Human Fibrinogen beta chain (FGB) ELISA kit

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

1. High fibrinogen expression is associated with esophageal carcinoma. PMID: 29134563
2. Compared with the patients with TT genotypes of fibrinogen beta, expressions of fibrinogen, IL-6 and CRP were significantly higher in the patients with the CC and CT genotypes. PMID: 29165755
3. Two novel fibrinogen Bbeta chain mutations in two Slovak families with hypofibrinogenemia/afibrinogenemia have been described. PMID: 29286337
4. FGB c.490G>A indicated the activation of a cryptic splice site causing the insertion of 99 bp in intron 3. This splicing abnormality led to the production of a Bbeta-chain possessing 33 aberrant amino acids, including two Cys residues in the coiled-coil domain. Therefore, a splicing abnormality may cause impaired fibrinogen assembly and secretion. PMID: 29156616
5. FGB mutations leading to congenital hypofibrinogenaemia PMID: 28306188
6. Fibrinogen Bbeta448Lys variant is associated with thrombotic fibrin clots in type 2 diabetic patients independently of traditional risk factors. PMID: 27929198
7. There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors PMID: 27834463
8. elevated levels of plasma homocysteine /homocysteine thiolactone contribute to AD pathology via the Abeta-fibrin(ogen) interaction PMID: 27090576
9. procoagulant changes in fibrin metastructure appear to result from excessive carbonylation of fibrinogen, which may compensate for a decrease in fibrinogen level in patients with cirrhosis PMID: 26833718
10. Prognostic impact of plasma fibrinogen levels in patients with esophageal squamous cell carcinoma PMID: 28064398
11. a tight cluster of alternating multiple splicing regulatory elements and U1 snRNA binding sites controls cryptic splice donor usage throughout the human fibrinogen Bbeta-chain gene (FGB) exon 7 PMID: 28039323
12. The plasma fibrinogen level was found to be a possible biomarker for clinical response to chemotherapy and postoperative metastasis or death in advanced breast cancer patients who received neoadjuvant chemotherapy PMID: 28621233
13. Data suggest that, in the binding of fibrin beta N-domains and the (1-8) peptide fragment of VLDLR (very low density lipoprotein receptor), the second and third Lys/Arg clusters in fibrin make major contributions to this interaction while the contribution of the first cluster is moderate. PMID: 28437098
14. The novel missense mutation in the FGB gene causes afibrinogenemia most probably by affecting the secretion of the fibrinogen beta-chain. PMID: 27824214
15. fibrinogen aggregation is accompanied by the formation of beta-sheet conformation, and induction of non-native helical segments in the protein inhibits aggregation PMID: 27150313
16. fibrinogen is an independent predictor of the angiographic presence of coronary artery disease in hypertensive patients. PMID: 27553289
17. novel mutation was identified in exon 2 of FGB caused by c.221G> T (dagger) substitution PMID: 27812779
18. Our results show that higher levels of circulating chemerin, CRP, fibrinogen, and ESR are associated with an increased risk of developing colorectal cancer PMID: 26628300
19. We assessed the diagnostic accuracy of a newly developed laboratory score-based on CA125, platelet count (PLT), C-reactive protein (CRP), and fibrinogen levels-in the preoperative diagnosis of adnexal mass PMID: 26499778
20. the mechanical properties of individual fibrin fibers formed from blood plasma, were examined. PMID: 27028649
21. Here we report a new B[beta] gene mutation (Fibrinogen St Kilda) identified in two Caucasian sisters with reduced fibrinogen level (1.2-1.6 g/L) during investigation for recurrent early miscarriages. PMID: 26308135
22. desAB fibrin binds to prothrombin through the Bbeta26-42 amino acid residues and the formation of such a complex causes a non-enzymatic activation of prothrombin PMID: 26317125
23. Strong positive association has been found between betatrophin, plasma fibrinogen (FBG), and insulin resistance in non-diabetic subjects. Correlations with FBG and insulin resistance were diminished in type 2 diabetes subjects. PMID: 26077345
