Your Good Partner in Biology Research

  1. 首页
  2. 试剂盒
  3. 酶联免疫试剂盒
  4. Human Angiopoietin-1(ANGPT1) ELISA kit

Human Angiopoietin-1(ANGPT1) ELISA kit

  • 中文名称：
    人血管生成素1(ANGPT1)酶联免疫试剂盒
  • 货号：
    CSB-EL001706HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        ANGPT1 (Angiopoietin 1)是一种由血管平滑肌细胞和其他细胞产生的分泌性蛋白质，参与血管新生和维持正常血管的稳定性。它结合并激活血管内皮细胞上的TIE2受体，促进血管生成和血管壁完整性的维持。
     
        j9九游会登录入口首页生物所提供的Human Angiopoietin-1(ANGPT1) ELISA kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、组织匀浆、细胞培养上清样本中的ANGPT1，其灵敏度为0.091 ng/mL，检测范围为1.25 ng/mL-80 ng/mL。
     
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates, cell culture supernates
  • 检测范围：
    1.25 ng/mL-80 ng/mL
  • 灵敏度：
    0.091 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：

     

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

     

  • 线性度：

     

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

     

  • 标准曲线：

     

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

     

  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
        最近的研究表明，ANGPT1在调节血管通透性和血管生成方面发挥着重要作用。它的缺失可能导致血管渗漏和心血管疾病等疾病的发生。最近的研究还发现，ANGPT1可以作为一种潜在的治疗靶点，用于治疗多种疾病，如肿瘤、心血管疾病和肾病等。
  • 功能：
    Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 484

    OMIM: 601667

    KEGG: hsa:284

    STRING: 9606.ENSP00000428340

    UniGene: Hs.369675