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  4. Human Collectrin(TMEM27) ELISA kit

Human Collectrin(TMEM27) ELISA kit

  • 中文名称：
    人Collectrin蛋白/跨膜蛋白27(TMEM27)酶联免疫试剂盒
  • 货号：
    CSB-EL023823HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human TMEM27 ELISA Kit was designed for the quantitative measurement of Human TMEM27 protein in serum, plasma,tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 56 pg/mL-800 pg/mL and the sensitivity is 24 pg/mL.

  • 别名：
    UNQ679 ELISA Kit; Collectrin ELISA Kit; kidney-specific membrane protein ELISA Kit; NX-17 ELISA Kit; NX17 ELISA Kit; PRO1312 ELISA Kit; Tmem27 ELISA Kit; TMM27_HUMAN ELISA Kit; Transmembrane protein 27 ELISA Kit; UNQ679/PRO1312 ELISA Kit
  • 缩写：
    TMEM27
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma,tissue homogenates, cell lysates
  • 检测范围：
    56 pg/mL-800 pg/mL
  • 灵敏度：
    24 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Metabolism
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
  • 基因功能参考文献：
    1. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. PMID: 28764560
    2. Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. PMID: 27417314
    3. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. PMID: 24693993
    4. Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. PMID: 21907142
    5. Tmem27 dimerization is a dynamic process involving Bace2 PMID: 22628310
    6. Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
    7. Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. PMID: 20386877
    8. Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
    9. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. PMID: 19417552
    10. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease PMID: 19582483

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TMEM27 family
  • 组织特异性：
    Kidney; collecting ducts. Pancreas; beta cells of islets.
  • 数据库链接：

    HGNC: 29437

    OMIM: 300631

    KEGG: hsa:57393

    STRING: 9606.ENSP00000369699

    UniGene: Hs.129614