Human Baculoviral IAP repeat-containing protein 3(BIRC3) ELISA kit

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

1. High BIRC3 expression is associated with Oral squamous cell carcinoma. PMID: 29286141
2. Results indicate that Pellino-1 contributes to lung oncogenesis through the overexpression of inhibitor of apoptosis protein 2 (cIAP2) and promotion of cell survival and chemoresistance. PMID: 27248820
3. We show that BIRC3 has a unique role in facilitating glioma progression from low- to high-grade PMID: 27074575
4. CIAP2 expression was elevated in human GBC tissues. PMID: 28295868
5. destabilization of TRAF2 by miR-17 reduced the ability of TRAF2 to associate with cIAP2, resulting in the downregulation of TNF-alpha-induced NF-kappaBp65, c-Jun, and STAT3 nuclear translocation and the production of IL-6, IL-8, MMP-1, and MMP-13 in human rheumatoid arthritis synovial fibroblasts. PMID: 27534557
6. The expression of cIAP2 mRNA was significantly higher in the groups with Helicobacter pylori(+), atrophic gastritis/intestinal metaplasia(+), and Helicobacter pylori-positive early gastric cancer than in the control, Helicobacter pylori(+), and atrophic gastritis/intestinal metaplasia(-) groups. PMID: 27282269
7. Polymorphisms in the BIRC3 gene are associated with a protective effect with regards to asthma susceptibility, and a reduced load of inflammatory cells. PMID: 27304223
8. we indicated that miR-34a can inhibit tumor invasion and metastasis in osteosarcoma, and its mechanism may be partly related to downregulating the expression of C-IAP2 and Bcl-2 protein directly or indirectly. PMID: 28635396
9. Study demonstrate that BIRC3 expression increases secondary to acquisition of temozolomide TMZ and irradiation resistance in glioblastoma. PMID: 26888114
10. High BIRC3 expression is associated with pancreatic cancer. PMID: 26815504
11. Network analysis identified BIRC3 as pathogenic gene in childhood asthma. PMID: 27420950
12. The clinical impact of small subclones harboring NOTCH1, SF3B1, or BIRC3 mutations in chronic lymphocytic leukemia patients appears to be less pronounced than that of small TP53 mutated subclones. PMID: 26819056
13. cIAP2 is upregulated in regenerative epithelial cells both in ulcerative colitis and in experimental intestinal wounds. Inhibition of cIAP2 decreases wound healing in vitro possibly through inhibition of migration. [review] PMID: 26513451
14. LapR cells possessed increased levels of 2 of the inhibitors of apoptosis (IAPs), survivin and c-IAP-2, which are reported to block caspase activation downstream of cytosolic cytochrome C release. PMID: 25692408
15. API2-MALT1 induces paracaspase-mediated cleavage of the tumour suppressor protein LIMA1. PMID: 25569716
16. this study candidates BIRC3 as one of the potentially useful predictive marker for discriminating patients with oesophageal and oesophagogastric junction adenocarcinoma who will most likely benefit from preoperative chemoradiotherapy. PMID: 26291056
17. these results indicate that N. gonorrhoeae stimulation of human endocervical epithelial cells induces the release of cIAP2, an essential regulator of cell death and immune signaling. PMID: 26077759
18. Cytoplasmic expression of HuR is associated with cIAP2 expression in OSCCs PMID: 23852810
19. in 11q-deleted patients treated with first-line chemotherapy, ATM mutation rather than BIRC3 deletion and/or mutation identifies a subgroup with a poorer outcome. PMID: 24584352
20. a number of genes not previously known to be affected by RUNX2 expression, in particular BIRC3, genes encoded on the mitochondrial genome, and several genes involved in bone and tooth formation. PMID: 24349465
21. TNF-alpha induced apoptosis of gastric cancer cells via accelerated degradation of the inhibitor of apoptosis family members, CIAP2, XIAP, and survivin. PMID: 25513960
22. cIAP2 is in conclusion a regulator of human intestinal wound healing through enhanced migration along with activation of Rac1 PMID: 25394657
23. Data indicate that tumor necrosis factor inducible protein A20-mediated inhibitor of apoptosis protein-2 (cIAP-2) is important in endothelial cell resistance to tumor necrosis factor alpha (TNF-alpha)-induced apoptosis. PMID: 24595242
24. Identification and function of the NIK IAP binding motif, which promotes c-IAP1-dependent ubiquitylation of NIK. PMID: 25246529
