Atf4
ATF4，即激活转录因子4，别名CREB-2。ATF4是一种碱性区域亮氨酸拉链转录因子，属于bZIP家族成员，由人类基因组中的ATF4基因编码。它在细胞对多种应激反应的调控中发挥关键作用，包括氨基酸缺乏、氧化应激和内质网应激等。ATF4的作用机制主要是通过结合到目标基因的启动子区域上的cAMP响应元件（CRE）或相关的DNA序列，调节下游基因的转录。ATF4在生物学上的意义主要体现在其对细胞代谢、存活和应激反应的调控。它参与调节氨基酸代谢、抗氧化反应、蛋白质折叠和损伤修复等过程。在内质网应激时，ATF4能够激活未折叠蛋白反应（UPR），帮助细胞恢复蛋白质稳态。此外，ATF4还参与调节细胞周期、细胞凋亡以及自噬等过程，影响细胞的命运。ATF4的功能异常与多种疾病相关，包括代谢性疾病、神经退行性疾病和某些类型的癌症，因此，它也是药物开发中的一个潜在靶点。
热销产品
Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) (CSB-EP880648RA)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ATF4 Antibody (CSB-PA002272KA01HU)
验证数据
Western blot analysis of extracts from mouse craniofacial and mouse gastrocnemius, using ATF4 antibody.
Immunohistochemistry of paraffin-embedded Breast cancer using ATF4 Antibody.
Atf4 Antibodies
Atf4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002272GA01HU | ATF4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002272KA01HU | ATF4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA599947 | Phospho-ATF4 (Ser245) Antibody | Human | ELISA,WB,IHC |
| CSB-PA172388 | Phospho-ATF4 (Ser219) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA123639 | ATF4 (Ab-219) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA001783 | ATF4 Antibody | Human | WB, IHC, ELISA |
| CSB-PA020024 | Phospho-ATF4 (S245) Antibody | Human | IHC, ELISA |
| CSB-PA020025 | Phospho-ATF4 (S219) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA020026 | ATF4 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA038092 | ATF4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA994815 | ATF4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA002272A0HU | ATF4 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC, IP |
| CSB-PA002272LA01HU | ATF4 Antibody | Human | ELISA, IHC, IF |
| CSB-PA002272LB01HU | ATF4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA002272LC01HU | ATF4 Antibody, FITC conjugated | Human | |
| CSB-PA002272LD01HU | ATF4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA002272LA11HU | ATF4 Antibody | Human | ELISA, WB, IHC |
| CSB-PA002272LB11HU | ATF4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA002272LC11HU | ATF4 Antibody, FITC conjugated | Human | |
| CSB-PA002272LD11HU | ATF4 Antibody, Biotin conjugated | Human | ELISA |
Atf4 Proteins
Atf4 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002272MO CSB-EP002272MO CSB-BP002272MO CSB-MP002272MO CSB-EP002272MO-B |
Recombinant Mouse Cyclic AMP-dependent transcription factor ATF-4 (Atf4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atf4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002272HU CSB-EP002272HU CSB-BP002272HU CSB-MP002272HU CSB-EP002272HU-B |
Recombinant Human Cyclic AMP-dependent transcription factor ATF-4 (ATF4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atf4 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP669151BO CSB-EP669151BO CSB-BP669151BO CSB-MP669151BO CSB-EP669151BO-B |
Recombinant Bovine Cyclic AMP-dependent transcription factor ATF-4 (ATF4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atf4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP747361DIL CSB-EP747361DIL CSB-BP747361DIL CSB-MP747361DIL CSB-EP747361DIL-B |
Recombinant Danio rerio Cyclic AMP-dependent transcription factor ATF-4 (atf4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atf4 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP880648RA CSB-BP880648RA CSB-EP880648RA-B |
Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP880648RA | Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) | E.coli |
| CSB-CF880648RA | Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) | in vitro E.coli expression system |
