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  4. Human Interleukin-36 receptor antagonist protein(IL1F5) ELISA kit

Human Interleukin-36 receptor antagonist protein(IL1F5) ELISA kit

  • 中文名称：
    人白介素-36受体拮抗蛋白(IL1F5)酶联免疫试剂盒
  • 货号：
    CSB-EL011616HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    The product CSB-EL011616HU is a sandwich ELISA kit developed to measure levels of human interleukin-36 receptor antagonist protein (IL-36Ra) in serum, plasma, or tissue homogenates. The enzyme-substrate chromogenic reaction is also used to amplify the signal and quantify the levels of the analyte through the intensity of the colored product. The color intensity positively correlates with the amount of IL1F5 bound in the initial step.

    IL-36Ra, also called IL1F5, functions as a receptor antagonist that inhibits the activation of IL-36R signaling. It induces inflammatory responses by activating NF-κB and MAPKs via an intracellular signaling cascade. In contrast, IL-36Ra suppresses pro-inflammatory signaling by binding to and inhibiting IL-36R activation. It is highly expressed in the skin, brain, tonsils, spleen, and various immune cell types such as macrophages, monocytes, B cells, and dendritic cells (DCs). Loss-of-function homozygous or compound heterozygous mutations in its encoding gene IL36RN have been implicated in the pathogenesis of various skin disorders.

