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  4. Recombinant Mouse Histamine H3 receptor (Hrh3)

Recombinant Mouse Histamine H3 receptor (Hrh3)

  • 中文名称：
    小鼠Hrh3重组蛋白
  • 货号：
    CSB-CF010739MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Hrh3; Histamine H3 receptor; H3R; HH3R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-445
  • 氨基酸序列
    MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAA ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR RAFTKLLCPQKLKVQPHGSLEQCWK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).
  • 基因功能参考文献：
    1. The H3 receptor in the dorsal striatum is a contributor to repetitive behavioral pathology. PMID: 28117842
    2. H3R activation with the agonist R-(-)-alpha-methylhistamine to produce a unique time- and cell type-dependent profile of molecular signaling events in the striatum. PMID: 27510032
    3. H3R is an important regulator of sensorimotor gating, and the lack of H3R significantly modifies striatal dopaminergic PMID: 26945087
    4. Data show that knockout of histamine receptor H3 (Hrh3 receptor) caused a substantial reduction of free-running activity rhythm amplitude. PMID: 26660098
    5. These results suggest that H3 receptor may participate in the maintenance of the relaxed state and prevention of over-contraction in mature differentiated myotubes. PMID: 25746421
    6. Histamine H3 receptors were expressed in mouse beta cells and could play a role in insulin secretion and, possibly, beta cell proliferation. PMID: 24117016
    7. Hrh3 polymorphisms between EAE-susceptible and resistant SJL and B10.S mice PMID: 23894272
    8. Greater slow wave sleep increases are found in histamine H3 knock-out mice compared to wild-type mice, consistent with enhanced histamine transmission. PMID: 23303066
    9. ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R. PMID: 22870296
    10. Evidence for the role of histamine H3 receptor was found in alcohol-related behaviors, especially in alcohol drinking and alcohol reward. PMID: 21654737
    11. An increased expression of H3 receptors in HDC KO mice without any changes in the spontaneous firing of "histaminergic" neurons without histamine and their responses to the H3 receptor agonist (R)-alpha-methylhistamine. PMID: 21710252
    12. These findings demonstrate that manipulation of central histamine H3 receptor by proxyfan can significantly improve glucose excursion by increasing plasma insulin levels via a glucose-independent mechanism. PMID: 21239440
    13. D(1)-H(3) receptor heteromers work as processors integrating dopamine- and histamine-related signals involved in controlling the function of striatal neurons of the direct striatal pathway. PMID: 21173143
    14. In this review conditioned place preference induced by alcohol is stronger in histidine decarboxylase-deficient mice than in control mice. PMID: 20864504
    15. Methamphetamine- and MDMA-induced behavioral changes in Hrh3 knockout mice are reported. PMID: 19783867
    16. The aim of this work was to investigate the effects of essential splice signals on intron retention in histamine H3 receptors and to identify sequence elements that determine the differences in splicing between rats and mice. PMID: 19446035
    17. These results suggest that neuronal histamine is a mediator of body-weight homeostasis and that neuronal histamine functions through H3 receptors in mice. PMID: 12488429
    18. Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors. PMID: 12527809
    19. Data support a protective antiarrhythmic role of histamine H(3)-receptors in myocardial ischemia. PMID: 12810089
    20. These findings support a role for H3Rs in mediating histamine effects on spatial learning and memory and measures of anxiety. PMID: 15078574
    21. Histamine H3 receptor activation hyperpolarized substantia nigra pars reticulata and thus decreasing the intensity of basal ganglia output. [histamine h3 receptor] PMID: 16738217
    22. brain H3Rs play a pivotal role in drinking behavior in response to dehydration and AT-II PMID: 16887177
    23. Central Hrh3 signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS. PMID: 17548817
    24. These results indicate distinctive roles of histamine H(3) receptors in various orexigenic pathways PMID: 18037404
    25. Report participation of histamine H3 receptors in experimental allergic rhinitis of mice. PMID: 18845911
    26. Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria PMID: 19547708
    27. H3R stimulation could have a neuroprotective effect that may help in understanding the impact of H3R signaling in the central nervous system. PMID: 19549072
    28. H3 protein expression was found in vestibular neurons of mice characterized by large and roundish soma, which labeled for calretinin and calbindin. PMID: 19563635

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:99296

    STRING: 10090.ENSMUSP00000049963

    UniGene: Mm.285360