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  4. Recombinant Human cytomegalovirus Envelope glycoprotein US27 (US27)

Recombinant Human cytomegalovirus Envelope glycoprotein US27 (US27)

  • 中文名称：
    Recombinant Human cytomegalovirus Envelope glycoprotein US27(US27)
  • 货号：
    CSB-CF518995HWW
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    US27
  • Uniprot No.：
  • 别名：
    US27; Envelope glycoprotein US27
  • 种属：
    Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-364
  • 氨基酸序列
    MTTSTTTTTNIMLQVSNVTNHTLNSTEIYQLFEYTRFGVWLMCIVGTFLNMLVITTILYY RRKKKSPSDTYICNLAVADLLIVVGLPFFLEYAKHHPKLSREVVCSGLNACFYICLFAGV CFLINLSMDRYCVIVWGVELNRVRNNKRATCWVVIFWILAALMGMPHYLMYSHTNNECVG EFANETSGWFPVFLNTKVNICGYLAPIVLMAYTYNRMVRFIINYVGKWHMQTLHVLLVVV VSFASFWFPFNLALFLESIRLLSGTQNETLQTVITFCLYVGQFLAYVRACLNPGIYILVG TQMRKDMWTTLRVFACCCVKQEIPYQDIDIELQKDIQRRAKHTKRTHYDRKHAPMESGEE EFLL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in spread of HCMV via the extracellular route. As a G-protein-coupled receptor (vGPCR), may activate signaling pathways important for virion assembly or egress processes.
  • 基因功能参考文献：
    1. US27 expression enhance HCMV infection by prolonging host cell survival and proliferation.[review] PMID: 28447191
    2. These results demonstrate that US27 can impact host cell physiology and may shed light on the function of this orphan viral G protein-coupled receptor. PMID: 23850869
    3. Potentiation of CXCR4 signaling by US27 could represent a novel strategy by which human cytomegalovirus targets virus-infected cells to the bone marrow in order to expand the reservoir of latently infected cells. PMID: 23490053
    4. The results indicate that the C-terminal domain of the HCMV US27 protein, which contains a di-leucine endocytic sorting motif, is both necessary and sufficient for intracellular localization. PMID: 22339884
    5. The s conclude that pUS27 acts at a late stage of the human cytomegalovirus replication cycle to support spread of virus by the extracellular route. PMID: 21307184

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  • 亚细胞定位：
    Virion. Host cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: vg:3077557