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  4. Human Complement C2(C2) ELISA kit

Human Complement C2(C2) ELISA kit

  • 中文名称：
    人补体C2(C2)酶联免疫试剂盒
  • 货号：
    CSB-EL003658HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        C2是补体系统中的一个组分，属于C1s-C4s酶激活的中间物。C2的主要作用是与C3b和C4b形成C3和C5转化酶，促进补体系统的激活。C2缺乏会导致免疫系统缺陷和易感染病情。C2在肝脏中合成，通过循环系统输送到其他组织。
        j9九游会登录入口首页生物所提供的Human Complement C2(C2) ELISA kit属于ELISA检测试剂盒，采用竞争法定量检测人血清、血浆、组织匀浆样本中的C2，其灵敏度为15.6 ng/mL，检测范围为15.6 ng/mL-250 ng/mL。
     
  • 别名：
    ARMD14 ELISA Kit; C2 ELISA Kit; C3/C5 convertase ELISA Kit; CO2 ELISA Kit; CO2_HUMAN ELISA Kit; Complement C2 ELISA Kit; Complement C2a fragment ELISA Kit; complement component 2 ELISA Kit; DKFZp779M0311 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    15.6 ng/mL-250 ng/mL
  • 灵敏度：
    15.6 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Competitive
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
        C2，又称为补体蛋白C2（Complement component 2），是人体中重要的补体系统蛋白之一，与C1、C4等其他补体成分一起作为免疫系统的一部分发挥作用。C2可与其他补体成分相互作用，形成补体复合物，引发一系列补体级联反应，最终导致病原体破坏和溶解。C2的缺失可导致免疫系统功能异常，易发生感染和自身免疫疾病。近年来的研究表明，C2的基因多态性与许多疾病（如自身免疫性疾病、心血管疾病、肝脏疾病等）的风险相关，成为了许多疾病的潜在标志物。
     
  • 功能：
    Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
  • 基因功能参考文献：
    1. Vag8 binding to human C1-inhibitor (C1-inh) interferes with the binding of C1-inh to C1s, C1r and MASP-2, resulting in the release of active proteases that subsequently cleave C2 and C4 away from the bacterial surface. PMID: 28742139
    2. Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases. PMID: 27252379
    3. The rs2844455 A allele of C2 is a risk factor for systemic lupus erythematosus development in a Chinese population, whereas the G allele might be a protective factor. PMID: 26176736
    4. our data indicate that C2 rs547154 polymorphism plays a protective role in the development of PCV. PMID: 25732348
    5. Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. PMID: 24983375
    6. These overall results suggest a lack of strong association with the C2 and C7 gene polymorphisms to the susceptibility of systemic lupus erythematosus in the Malaysian population. PMID: 21881993
    7. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
    8. CFH (RS1061170), C2 (RS547154), OR CFB (RS438999) was not associated with early or late AMD. PMID: 23060141
    9. These data suggest that patients with C2 deficiency are at increased risk of Streptococcus pyogenes infections. PMID: 20417301
    10. C2 microheterogeneity and histocompatibility antigens Class I were studied in an Austrian population. PMID: 12823772
    11. study of the formation of high affinity C5 convertase of the classical pathway of complement PMID: 12878586
    12. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2 PMID: 16670774
    13. a weaker, independent protective effect exists for complement component 2 in age related macular degeneration. PMID: 17576744
    14. These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections. PMID: 18541650
    15. Study provides insights into the genetic pathogenesis of AMD, and C2 has been shown as one of the five genes independently involved in progression from intermediate disease to advanced disease in which blindness is frequent. PMID: 19015224
    16. Upon cleavage by C1s, C2a domains undergo conformational rotation while bound to C4b and the released C2b domains may remain folded together as seen in the intact protein. PMID: 19237749

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  • 相关疾病：
    Complement component 2 deficiency (C2D)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 数据库链接：

    HGNC: 1248

    OMIM: 217000

    KEGG: hsa:717

    STRING: 9606.ENSP00000299367

    UniGene: Hs.408903