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  4. Human C-C motif chemokine 7 (CCL7/MCP3/SCYA6/SCYA7) ELISA kit

Human C-C motif chemokine 7 (CCL7/MCP3/SCYA6/SCYA7) ELISA kit

  • 中文名称：
    人CC趋化因子7 (CCL7/MCP3/SCYA6/SCYA7)酶联免疫试剂盒
  • 货号：
    CSB-E17377h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    The product CSB-E17377h is a sandwich ELISA kit developed to measure concentrations of human CCL7 in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of CCL7 in samples. The color intensity is measured at 450 nm via a microplate reader.

    CCL7 is a potent chemoattractant for various leukocytes, including monocytes, eosinophils, basophils, dendritic cells (DCs), NK cells, and activated T lymphocytes. As a chemotactic factor, CCL7 recruits a leukocyte subtype to infected tissues to address pathologic invasion and fine-tune the immune response by binding to its receptors including CCR1, CCR2, CCR3, CCR5, and CCR10. CCL7 plays an important role in various pathologies, including cancers, auto-immune diseases, and chronic inflammation. It promotes tumor progression by supporting the formation of the tumor microenvironment and facilitating tumor invasion and metastasis.

  • 别名：
    C-C motif chemokine 7 ELISA Kit; Ccl7 ELISA Kit; CCL7_HUMAN ELISA Kit; Chemokine CC motif ligand 7 ELISA Kit; FIC ELISA Kit; MARC ELISA Kit; MCP-3 ELISA Kit; Monocyte chemoattractant protein 3 ELISA Kit; Monocyte chemotactic protein 3 ELISA Kit; NC28 ELISA Kit; RP23-350G1.4 ELISA Kit; SCYA6 ELISA Kit; SCYA7 ELISA Kit; Small-inducible cytokine A7 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma,tissue homogenates
  • 检测范围：
    15.6 pg/mL-1000 pg/mL
  • 灵敏度：
    3.9 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
  • 基因功能参考文献：
    1. Enzyme-linked immunosorbent assay was used to detect the levels of chemokine (C-X-C motif) ligand 12, chemokine (C-X-C motif) ligand 7, hepatocyte growth factor, and fibroblast growth factor 1 in the supernatants of the laryngeal squamous cell carcinoma and control cells. PMID: 28475003
    2. Periprostatic adipocytes drive prostate cancer progression in obesity via CCL7 secretion which stimulates CCR3 expressing tumor cells. PMID: 26756352
    3. These results suggest that let-7d may suppress renal cell carcinoma growth, metastasis, and tumor macrophage infiltration at least partially through targeting COL3A1 and CCL7. PMID: 25193015
    4. Based on nasopharyngeal CCL7 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants. PMID: 25261323
    5. Overexpression of ISL1 in human mesnchymal stem cells promotes angiogenesis in vitro and in vivo through increasing secretion of MCP3 and other paracrine factors. PMID: 24578274
    6. Our data demonstrate that the monocyte-specific chemokine CCL7 and its receptor CCR2 are expressed in tumour cells of RCC PMID: 24327013
    7. Systemic IFN-gamma triggered the secretion of C-C motif ligand chemokines CCL2 and CCL7 leading to the egress of early, myeloid-committed progenitors from the bone marrow mediated by their common receptor CCR2. PMID: 23762028
    8. Anticancer effect of desmethyl-lasiodiplodin is mediated, in part, by upregulation of apoptotic genes and downregulation of MCP-3. PMID: 23764760
    9. Immunohistochemistry and real-time PCR analysis showed that CCL7 was expressed in normal colonic epithelium and the expression was higher in liver metastases compared to primary CRC. PMID: 22614322
    10. These results suggest that overexpression of CCL21 and CCL7 is associated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer. PMID: 22468089
    11. MCP-3 is produced by human coronary artery smooth muscle cells and directly induces CASMC proliferation in vitro, suggesting a potential role for this chemokine in vascular pathology PMID: 21536288
    12. we established, for the first time, a significant association of MCP3 variants with atopic asthma. PMID: 21388664
    13. Basal monocyte migration may be facilitated by the astrocyte-derived cytokine CCL7 whose production is rapidly increased by TNF-alpha and thus likely plays a critical role in initiating neuroinvasion by SIV/HIV. PMID: 21279498
    14. The expression of MCP-3 in laryngeal squamous cell carcinoma is much higher than in normal tissue. PMID: 18533557
    15. IL-12 p35, ICAM-1 and MCP-3 mRNAs are expressed in primary nasal epithelial cells. PMID: 19253530
    16. Cytoplasmic GR interacts with a subset of CCL7 mRNA through specific sequences and can regulate turnover rates, a novel posttranscriptional role for GR as an RNA-binding protein. PMID: 21148795
    17. Monocyte chemoattractant protein-3 (MCP-3) was highly expressed in patients with chronic periodontitis, particularly in those with progressive periodontal lesions. PMID: 20151806
    18. higher expression in the genital mucosa than in the blood of HIV-1-infected women from Benin PMID: 19898927
    19. Elevated level of CCL7 is associated with invasion and migration of oral squamous cell carcinoma. PMID: 19937793
    20. The two most abundant alleles of the CA/GA microsatellite polymorphism in the promoter-enhancer region of the MCP-3 gene, A2 and A3, are significantly associated with multiple sclerosis in the Belgian case-control study, but not in the family study. PMID: 12127674
    21. overexpression of MCP-3 in early-stage systemic sclerosis suggests a novel role for this protein as a fibrotic mediator activating extracellular matrix gene expression in addition to promoting leukocyte trafficking. PMID: 12847692
    22. monocyte chemotactic protein-3 uses a different mode of action from eotaxin PMID: 14733956
    23. data suggest that cyclic mechanical stretch of the uterine cervix by the presenting part of the fetus during labour may augment both IL-8 and MCP-3 production in the uterine cervix via AP-1 activation. PMID: 15194816
    24. These results suggest that oxLDL delivers its signal for MCP-3 expression via PPARgamma, which may be further related to the atherogenesis. PMID: 15381085
    25. A non-heparin-binding mutant CCL7 inhibits chemotactic potential of synovial fluid from patients with active rheumatoid arthritis and demonstrates the glycosaminoglycan-binding requirement for chemokine-driven inflammation in vivo PMID: 16002730
    26. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
    27. MCP-3 is critical for monocyte mobilization and suggests new roles for monocyte chemoattractants in leukocyte homeostasis. PMID: 17364026
    28. CCL7 synergizes with coproduced CXCL8 in peripheral blood monocyte migration. PMID: 18469140
    29. increased plasma levels in patients with amnestic mild cognitive impairment PMID: 19403065
    30. High MCP-3 is associated with macrophage/microglia infiltration in gliomas. PMID: 19424580

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 数据库链接：

    HGNC: 10634

    OMIM: 158106

    KEGG: hsa:6354

    STRING: 9606.ENSP00000367832

    UniGene: Hs.251526