24. These experiments demonstrate, for the FGB-p.Asp185Asn mutation, a pathogenic mechanism not common for fibrinogen deficiencies, i.e. the hyperglycosylation of the Bbeta chain due to the introduction of a novel N-glycosylation motif. PMID: 26006300
25. High plasma fibrinogen levels and platelet count are associated with esophageal squamous cell carcinoma. PMID: 25896470
26. Results suggest that FGB -148 C/T and -854 G/A polymorphisms probably contribute to susceptibility of ischemic stroke in Chinese population. PMID: 25890854
27. The results of the meta-analysis indicate that the -455 G>A polymorphism in the beta-fibrinogen gene is a susceptibility marker of ischemic cerebral infarction in the Chinese population. PMID: 25398500
28. In the present study, we found that the -148C>T polymorphism in the FGB gene was significantly associated with ischemic stroke in a Chinese population [meta-analysis] PMID: 25867317
29. This prospective study in 110 patients undergoing major cardiovascular surgery at risk of post-cardiopulmonary bypass bleeding compares fibrinogen level. PMID: 26011420
30. the NGR motif in fibrinogen is the site that is primarily responsible for the interaction with resting alphaIIbbeta3 and is responsible for triggering platelet activation PMID: 25413489
31. Elevated fibrinogen levels are associated with negative tumor response to therapy in rectal cancer. PMID: 25384698
32. Four novel FGB mutations were identified in two afibrinogenemic (one new-born and one 30 years old male) and hypofibrinogenemic (a 49 years old female) patient, with heterogeneous thrombotic and bleeding phenotype PMID: 24560896
33. plasma fibrinogen increase during ischemic stroke has a role in worse outcome PMID: 24531853
34. meta-analysis suggests that the FGB-455G/A polymorphism contributes to susceptibility to ischemic stroke and coronary heart disease PMID: 24448059
35. results of our meta-analysis suggested that the-148C>T polymorphism in the FGB gene is a susceptibility marker of ischemic stroke PMID: 24720800
36. The A + genotype of the FGB -455 G/A polymorphism associated with poor survival among 55-71 years old Caucasian women in the Finnish stroke cohort. PMID: 24957141
37. results indicate that FGbeta-455G/A polymorphism may be a susceptible predictor of ischemic stroke [meta-analysis] PMID: 24366241
38. Elevated fibrinogen is associated with idiopathic sudden hearing loss. PMID: 24466284
39. High fibrinogen levels are associated with gynecologic cancer. PMID: 25204086
40. Both fibrinogen polymorphisms are capable to modify the atherosclerotic process via their effects on the coagulation cascade. PMID: 23931975
41. The beta-fibrinogen -455G/A gene polymorphism is not a risk factor for ischaemic stroke in a Polish population. PMID: 23650004
42. A meta-analysis of a Chinese population found that the FgB -455G/A and the -148C/T gene polymorphism was implied to be associated with coronary artery disease susceptibility. PMID: 23129316
43. Both isoforms of the beta-chain of FIB discovered by 2D-gel electrophoresis are decreased in the Parkinson's disease group cerebrospinal fluid, compared to normal controls. PMID: 22889670
44. Lys, as an inhibitor of protein glycation, improved fibrinogen's structure and function, both in vitro and in vivo. PMID: 22575419
45. Fibrinogen polymorphisms contributes to the association between common variants in the fibrinogen gene and the risk of developing sporadic cerebral hemorrhage. PMID: 22386478
46. study found that -C148T FGB polymorphism was an independent predictor of pre- and early postoperative C-reactive protein levels in coronary artery bypass graft patients PMID: 21499712
47. genetic polymorphism is associated with plasma fibrinogen levels and haematological traits in whites, blacks and mexican americans PMID: 22273812
48. Levels of fibrinogen and thromboelastometry fibrin polymerisation following treatment with desmopressin (DDAVP). PMID: 22293628
49. The BF -455G/A polymorphisms was found to be positively. PMID: 21241403
50. Fibrinogen has chaperone activity which is compromised upon glycation by methylglyoxal. PMID: 22053176

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Congenital afibrinogenemia (CAFBN); Dysfibrinogenemia, congenital (DYSFIBRIN)

Secreted.

Detected in blood plasma (at protein level).

HGNC: 3662

OMIM: 134830

KEGG: hsa:2244

STRING: 9606.ENSP00000306099

UniGene: Hs.300774