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  4. Recombinant Mouse Adrenocorticotropic hormone receptor (Mc2r)

Recombinant Mouse Adrenocorticotropic hormone receptor (Mc2r)

  • 中文名称：
    小鼠Mc2r重组蛋白
  • 货号：
    CSB-CF723737MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Mc2r; Acthr; Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-296
  • 氨基酸序列
    MKHIINSYEHTNDTARNNSDCPDVVLPEEIFFTISVIGILENLIVLLAVIKNKNLQSPMY FFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSFESTADDIIDCMFILSLLGSIFS LSVIAADRYITIFHALQYHSIVTMRRTIITLTIIWMFCTGSGITMVIFSHHIPTVLTFTS LFPLMLVFILCLYIHMFLLARSHARKISTLPRTNMKGAMTLTILLGVFIFCWAPFVLHVL LMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKRMLFCNRY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
  • 基因功能参考文献：
    1. JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. PMID: 28146118
    2. Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice. PMID: 24742195
    3. MC2R plays an important role for regular lipolytic function and lipid composition in 3T3-L1 adipocytes. PMID: 22723268
    4. Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells. PMID: 22306084
    5. melanocortin 2 receptor and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes PMID: 21616121
    6. MC2R+/- pups delivered from MC2R-/- females crossed with MC2R+/+ males mice thrived poorly with MC2R-/- mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R-/- females are poor mothers or cannot nurse. PMID: 21303938
    7. The promoter activity of Mc2r is activated by FOXL2 in a dose-dependent manner; transcriptional activity of Mc2r is up-regulated by synergistic interaction of FOXL2 and NR5A1. PMID: 20650879
    8. MC2R in Y1 cells internalizes by a G protein coupled receptor kinase dependent clathrin-coated pit mechanism. PMID: 12530627
    9. Data show that adrenocorticotrophic hormone resistance in tumor cell mutants is associated with a base change polymorphism in the steroidogenic factor 1 gene. PMID: 12851310
    10. Novel 135-bp exon 1f of ACTH-R gene was located 1.4 kb downstream in genome of exon 1a transcribed in adrenal gland. Promoter region flanking to exon 1f may be essential for adipose tissue; that flanking to exon 1a is specific for the adrenal gland. PMID: 15004405
    11. a novel mechanism for mc2-r transcription, which may have significance in both adrenal and extra-adrenal sites of expression PMID: 15028712
    12. Mc2r expression is associated with a less aggressive tumor phenotype and anti-proliferative effects can be amplified through stimulation with physiological doses of ACTH. PMID: 16131607
    13. A CCAAT/enhancer-binding protein binding site, 87 bp upstream of the transcriptional initiation site, is necessary for the activity of Mc2R promoter. PMID: 16997835
    14. MC2-R gene is regulated both transcriptionally and post-transcriptionally during adipogenesis PMID: 17170082
    15. MC2R is required for postnatal adrenal development and adrenal steroidogenesis and that MC2R KO mice provide a useful animal model by which to study familial glucocorticoid deficiency PMID: 17989225
    16. The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. PMID: 18162519
    17. MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal. PMID: 18981183
    18. Results describe the phenotype of mice deficient in melanocortin 2 receptor on a B6/Balbc mix background. PMID: 19022343
    19. The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor. PMID: 19535343

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:17200

    STRING: 10090.ENSMUSP00000058691

    UniGene: Mm.426053