 20595277
    16. A deletion of LILRA3 gene was found in a minority of British population PMID: 12651072
    17. Six alleles characterised, of which four will encode unique peptides, one of which is likely to directly influence ligand binding. PMID: 12750859
    18. Multiple sclerosis associates with LILRA3 deletion. PMID: 19421224
    19. ILT6 deficiency may be a genetic risk factor for Sjogren's syndrome. PMID: 19790059

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
  • 数据库链接：

    HGNC: 6604

    OMIM: 604818

    KEGG: hsa:11026

    STRING: 9606.ENSP00000251390

    UniGene: Hs.113277