25. Distinctive role of c-IAP2 as stabilizer of XIAP, which is likely involved in regulation of NFkappaB activation and apoptosis in GBM cells was determined. PMID: 24552816
26. increased expression with progression of chronic myeloid leukaemia PMID: 24266799
27. our study implicates RIP1 ubiquitination as a critical component of API2-MALT1-dependent lymphomagenesis PMID: 23770847
28. BIRC3 gene mutation is associated with chronic lymphocytic leukemia. PMID: 23558524
29. we present cIAP-2 as a novel inducer of platinum resistance in ovarian carcinoma cells, and suggest an axis beginning with an encounter between cisplatin and these cells, mediated sequentially by IL-6 and cIAP-2, resulting in cisplatin resistance PMID: 23052480
30. The expression of C-IAP2 in hepatocellular carcinoma is associated with tumor recurrence and metastasis. PMID: 22820591
31. Clonal evolution from lower to higher risk implicated the emergence of NOTCH1, SF3B1, and BIRC3 abnormalities in addition to TP53 and 11q22-q23 lesions in chronic lymphocytic leukemia. PMID: 23243274
32. A novel role for cIAP2 in maintaining wild-type p53 levels by preventing both an NFkappaB-mediated increase and IKKalpha/-beta-dependent transcriptional and post-translational modifications of MDM2. PMID: 23032264
33. study shows API2-MALT1 fusion oncoprotein induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK); resulting deregulated NIK activity is associated with constitutive noncanonical NF-kappaB signaling, enhanced B cell adhesion and apoptosis resistance PMID: 21273489
34. TRAF2 and cIAP2 are involved in TWEAK-induced MMP-9 production in fibroblast-like synoviocytes in rheumatoid arthritis. PMID: 21229359
35. NF-kappaappaB, acting through two response elements, is required for estrogen receptor recruitment to an adjacent estrogen response element in the BIRC3 promoter. PMID: 22083956
36. BIRC3 disruption is a common mechanism across marginal zone B-cell lymphomagenesis. PMID: 21881048
37. our results suggest that CpG-induced protection may be mediated by c-IAP-2 through the calcium-activated JNK pathway PMID: 22068233
38. cIAP2 may play an important role in Helicobacter pylori -induced gastric carcinogenesis PMID: 21963223
39. we confirm that mRNA and protein levels for cIAP2 are highly up-regulated in breast cancer cells by E2 and cytokines PMID: 21152357
40. These data reveal a novel mechanism for the inhibition of hepatitis B virus replication by cIAP2 via acceleration of the ubiquitin-proteasome-mediated decay of polymerase. PMID: 21865390
41. API2-MALT1 fusion gene is a distinctive genetic aberration in MALT lymphomas, and is not present in diffuse large B cell lymphoma. PMID: 20079017
42. Adenosine downregulated the expression of mRNAs and proteins for Bcl-X(L) and inhibitor of apoptosis protein 2 (IAP2) to directly inhibit caspase-3, -7, and -9, but upregulated the expression of mRNA and protein for DIABLO, an inhibitor of IAPs. PMID: 20063052
43. Arsenic trioxide suppresses transcription of cIAP2 mRNA in NB-4 cells. PMID: 19763917
44. These results support a role for Tax-dependent cIAP-2 expression in preventing the death of naturally infected CD8(+) cells and thereby in their clonal expansion in vivo. PMID: 20863547
45. TTP can bind to the 2nd AU-rich elements of cIAP2 mRNA 3'UTR and destabilize cIAP2 mRNA by forming complexes with Dcp2 and Xrn1. PMID: 20691152
46. Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells. PMID: 20576118
47. cancer cell lines evade Smac mimetic-induced apoptosis by up-regulation of cIAP2, which although initially degraded, rebounds. cIAP2 is induced by TNFalpha via NF-kappaB and modulation of the NF-kappaB signal renders cells sensitive to Smac mimetics PMID: 20547836
48. crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes; biochemical, structural, and cell biological studies on the interaction between TRAF2 and cIAP2 and on the ability of TRAF1 to modulate this interaction PMID: 20385093
49. Results provide the first structures of BIR domains from human NAIP and cIAP2. PMID: 19923725
50. REVIEW: Genetic alterations involving API2 underlying the pathogenesis of MALT lymphoma PMID: 11960389

显示更多

收起更多

A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

Cytoplasm. Nucleus.

IAP family

Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

HGNC: 591

OMIM: 601721

KEGG: hsa:330

STRING: 9606.ENSP00000263464

UniGene: Hs.127799