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  4. Recombinant Rat Transforming growth factor beta receptor type 3 (Tgfbr3), partial

Recombinant Rat Transforming growth factor beta receptor type 3 (Tgfbr3), partial

  • 中文名称：
    大鼠Tgfbr3重组蛋白
  • 货号：
    CSB-YP023453RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Tgfbr3重组蛋白
  • 货号：
    CSB-EP023453RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Tgfbr3重组蛋白
  • 货号：
    CSB-EP023453RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Tgfbr3重组蛋白
  • 货号：
    CSB-BP023453RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Tgfbr3重组蛋白
  • 货号：
    CSB-MP023453RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tgfbr3
  • Uniprot No.：
  • 别名：
    Tgfbr3; Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
  • 基因功能参考文献：
    1. Mating decreases plasma levels of TGFbeta1 and regulates myosalpinx expression of TGFbeta1/TGFBR3 in the rat. PMID: 25359088
    2. Data present the 2.0-A resolution crystal structure of the betaglycan ZP-C region in combination with a downstream region known as the external hydrophobic patch. PMID: 21402931
    3. report detailing the distribution of betaglycan in mammalian reproductive tissues. support the hypothesis of a modulatory role for betaglycan in TGFbeta and/or inhibin effects in these tissues PMID: 11861534
    4. role for betaglycan in vivo as a coreceptor that is required for inhibin-modulated FSH release from the pituitary. PMID: 14500575
    5. TGF-betaR-III seems to be associated with newly formed blood vessels during neovascularization in wound healing. PMID: 15292974
    6. FSH and estradiol increased betaglycan mRNA expression, most possibly through the protein kinase A pathway and the estrogen receptor-beta. PMID: 15878966
    7. These results suggest a novel signaling mechanism for betaglycan, which is independent of the canonical TGF-beta signal pathway although it involves TGF-beta receptors and takes place through p38 pathways. PMID: 16413747
    8. A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats. PMID: 19019833
    9. Betaglycan is an endogenous inhibin coreceptor required for high-sensitivity inhibin antagonism of activin signaling in rat anterior pituitary gonadotropes. PMID: 19372236

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular space, extracellular matrix. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
  • 数据库链接：

    KEGG: rno:29610

    STRING: 10116.ENSRNOP00000002867

    UniGene: Rn.9953