Recombinant Mouse Neuronal acetylcholine receptor subunit beta-2 (Chrnb2)

1. Data suggest that receptor complex assembly from Chrna4 and Chrnb2 on neuronal cell surface is up-regulated by nicotine; combined effects of increased assembly stoichiometry and preferential trafficking likely drive up-regulation of this receptor complex on neuronal cell surface upon nicotine exposure. (Chrna4 = a4 nicotinic receptor; Chrnb2 = b2 nicotinic receptor) PMID: 29074617
2. study provides evidence that alpha6beta2 nAChRs are involved in locomotor activity as well as ethanol and saccharin consumption in adolescent animals PMID: 28457669
3. Results suggest that alpha4beta2( *) nAChRs can produce sustained regulation of inhibitory post-synaptic GABA currents, in fast-spiking layer V neurons of the mouse frontal area 2. PMID: 27793780
4. beta2 containing nicotinic acetylcholine receptors play roles in the memory deficits associated with dentate-gyrys specific amyloid beta expression. PMID: 27522251
5. our results show that the beta2V287L ADNFLE mutation increases the ACh sensitivities of both HS and LS alpha4beta2 nAChRs (but not that of alpha5alpha4beta2 nAChRs). PMID: 27336596
6. Varenicline treatment may prevent scopolamine-induced memory disturbance by a molecular mechanism that may involve increased alpha4beta2 nAChR availability. Varenicline dose-dependently increased protein expression of both the alpha4 and beta2 subunit in cell cultures and brain tissues, respectively, but had no effect on mRNA expression; lack of change in mRNA expression suggests a still unknown post-transcriptional me... PMID: 27012889
7. MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in type 2 diabetes. PMID: 26904947
8. Results demonstrate that high-affinity alpha4beta2 nicotinic acetylcholine receptors are necessary for the effects of acute nicotine on contextual fear extinction. PMID: 26688111
9. Chrna7-deficient mice exhibit sustained attention impairments that are reversed by Chrnb2 activation PMID: 26222090
10. results reveal an unanticipated role for subcortical nAChRs in motivation induced by expected uncertainty. PMID: 26780509
11. Phenotype of layer V pyramidal cellss in aged Chrnb2 knockout mice is the result of the interaction of aging with the absence of high-affinity nAChRs over a relatively prolonged period of life span PMID: 24554727
12. results showed that precipitated and spontaneous nicotine withdrawal-induced anhedonia was attenuated in beta2 knock-out mice. PMID: 25107281
13. Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively PMID: 26276394
14. cotinine alters the assembly and trafficking of alpha4beta2 nicotinic acetylcholine receptors PMID: 26269589
15. The study shows that nAChR alpha4 beta2 sensitizes a MAPK-linked toxicity pathway on prolonged exposure to ABETA (1-42). PMID: 26139609
16. This experiments establish a firm causal link between Chrnb2 retinal waves, and visual circuit development and demonstrate that spontaneous retinal waves are necessary and instructive for circuit refinement in the developing nervous system PMID: 25466916
17. Lynx1 has a role in shifting alpha4beta2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum PMID: 25193667
18. Data suggest that the beta2 subunit of the nAChR is involved in the nicotine-induced inhibition of resident macrophages in stomach. PMID: 24223920
19. This study demonistrated that Genetic deficiency of beta2-containing nicotinic receptors attenuates brain injury in ischemic stroke in mice. PMID: 24184117
20. anatomical and developmental evidence suggests that the nAChR alpha7 and beta2 subunits may involve in the early direction-selectivity formation of DS RGCs in the mouse retina. PMID: 24631336
21. Cerebral cortex beta2 nAChR subunits increased in rats given nicotine or varenicline, but subunits from rats given saline or saz-A during the phase 2 treatment were not significantly different from all-phase saline controls. PMID: 24422997
22. By stimulating alpha4beta2-nicotinic acetylcholine receptors in the prefrontal cortex, working memory deficits are alleviated in aged mice. PMID: 23352115
23. Inhibition of alpha7 nicotinic acetylcholine receptors protects the function of acute hippocampal slices against excitotoxicity in an alpha4beta2-dependent manner. PMID: 23280428
24. Our findings suggest nAChR beta2 as a prominent pathway for nicotine induced impairment of NK cell functions which contributes to the occurrence of smoking-related pathologies PMID: 23469004
25. prospectively carried out a high-resolution 3-T magnetic resonance imaging (MRI) study in an ADNFLE family containing 10 affected members including one pharmacoresistant patient and carrying the V287L mutation of the CHRN beta2 subunit PMID: 22897520
26. post-receptor calcium-dependent mechanisms associated with nicotine withdrawal are mediated through beta2-containing nicotinic receptors PMID: 23313759
