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  4. Human C-C motif chemokine 14(CCL14) ELISA kit

Human C-C motif chemokine 14(CCL14) ELISA kit

  • 中文名称：
    人CC趋化因子14(CCL14)酶联免疫试剂盒
  • 货号：
    CSB-EL004777HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This human CCL14 ELISA kit employs the quantitative sandwich enzyme immunoassay technique to measure the levels of human CCL14 in multiple samples, including serum, plasma, or tissue homogenates. It also uses the enzyme-substrate chromogenic reaction to visualize and analyze the analyte levels through the color intensity. The intensity of the colored product is in direct proportion to the CCL14 levels in the sample and is measured at 450 nm through a microplate reader.

    CCL14, also known as HCC-1, is found in high concentrations in blood plasma and acts as an inflammatory chemokine after N-terminus cleavage. It promotes the chemotaxis of monocytes, eosinophils, and T lymphoblasts. CCL14 specifically binds to CCR1, CCR3, and CCR5 to exert biological effects. CCL14 plays a dual role in the occurrence and development of cancer. A study showed that CCL14 inhibited the proliferation and invasion of colon cancer cells by impeding the formation of M2-like tumor-associated macrophages (TAMs). CCL14 was downregulated in several human cancers, including hepatocellular carcinoma (HCC). CCL14 expression in HCC tissues correlated with prognosis. Low CCL14 expression is linked to poorer overall survival, disease-specific survival, progression-free survival, and relapse-free survival in multiple cohorts of HCC patients, particularly at early disease stages.

  • 别名：
    CC-1 ELISA Kit; CC-3 ELISA Kit; CCL14 ELISA Kit; CCL14_HUMAN ELISA Kit; chemokine (C-C motif) ligand 14 ELISA Kit; Chemokine CC-1/CC-3 ELISA Kit; chemokine CC1 ELISA Kit; chemokine CC3 ELISA Kit; chemokine HCC1 ELISA Kit; chemokine HCC3 ELISA Kit; CKb1 ELISA Kit; HCC 1 ELISA Kit; HCC 3 ELISA Kit; HCC-1(1-74) ELISA Kit; HCC-1(9-74) ELISA Kit; HCC-1/HCC-3 ELISA Kit; HCC-3 ELISA Kit; HCC1 ELISA Kit; HEMOFILTRATE CC CHEMOKINE 1 ELISA Kit; MCIF ELISA Kit; NCC-2 ELISA Kit; NCC2 ELISA Kit; new CC chemokine 2 ELISA Kit; SCYA14 ELISA Kit; SCYL2 ELISA Kit; small inducible cytokine subfamily A (Cys-Cys); member 14 ELISA Kit; Small-inducible cytokine A14 ELISA Kit; SY14 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.156 ng/mL-10 ng/mL
  • 灵敏度：
    0.039 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
  • 基因功能参考文献：
    1. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
    2. CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer. PMID: 21937684
    3. enhanced expression in intestinal epithelium in inflammatory bowel disease and display of antibacterial activity PMID: 19812544
    4. Functional data from activity assays by intracellular calcium flux and inhibition of CCR5-mediated HIV-1 entry show that only CCL14 [9-74] is fully active at these near-physiological concentrations where CCL14 [9-74] is monomeric and CCL14 is dimeric PMID: 17691823
    5. CCL14 is involved in mechanisms by which trophoblast cells migrate during early pregnancy. PMID: 18367676
    6. SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype. PMID: 18602166
    7. the activity of CCL14a might be regulated by stringent proteolytic activation and inactivation steps PMID: 19553544
    8. D6 cooperates with CD26 in the negative regulation of CCL14 by the selective degradation of its biologically active isoform. PMID: 19632987

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
  • 数据库链接：

    HGNC: 10612

    OMIM: 601392

    KEGG: hsa:6358

    UniGene: Hs.272493