Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Beta-tectorin (Tectb)

Recombinant Mouse Beta-tectorin (Tectb)

  • 中文名称：
    小鼠Tectb重组蛋白
  • 货号：
    CSB-CF023371MO
  • 规格：
    ￥5028
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Tectb
  • Uniprot No.：
  • 别名：
    Tectb; Beta-tectorin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    36.5kDa
  • 表达区域：
    18-305aa
  • 氨基酸序列
    KSCTPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDSTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSTKKEAPFVLETSEIGSDLFAGVEAKGLSVRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGKDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVNCDKRKRMLRDQTGGVLVVELSLRSRA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    The cDNA fragment encoding 18-305aa of Mouse Beta-tectorin/Tectb was fused with an N-terminal 6xHis-tag and then expressed in vitro E.coli expression system. The product obtained is the Recombinant full-length of mature Mouse Tectb protein. Its purity was determined by using SDS-PAGE and reached up to 90%. On the reducing SDS-PAGE gel, there presented a molecular mass band of about 38 kDa. The slightly higher result was attributed to glycosylation. This recombinant Tectb protein may be used for specific antibody production or on the studies of the tectorial membrane (TM).

    Tectb is a non-collagenous glycoprotein localized to the TM. It is exclusively highly expressed in the inner ear. The absence of Tecb impairs TM's core structure and significantly alters the cochlear function. Remarkable sensitivity and exquisite frequency selectivity are hallmarks of mammalian hearing. Roozbeh Ghaffari etc. demonstrated that Tectb mutation-mediated the reduction of the spatial extent and propagation velocity of TM traveling waves is probably responsible for all the hearing abnormalities related to the mutation. The deletion of the tectb gene in the mouse model showed reduced sensitivity and sharper frequency selectivity.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
  • 数据库链接：

    KEGG: mmu:21684

    STRING: 10090.ENSMUSP00000025936

    UniGene: Mm.42139