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  4. Human Cardiotrophin-like cytokine factor 1(CLCF1) ELISA kit

Human Cardiotrophin-like cytokine factor 1(CLCF1) ELISA kit

  • 中文名称：
    人心脏营养素样细胞因子1(CLCF1)酶联免疫试剂盒
  • 货号：
    CSB-EL005479HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human CLCF1 ELISA Kit was designed for the quantitative measurement of Human CLCF1 protein in serum, plasma, cell culture supernates, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.312 ng/mL-20 ng/mL and the sensitivity is 0.078 ng/mL.

  • 别名：
    B cell stimulating factor 3 ELISA Kit; B-cell-stimulating factor 3 ELISA Kit; BSF 3 ELISA Kit; BSF-3 ELISA Kit; BSF3 ELISA Kit; Cardiotrophin like cytokine ELISA Kit; Cardiotrophin like cytokine factor 1 ELISA Kit; Cardiotrophin-like cytokine factor 1 ELISA Kit; CISS 2 ELISA Kit; CISS2 ELISA Kit; CLC ELISA Kit; CLCF 1 ELISA Kit; Clcf1 ELISA Kit; CLCF1_HUMAN ELISA Kit; Cold induced sweating syndrome 2 ELISA Kit; CRLF 1 associated cytokine like factor 1 ELISA Kit; CRLF1 associated cytokine like factor 1 ELISA Kit; Neurotrophin 1 ELISA Kit; Neurotrophin 1/B cell stimulating factor 3 ELISA Kit; Neurotrophin1 ELISA Kit; NNT 1 ELISA Kit; NNT-1 ELISA Kit; Novel neurotrophin 1 ELISA Kit; Novel neurotrophin-1 ELISA Kit; NR 6 ELISA Kit; NR6 ELISA Kit
  • 缩写：
    CLCF1
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 检测范围：
    0.312 ng/mL-20 ng/mL
  • 灵敏度：
    0.078 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Others
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
  • 基因功能参考文献：
    1. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
    2. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
    3. albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
    4. activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
    5. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
    6. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012

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  • 相关疾病：
    Cold-induced sweating syndrome 2 (CISS2)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-6 superfamily
  • 组织特异性：
    Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
  • 数据库链接：

    HGNC: 17412

    OMIM: 607672

    KEGG: hsa:23529

    STRING: 9606.ENSP00000309338

    UniGene: Hs.502977