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  4. Human Fibroblast growth factor 20(FGF20) ELISA kit

Human Fibroblast growth factor 20(FGF20) ELISA kit

  • 中文名称：
    人成纤维细胞生长因子20(FGF20)酶联免疫试剂盒
  • 货号：
    CSB-EL008626HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    The product CSB-EL008626HU is a sandwich ELISA kit developed to measure levels of human FGF20 in multiple samples, including serum, plasma, cell lysates, or tissue homogenates. The enzyme-substrate chromogenic reaction is also used to amplify the signal and quantify the levels of the analyte through the intensity of the colored product. The color intensity positively correlates with the amount of FGF20 bound in the initial step.

    FGF20-FGFR1 signaling is essential for cochlear hair cell (HC) and supporting cell (SC) differentiation. FGF20 is expressed in hair placodes and is induced by and functions downstream from epithelial ectodysplasin (Eda)/Edar and Wnt/β-Catenin signaling to initiate the formation of the underlying dermal condensation. It controls the formation of primary and secondary dermal condensations in developing hair follicles and subsequent formation of guard, awl, and Duchene's hairs.

  • 别名：
    FGF-20 ELISA Kit; Fgf20 ELISA Kit; FGF20_HUMAN ELISA Kit; FGFK ELISA Kit; Fibroblast growth factor 20 ELISA Kit; RHDA2 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates, cell lysates
  • 检测范围：
    12.5 pg/mL-800 pg/mL
  • 灵敏度：
    3.12 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Neurotrophic factor that regulates central nervous development and function.
  • 基因功能参考文献：
    1. Studied effect of recombinant human fibroblast growth factor 20 (rhFGF20) on cultured mouse vibrissal follicles; found rhFGF20 significantly induced growth of the follicles in vitro, stimulated proliferation of hair matrix cells, and activated Wnt signal pathway. PMID: 29713847
    2. This study confirmed that the A allele of rs591323 in FGF20 reduces the risk of developing sporadic PD (P = 0.013). Additionally, subjects with the AA + AG genotype have a reduced risk compared to individuals with the GG genotype (P = 0.024). PMID: 28238162
    3. the FGF20 gene might not play a dominating role in the genetic predisposition to essential tremor in Chinese Han population. PMID: 27040428
    4. Meta-analysis indicated that the rs12720208 polymorphism may be associated with the Parkinson's disease susceptibility in Caucasians PMID: 28191856
    5. This study suggested that there is no sufficient evidence to support the association between FGF20 rs12720208 polymorphism and Parkinson's disease risk. PMID: 27023076
    6. The results of this study indicated that rs12720208 may contribute to the risk of PD in Iranian population. PMID: 26070653
    7. Meta-analysis suggests that FGF20 rs1721100 C/G polymorphism is associated with sporadic sporadic Parkinson's diseases in Asians PMID: 25030126
    8. The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model. PMID: 24942208
    9. The results showed no significant differences in the presence of rs1721100 or rs12720208 in the FGF20 gene between Parkinson's disease patients and controls. PMID: 23938014
    10. The results have not shown any effect of rs12720208 in the FGF20 gene on the risk of Parkinson's disease in patients residing in Russia PMID: 23516905
    11. This study revealed that the rs1721100(C/G) polymorphism is a risk factor for PD in Han Chinese population, while rs12720208(C/T) polymorphism is not significantly associated with Parkinson's disease. PMID: 22342445
    12. The data suggested that Fgf9/20 and Bmp7 organize the nephron progenitor niche and highlight the essential role of FGF20 in human kidney development. FGF signaling likely regulates multiple important steps in the stem cell niche. PMID: 22698282
    13. The common FGF20 rs12720208 SNP was not associated with the risk for Parkinson's disease (PD) in our population. In addition, we did not find nucleotide changes in miR-433 (that binds to the 3' UTR FGF20 mRNA) among our PD patients. PMID: 20471450
    14. The associations described, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging. PMID: 20427658
    15. Fibroblast growth factor 20 polymorphisms and haplotypes is associated with the risk of Parkinson disease PMID: 15122513
    16. Data show that FGF20 and DKK1 appear to be direct targets for beta-catenin/TCF transcriptional regulation via LEF/TCF-binding sites, and are expressed early in Xenopus embryogenesis under the control of the Wnt signaling pathway PMID: 15592430
    17. results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population PMID: 17515805
    18. Variants in FGF20 and MAOB show evidence of statistical interactions and potential patterns of biological interaction contributing to Parkinson disease risk. PMID: 18205889
    19. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. PMID: 18252210
    20. FGF20 is associated with Parkinson's disease synergistically with SNCA. PMID: 18568448
    21. Data demonstrate that homodimerization autoregulates FGF9 and FGF20's receptor binding and concentration gradients in the extracellular matrix. PMID: 19564416
    22. The effect of arginine on the solubility and stability of FGF-20 was dominated by the preferential binding interaction. PMID: 19619121
    23. FGF20, FGF9, and FGF16 constitute a subfamily among FGFs. FGF20 is preferentially expressed in colorectal cancer. PMID: 10913340

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  • 相关疾病：
    Renal hypodysplasia/aplasia 2 (RHDA2)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 组织特异性：
    Predominantly expressed in the cerebellum.
  • 数据库链接：

    HGNC: 3677

    OMIM: 605558

    KEGG: hsa:26281

    STRING: 9606.ENSP00000180166

    UniGene: Hs.199905