Your Good Partner in Biology Research

  1. 首页
  2. 试剂盒
  3. 酶联免疫试剂盒
  4. Dog clusterin,CLU ELISA Kit

Dog clusterin,CLU ELISA Kit

  • 中文名称：
    犬凝聚素(CLU)酶联免疫试剂盒
  • 货号：
    CSB-E13770c
  • 规格：
    96T/48T
  • 价格：
    ￥4200/￥3000
  • 其他：

产品详情

  • 产品描述：
        CLU，全名Clusterin，是一种分泌型糖蛋白，参与多种生物过程，如细胞存活、凋亡、脂质运输和免疫反应等。它在阿尔茨海默病、癌症和心血管疾病等疾病中可能扮演重要角色。CLU还具有与肿瘤相关的生物标志物的特性，成为了癌症早期诊断和治疗的研究方向之一。
        j9九游会登录入口首页生物所提供的Dog clusterin,CLU ELISA Kit属于ELISA检测试剂盒，采用竞争法定量检测狗血清、血浆、组织匀浆样本中的CLU，其灵敏度为4.963 ng/mL，检测范围为7.813 ng/mL-500 ng/mL。
     
  • 别名：
    CLUClusterin ELISA kit; Glycoprotein 80 ELISA kit; Gp80) [Cleaved into: Clusterin beta chain; Clusterin alpha chain] ELISA kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    7.813 ng/mL-500 ng/mL
  • 灵敏度：
    4.963 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 测定原理：
    quantitative
  • 测定方法：
    Competitive
  • 数据处理：
  • 货期：
    3-5 working days

引用文献

产品评价

靶点详情

  • 最新研究进展：
    CLU（也称为apoJ）是一种高度保守的糖蛋白，广泛存在于多种细胞类型和组织中。CLU参与了多种生物学过程，包括细胞凋亡、炎症、脂代谢和细胞迁移等。最近的研究表明，CLU与多种疾病的发生和发展有关，如癌症、心血管疾病、神经系统疾病和肝病等。此外，CLU还可能作为生物标志物来评估某些疾病的诊断和预后。
     
  • 功能：
    Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Following stress, promotes apoptosis. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3. Plays a role in the clearance of immune complexes that arise during cell injury.
  • 基因功能参考文献：
    1. Real time RT-PCR and western blotting analysis indicated there was a greater abundance of clusterin in cryptorchid dog testes. Furthermore, clusterin was detected in extracellular regions of cryptorchid dog testes. PMID: 29678567
    2. Clusterin may potentially serve as a marker for chronic spinal cord disease in the dog. PMID: 23990410
    3. The chaperone action of clusterin targets prefibrillar species to inhibit amyloid formation PMID: 17412999
    4. The extracellular chaperone clusterin appears in the cytosol during endoplasmic reticulum stress PMID: 17451556
    5. The chaperone action of clusterin is important in quality control of extracellular protein folding PMID: 19878774
    6. The chaperone clusterin mediates systemic clearance of extracellular misfolded proteins PMID: 21505792
    7. Clusterin is an extracellular holdase-type chaperone PMID: 10066740
    8. The chaperone action of clusterin is like that of the small heat shock proteins PMID: 10694874
    9. The chaperone action of clusterin is independent of ATP PMID: 11123922
    10. Clusterin expression may increase cardiac progenitor cell migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner. PMID: 20813109

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted. Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Mitochondrion. Mitochondrion membrane. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, chromaffin granule.
  • 蛋白家族：
    Clusterin family
  • 数据库链接：