27. beta2*- and alpha9*-nAChRs, in addition to alpha7-nAChRs, have different roles in endogenous and nicotine-dependent modulation of immune functions and could be exploited as therapeutic targets to modulate inflammation and autoimmunity. PMID: 23399696
28. Data indicate that functional alpha4/beta2 nicotinic acetylcholine receptors (alpha4beta2 nAChR) plays a role in proliferation and differentiation fate into a neuronal lineage in neural progenitors of developing neocortex. PMID: 23056257
29. mice which lack nAChRs containing the beta2 subunit (beta2* nAChRs) exhibit compromised auditory discrimination, suggesting that beta2* nAChRs are necessary for normal auditory discrimination or that beta2* nAChRs play a critical role in auditory pathway development. PMID: 22433585
30. beta2-nAChRs are essential for acquisition of normal numbers of dendritic spines during development. PMID: 22699919
31. Varenicline acts as a functional antagonist of Chrnb2, blocking certain effects of nicotine. PMID: 22241831
32. Our results support the view that beta2*nAChRs modulate the prefrontal cortex (PFC) activity, specifically in flexible choice making PMID: 21810785
33. beta2-nicotinic acetylcholine receptors are implicated in the recruitment of inhibitory control of nociception, as shown by delayed recovery from capsaicin-induced allodynia. PMID: 21794985
34. find that Trask expression is retained, reduced or sometimes lost in some tumors compared with their normal epithelial tissue counterparts PMID: 21706059
35. structural changes indicative of accelerated aging are evident in young beta2 -/- mice, the data suggest however, that nAChRs do not directly regulate expression of survival genes. PMID: 21939740
36. A novel mutant mouse harboring the human ADNFLE mutation in the Chrnb2 gene was generated and used to study the roles of beta2* nicotinic receptors in complex biological processes including the activity-rest cycle, natural reward and anxiety. PMID: 20603624
37. The data of this study provided evidence for an important role of beta2*nAChRs in tasks involving motivation ranking. PMID: 21784105
38. These findings suggested that disrupting nicotinic receptors fundamentally alters the mechanisms and timing of excitation in prefrontal attentional circuitry. PMID: 22072695
39. chronic nicotine substantially increased the number of alpha4beta2-containing vesicle fusions at the plasma membrane; this stage in alpha4beta2 nAChR up-regulation is presumably downstream from increased endoplasmic reticulum exit PMID: 21768117
40. Protection from acoustic trauma in older Chrnb2 knockout mice is mainly mediated by an age-related increase of corticosterone. PMID: 21272629
41. That dopaminergic Chrnb2 are involved in nicotine CPP, anxiety reduction, and locomotor suppression. PMID: 21795541
42. Data SHOW that social interactions particularly mobilize the PrL area of the mouse PFC and that the presence of functional PrL beta2*-nAChRs is necessary for the integrated behavior to emerge. PMID: 21402717
43. The retinas of Chrnb2-/- mutants are normal in appearance, but the increased expression of these genes may also be involved in the abnormal projection patterns of RGC to the LGN. PMID: 21547082
44. findings show expression of beta2*-nAChRs is necessary for optimal attentional performance and that restoring expression of beta2*-nAChRs in the medial prefrontal cortex prelimbic area is sufficient for optimal performance PMID: 21836018
45. In the acute MPTP model of Parkinson's disease, time-courses of altered expression for nAChR alpha7, alpha4 and beta2 subunits closely mirrored the deficits observed in animal motor activity PMID: 21406211
46. Expression of beta2-nicotinic acetylcholine receptors only in retinal ganglion cells shows that not merely the presence, but the precise spatiotemporal pattern of spontaneous retinal activity instructs neural circuit development. PMID: 21689598
47. propose that in the P3 superior cervical ganglion of wild type mice, alpha3beta4 (+/-alpha5) represent about 62% of receptors, whereas 17% are alpha3beta2beta4, and 21% are alpha4beta2 (+/-alpha5) receptors PMID: 21485013
48. the beta2 nicotinic receptor subunit is involved in the dendritic morphogenesis of pyramidal neurons and in the circuits that contribute to the high-order functional connectivity of the cerebral cortex PMID: 20534523
49. Prefrontal alpha4beta2* nAChRs play a key role in evoking and facilitating the transient glutamatergic-cholinergic interactions that are necessary for cue detection and attentional performance. PMID: 20203212
50. Results show thatlynx1 promotes the largest of three current amplitudes elicited by ACh through alpha(4)beta(2) nAChRs and that lynx1 enhances receptor desensitization. PMID: 11906696

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KEGG: mmu:11444

STRING: 10090.ENSMUSP00000029562

UniGene: Mm.35088