Your Good Partner in Biology Research

  1. 首页
  2. 试剂盒
  3. 酶联免疫试剂盒
  4. Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit

Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit

  • 中文名称：
    犬单核细胞趋化蛋白1(MCP-1/CCL2/MCAF)酶联免疫试剂盒
  • 货号：
    CSB-E15747c
  • 规格：
    96T/48T
  • 价格：
    ￥4200/￥3000
  • 其他：

产品详情

  • 产品描述：
        CCL2蛋白是一种趋化因子，属于C-C趋化因子家族，也被称为单核细胞趋化蛋白-1（MCP-1）。它主要由多种细胞产生，如巨噬细胞、树突状细胞、内皮细胞、纤维细胞和肌肉细胞等，并且能够吸引单核细胞和记忆性T细胞等炎症细胞进入炎症部位。
        CCL2蛋白的生物学作用主要是通过结合其相应的受体CCR2来实现。CCR2广泛分布于多种免疫细胞表面，如单核细胞、记忆性T细胞、树突状细胞等。它参与了多种炎症、免疫调节和疾病发生等生理过程。
        CCL2蛋白在多种疾病的发生和发展中发挥着重要作用，如动脉粥样硬化、肿瘤、炎症性肠病、感染性疾病等。因此，CCL2蛋白被认为是这些疾病的潜在治疗靶点。一些针对CCR2的药物已经在研发过程中，有望成为治疗相关疾病的新型治疗药物。
        综上所述，CCL2蛋白是一种重要的趋化因子，通过结合其相应的受体CCR2在免疫细胞的活化、炎症和免疫调节等方面发挥重要作用。对其生物学作用的深入研究有助于发掘其在疾病治疗方面的潜在应用价值。
        j9九游会登录入口首页生物所提供的Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit属于ELISA检测试剂盒，采用双抗夹心法定量检测狗血清、血浆、组织匀浆样本中的CCL2，其灵敏度为0.147 ng/mL，检测范围为0.125 ng/mL-8 ng/mL。
     
  • 别名：
    CCL2 ELISA Kit; MCP1 ELISA Kit; SCYA2C-C motif chemokine 2 ELISA Kit; Monocyte chemoattractant protein 1 ELISA Kit; Monocyte chemotactic protein 1 ELISA Kit; MCP-1 ELISA Kit; Small-inducible cytokine A2 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.125 ng/mL-8 ng/mL
  • 灵敏度：
    0.147 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
        CCL2，全称为趋化因子C-C motif ligand 2，也称为单核细胞趋化蛋白1（MCP-1）。它是一种细胞因子，参与了许多生理和病理过程，如炎症、肿瘤、自身免疫性疾病等。CCL2主要由单核细胞、巨噬细胞和内皮细胞分泌，在炎症和组织损伤时被激活。CCL2可引导单核细胞、记忆性T细胞和树突状细胞等进入炎症和损伤组织，促进炎症反应和组织修复。CCL2也参与了肿瘤的发生和发展，可以引起肿瘤相关的炎症反应，增加肿瘤细胞的浸润和转移。
     
  • 功能：
    Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. May play a significant role in monocyte trafficking into the reperfused myocardium.
  • 基因功能参考文献：
    1. Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983 PMID: 29304171
    2. data suggest that CCL2 acts as a PMNs chemotactic factor as well as CXCL8, and both CCL2 and CXCL8 facilitate the infiltration of PMNs into the joints of idiopathic polyarthritis PMID: 27863550
    3. The study findings suggest that both CCL2 and CXCL8 are involved in the pathogenesis of canine idiopathic pulmonary fibrosis. PMID: 26231926
    4. CCL2 concentrations might be related to the breed predisposition of the West Highland white terrier for canine idiopathic pulmonary fibrosis. PMID: 26267090
    5. MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs. PMID: 22986270
    6. Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10. PMID: 18717642

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Endothelium of small veins and intrafascicular veins, and infiltrating leukocytes.
  • 数据库链接：