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  4. Recombinant Dictyostelium discoideum Sphingosine-1-phosphate lyase (sglA)

Recombinant Dictyostelium discoideum Sphingosine-1-phosphate lyase (sglA)

  • 中文名称：
    盘基网柄菌sglA重组蛋白
  • 货号：
    CSB-CF703834DKK
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    sglA
  • Uniprot No.：
  • 别名：
    sglA; DDB_G0282819; Sphingosine-1-phosphate lyase; S1P lyase; S1PL; SP-lyase; SPL; Sphingosine-1-phosphate aldolase
  • 种属：
    Dictyostelium discoideum (Slime mold)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-528
  • 氨基酸序列
    MDKANDYLKDYQPAKLVLATAGITAASILAYQAITDRDFKDKLNKKIFRSIKSMPGVSDI VKKERAKAKVELKKMFKTDVRNAHYTLPLKGIKHEDLIEEMKALAKVDESHWVDSKVSGC VYLGEKEHTKLLNEAYSLFSLSNPLHPSVFPSIRKFETESISMVSNMLNAHSKVVGSLTS GGTESIFMAVKAYRDFYKDRTDRPEIVVPVTIHAAFDKACEYLKIRIVHIDVDPVSYKVD MAAMKKAINKDTILVAGSAVNFPHGIIDPIDEIAKLAQQYDIGCHVDACLGGFILPFAEK LDYDIPVFDFRIPGVTSMSVDTHKFGYAAKGTSVVLFGNKKLRRAMYFVAPNWPGGIYAS PTLPGSRPGGLVAACWASLVSMGNDGFLEKAKGVMETTKKIIKGLQSINGVKIIGDPKAM VVAFTCDNIFYVNDYMSKKGWHLNALQRPNSLHVCVTAKMIGMESLFIEDLKDSIKLVKD NSGSLPKDGTAPIYGSAHSVPDREMVGTILSDFIDELITPDYKPSQST
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingosine-1-phosphate (S1P) probably acts intracellularly as a second messenger perhaps by promoting cell proliferation; the absence of S1P lyase increases its concentration. This leads to increased lateral pseudopod formation as well as defects in the efficiency of chemotaxis. Overexpression of S1P lyase causes decreased growth rates, entry into stationary phase at lower cell density and increased sensitivity to the antitumor agents cisplatin and carboplatin; these effects are more pronounced in cells that express more enzyme.
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    Group II decarboxylase family, Sphingosine-1-phosphate lyase subfamily
  • 数据库链接：

    KEGG: ddi:DDB_G0282819

    STRING: 44689.DDB0214888