Human Corin ELISA Kit

Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing. Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney.; has weaker endopeptidase activity compared to isoform 1.

1. Data suggest that soluble corin lacking transmembrane domain is activated by PCSK6 in conditioned medium or in cell-free system but not intracellularly; cell membrane association is unnecessary for PCSK6 to activate corin; soluble corin and PCSK6 are secreted by cardiomyocytes (or HEK293 cells) via different intracellular pathways. (PCSK6 = proprotein convertase subtilisin/kexin type-6) PMID: 29180304
2. Suggest that pro-ANP/corin/NPR-C signaling is dominant in the vascular system in preeclampsia. PMID: 29523263
3. These results indicate that genetic variants impairing corin function are not uncommon in general populations and that such variants may be an important contributing factor in hypertension. PMID: 28861913
4. Preeclampsia is one of the most severe complications of the pregnancy, and trials to estimate a panel of predictive markers are of big interest for multiple researches. Corin is a transmembrane serine protease, localized in the heart, which is converting pro-ANP in to active ANR. ANP is a hormone regulating salt hemostasis and arterial blood pressure. [review] PMID: 29370493
5. Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease. PMID: 27898523
6. association of 2 single nucleotide polymorphisms in CORIN (rs2271037 and rs3749585) with hypertension, as well as their potential interactions with some risk factors of hypertension in a Han population of northeastern China PMID: 29391274
7. We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension. PMID: 27871468
8. Corin and atrial natriuretic peptide A were most abundant in the proximal convoluted tubules and the medullary connecting ducts. PMID: 27343265
9. CORIN expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
10. serum levels of corin are significantly decreased in acute myocardial infarction patients PMID: 26577631
11. Data show that both furin and brain type natriuretic peptide (BNP) were more sensitive than corin in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients. PMID: 26488448
12. Circulating corin concentrations are related to infarct size in patients after ST-segment elevation myocardial infarction PMID: 25981578
13. Hypertensive participants had an increased serum corin level compared to those without hypertension, suggesting that corin may play a role in the pathology of hypertension. PMID: 25663063
14. Serum soluble corin was significantly and positively associated with dyslipidemia PMID: 26344336
15. Plasma corin levels decreased significantly from preoperative concentrations after coronary artery bypass graft surgery. PMID: 25649697
16. corin may play an important role in the pathology of atrial fibrillation PMID: 26048191
17. Increased serum soluble corin in mid pregnancy was associated with an increased risk for HDP(hypertensive disorders of pregnancy) .--increased serum soluble corin in mid pregnancy could be an indicator for HDP PMID: 26086065
18. identified a PCSK6 mutation that impaired corin activation activity in a hypertensive patient PMID: 26259032
19. the variant altered corin structure and impaired the natriuretic peptide processing activity in vivo. The results highlight corin defects as an important underlying mechanism in hypertension. PMID: 25488193
20. IRE1-dependent corin mRNA decay is a mechanism leading to corin protein deficiency may contribute to the pathophysiology of impaired natriuretic peptide pro-hormone processing in humans processing in humans with advanced systolic heart failure. PMID: 25516437
21. Serum soluble corin was decreased in patients with stroke compared with healthy controls. PMID: 26022632
22. In conclusion, this is the first report of a highly significant association between these two single nucleotide polymorphisms in CORIN gene and preeclampsia. PMID: 25474356
23. N-glycans at different sites may play distinct roles in regulating the cell membrane targeting, zymogen activation, and ectodomain shedding of corin PMID: 25451932
24. data provide important insights into the molecular basis underlying corin mutations that may contribute to preeclampsia in patients. PMID: 24828501
25. Corin mediates an essential step in the cascade of natriuretic peptide biosynthesis and eventually their action. Thus, it is postulated that aberrations in the normal activity of corin may contribute to cardiovascular and renal diseases. PMID: 24100222
26. CORIN is expressed in non-pregnant late secretory phase endometrium, first trimester human implantation sites and is up-regulated with decidualization ex vivo PMID: 23434834
27. The processing of proBNP1_108 by corin may be controlled by O-linked glycosylation of proBNP1-108. A potential impairment of proBNP1lo8 processing in heart failure may be linked to dysregulation of the convertase corin.[Review] PMID: 24015598
28. human CORIN gene mutations causing impaired corin activity may be an underlying mechanism in hypertension PMID: 23372161
29. The results indicate that renal tubular corin may be shed into urine and that urinary and renal corin levels were reduced in chronic kidney disease patients. PMID: 23327554
30. Results indicate that corin defects may represent an important mechanism in salt-sensitive hypertension and cardiac hypertrophy in blacks. PMID: 22987923
31. results indicate that corin and ANP are essential for physiological changes at the maternal-fetal interface, suggesting that defects in corin and ANP function may contribute to pre-eclampsia PMID: 22437503
32. the function and regulation of corin PMID: 22093942
33. the sequence in the cytoplasmic tail plays an important role in corin cell surface targeting and zymogen activation. PMID: 21518754
34. Ectodomain shedding and autocleavage of the cardiac membrane protease corin. PMID: 21288900
35. Data suggest that there may be patients for whom low corin levels and impaired pro-ANP cleavage contribute to acute decompensated heart failure. PMID: 21216831
36. A modest correlation is demonstrated between plasma corin levels and individual echocardiographic indices of cardiac hypertrophy, but no relationships between plasma corin and myocardial performance are proved in this study. PMID: 20670840
37. corin might be involved in the salt retention seen in glomerular diseases. PMID: 20613715
38. Insufficient corin activation is expected to prevent natriuretic peptide processing and may contribute to body fluid retention and impaired cardiac function in patients with heart failure. PMID: 20802129
39. Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes. PMID: 11884416
40. These data indicate that the GATA element and its binding to GATA-4 are essential for cardiac expression of the human and murine corin genes. PMID: 12154094
41. the transmembrane domain is not necessary for the biological activity of corin but may be a mechanism to localize corin at specific sites PMID: 14559895
42. in CORIN, the frizzled 1 domain and LDLR repeats 1-4 are important structural elements for recognition of the physiological substrate, pro-ANP PMID: 15192093
43. The corin I555 (P568) allele is common in blacks and is associated with higher blood pressure and an increased risk for prevalent hypertension. PMID: 16216958
44. Corin I555(P568) allele represents a cardiac hypertrophy-sensitizing genetic locus in systemic hypertension. PMID: 17296875
45. N-linked oligosaccharides play an important role in corin activation PMID: 17660514
46. ANP and corin are expressed at the mRNA level in human adipose tissue and preadipocytes PMID: 17890485
47. corin gene single nucleotide polymorphism associated with hypertension and cardiac hypertrophy impair corin zymogen activation and natriuretic peptide processing activity PMID: 18669922
48. Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy. PMID: 19919978

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Pre-eclampsia/eclampsia 5 (PEE5)

Cell membrane; Single-pass type II membrane protein. Note=May easily detached from the endothelial cell membrane.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.; [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Note=Soluble form produced following cleavage by ADAM10.; [Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.; [Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.

Peptidase S1 family

Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).

HGNC: 19012

OMIM: 605236

KEGG: hsa:10699

STRING: 9606.ENSP00000273857

UniGene: Hs.518618