  • 别名：
    AI413231 ELISA Kit; Family of interleukin 1 delta ELISA Kit; FIL1 ELISA Kit; FIL1 delta ELISA Kit; FIL1(DELTA) ELISA Kit; FIL1D ELISA Kit; Fil1delta ELISA Kit; I36RA_HUMAN ELISA Kit; IL 1 delta ELISA Kit; IL 1 related protein 3 ELISA Kit; IL 1F5 (IL 1HY1, FIL1 delta, IL 1RP3, IL 1L1, IL 1 delta) ELISA Kit; Il 1h3 ELISA Kit; IL 1HY1 ELISA Kit; IL 1L1 ELISA Kit; IL 1ra homolog ELISA Kit; IL 1ra homolog, IL1F5 (Canonical product IL 1F5a) ELISA Kit; IL 1RP3 ELISA Kit; IL-1 delta ELISA Kit; IL-1-related protein 3 ELISA Kit; IL-1F5 ELISA Kit; IL-1HY1 ELISA Kit; IL-1L1 ELISA Kit; IL-1ra homolog 1 ELISA Kit; IL-1RP3 ELISA Kit; IL1F5 ELISA Kit; IL1HY1 ELISA Kit; IL1L1 ELISA Kit; IL1RP3 ELISA Kit; IL36RA ELISA Kit; IL36RN ELISA Kit; Interleukin 1 delta ELISA Kit; Interleukin 1 family member 5 (delta) ELISA Kit; Interleukin 1 family member 5 ELISA Kit; Interleukin 1 HY1 ELISA Kit; Interleukin 1 like protein 1 ELISA Kit; Interleukin 1 receptor antagonist homolog 1 ELISA Kit; Interleukin 36 receptor antagonist ELISA Kit; Interleukin-1 delta ELISA Kit; Interleukin-1 family member 5 ELISA Kit; Interleukin-1 HY1 ELISA Kit; Interleukin-1 receptor antagonist homolog 1 ELISA Kit; Interleukin-1-like protein 1 ELISA Kit; Interleukin-36 receptor antagonist protein ELISA Kit; MGC29840 ELISA Kit; PSORP ELISA Kit; RP23-176J12.6 ELISA Kit
  • 缩写：
    IL1F5
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    31.25 pg/ml - 2000 pg/ml
  • 灵敏度：
    7.8 pg/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
  • 基因功能参考文献：
    1. systemic lupus erythematosus patients had significantly decreased serum IL-36Ra levels PMID: 29571080
    2. IL36RN may be the major disease-causing gene in generalized pustular psoriasis patients in Han population in Sichuan region of China. PMID: 30075588
    3. IL36RN mutations were strongly linked with early onset and hyponychial pustules, but not with therapeutic efficacy of acitretin or recurrence frequency. Early onset and hyponychial pustules may be specific to IL36RN mutation, however this alone is an insufficient biomarker for acitretin therapy. PMID: 29619998
    4. Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the s have identified that neutrophil elastase, but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form. PMID: 27101808
    5. A study on the association of IL36RN mutations that affect protein expression and function with phenotype in patients with generalized pustular psoriasis. PMID: 27220475
    6. The findings indicate that IL36RN mutations do not seem to contribute to the pathogenesis of common, nonpustular forms of psoriasis, but to the rarer pustular manifestations such as GPP, acrodermatitis continua suppurativa of Hallopeau and acute generalized exanthematous pustulosis. PMID: 27038307
    7. Some cases of geographic tongue are caused by IL36RN mutations, while those lacking mutations are associated with an imbalance in expression between IL-36Ra and IL-36gamma proteins in tongue tissue. PMID: 27900482
    8. Study data and the previous European study suggest that palmoplantar pustulosis is not associated with mutations of the IL36RN gene. PMID: 27542682
    9. Case Report: short-term infliximab for treatment of juvenile generalized pustular psoriasis with IL36RN mutation. PMID: 26627198
    10. The s present a case of strikingly distinct phenotypes seen in two IL36RN mutation carriers from the same nonconsanguineous pedigree. This mutation it appears may influence the age of onset. PMID: 26147717
    11. The present study identified IL-36RN in various species and investigated the associations between IL-36RN and cancer prognosis. PMID: 26676204
    12. We identified a novel homozygous missense mutation in IL36RN in two siblings, and showed the molecular basis of the condition to be both distinct from psoriasis and distinct between the two families studied. PMID: 25688670
    13. generalized pustular psoriasis and early onset, ever generalized pustular psoriasis (more than two attacks), ever acrodermatitis continua of Hallopeau, inverse psoriasis, and a family history of pustular psoriasis were associated with IL36RN mutation. PMID: 26589685
    14. IL36RN was identified as strong regulators of skin pathology in both lesional and non-lesional skin samples. PMID: 25897967
    15. IL36RN missense mutation was not associated with psoriasis. PMID: 25989471
    16. we report T123M and 115+6T>C mutations, both homozygous in nature, in two Japanese individuals with Zumbusch type of generalized pustular psoriasis. PMID: 25615897
    17. found 2 new variants and 4 known IL36RN variants in 29 generalized pustular psoriasis patients PMID: 25212972
    18. identified a novel IL36RN missense mutation, c.334G > A in exon 5, that caused p.E112K substitution and was located adjacent to a 113 amino acid residue in generalized pustular psoriasis PMID: 25468355
    19. The study found that IL36RN alleles define a generalized pustular psoriasis phenotype characterized by early onset, high risk of systemic inflammation, and low prevalence of psoriasis vulgaris. PMID: 25458002
    20. in a Chinese Daur family with generalized pustular psoriasis, identified a homozygous splice site mutation c.115+6T>C in intron 3 in both patients; other 4 family members and 7 healthy controls carried heterozygous c.115+6T>C mutations PMID: 24979538
    21. Individuals with IL36RN mutations are very susceptible to Generalized pustular psoriasis (GPP) or GPP-related generalized pustulosis induced by drugs. [review] PMID: 24656634
    22. We report two cases of impetigo herpetiformis with homozygous and heterozygous IL36RN mutations. PMID: 24717243
    23. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin PMID: 24829417
    24. IL36RN variants are unlikely to confer significant disease risk for psoriasis vulgaris. PMID: 23792462
    25. Acrodermatitis is a clinical phenotype of DITRA: evidence a variant of pustular psoriasis... recessively inherited mutations in the IL36RN gene, which encodes interleukin-36 receptor antagonist... the cause of familial GPP, a condition termed DITRA PMID: 23428889
    26. The majority of generalized pustular psoriasis alone is caused by deficiency of the interleukin-36 receptor antagonist due to IL36RN mutations. PMID: 23698098
    27. The percentage of IL36RN mutations of pediatric generalized pustular psoriasis patients was much higher than that of adult onset patients. PMID: 23863864
    28. Our rate of 38.9% IL36RN mutations provides further evidence that generalized pustular psoriasis is heterogenous. PMID: 23648549
    29. IL36RN missense mutations may underlie some forms of acute generalized exanthematous pustulosis. PMID: 23358093
    30. Results indicate that IL36RN mutations are not associated with pustular psoriasis in Chinese populations. PMID: 22862555
    31. Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes. PMID: 23303454
    32. Data indicate that IL36RN mutations were identified in 2 of 14 Japanese generalized pustular psoriasis (GPP) patients. PMID: 22903787
    33. The mutation in the interleukin-36-receptor antagonist gene plays a role in generalised pustular psoriasis PMID: 22325761
    34. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra. PMID: 22315422
    35. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity PMID: 21965679
    36. Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. PMID: 21839423
    37. Expression of IL-1F5 is increased in human plaque psoriasis skin and is overexpressed in the lesional psoriatic skin of transgenic mice. PMID: 21242515
    38. results suggest that polymorphisms within IL1RN and IL1L1 themselves or a gene in linkage disequilibrium with IL1RN and IL1L1 predispose to the more severe forms of alopecia areata PMID: 11841485
    39. The commnon variants in the IL-1 cluster gene are not associated with incidence of restenosis in patients after PTCA. PMID: 14644395
    40. IL-1beta-511T was associated with reflux esophagitis having hyperacidity. PMID: 16211343
    41. Data show that the gene expression for interleukin-8, IL-10, and IL-1Ra, but not IL-6, is increased in blood leukocytes taken from athletes following 2 hours of intensive cycling and is not influenced by carbohydrate compared with placebo ingestion. PMID: 16978071
    42. IL-1 delta, which shows striking homology to IL-1 receptor antagonist, specifically and potently inhibits NF-kappa B activation through the orphan IL-1 receptor-related protein 2. PMID: 11466363

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  • 相关疾病：
    Psoriasis 14, pustular (PSORS14)
  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 组织特异性：
    Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
  • 数据库链接：

    HGNC: 15561

    OMIM: 605507

    KEGG: hsa:26525

    STRING: 9606.ENSP00000259212

    UniGene: Hs.516301