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Human Bone morphogenetic protein 8B(BMP8B) ELISA kit

  • 中文名称：
    人骨形态发生蛋白8B(BMP8B)酶联免疫试剂盒
  • 货号：
    CSB-EL002746HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human BMP8B ELISA Kit was designed for the quantitative measurement of Human BMP8B protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 9.37 pg/mL-600 pg/mL and the sensitivity is 2.34 pg/mL.

  • 别名：
    BMP-8 ELISA Kit; BMP-8B ELISA Kit; BMP8 ELISA Kit; Bmp8b ELISA Kit; BMP8B_HUMAN ELISA Kit; bone morphogenetic protein 8 (osteogenic protein 2) ELISA Kit; Bone morphogenetic protein 8 ELISA Kit; Bone morphogenetic protein 8B ELISA Kit; dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)) ELISA Kit; OP-2 ELISA Kit; OP2 ELISA Kit; Osteogenic protein 2 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    9.37 pg/mL-600 pg/mL
  • 灵敏度：
    2.34 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human BMP8B in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:5 Average % 94  
    Range % 90-98  
    1:10 Average % 88  
    Range % 82-94  
    1:20 Average % 103  
    Range % 99-108  
    1:40 Average % 95  
    Range % 90-100  
  • 回收率：
    The recovery of human BMP8B spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 96 92-100  
    EDTA plasma (n=4) 98 94-103  
                 
                 
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    600 2.056 2.205 2.131 2.008  
    300 1.607 1.724 1.666 1.543  
    150 1.102 1.075 1.089 0.966  
    75 0.645 0.603 0.624 0.501  
    37.5 0.394 0.373 0.384 0.261  
    18.75 0.291 0.302 0.297 0.174  
    9.37 0.187 0.201 0.194 0.071  
    0 0.120 0.125 0.123    
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
  • 基因功能参考文献：
    1. Acetylated H3K9 and H4K16 levels at BMP8B were increased in gastric cancer (GC) compared to nontumors (P < 0.05). However, reduced levels of acetylated H3K9 and H4K16 were associated with poorly differentiated GC (P < 0.05). PMID: 27748538
    2. Study found that BMP8B was downregulated in pancreatic cancer tissues and BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer. PMID: 25176058
    3. Five novel SNPs within BMP8B gene.Genetic variants in BMP8B gene are associated with growth traits in Chinese native cattle. PMID: 24076131
    4. Epigenetic silencing of the bone morphogenetic protein 2 gene through methylation is associated with gastric carcinomas PMID: 16314833
    5. Reports on the mouse homolog of this gene. PMID: 9070944

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 数据库链接：

    HGNC: 1075

    OMIM: 602284

    KEGG: hsa:656

    STRING: 9606.ENSP00000361915

    UniGene: Hs.734367