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  4. Recombinant Rat Plasminogen (Plg)

Recombinant Rat Plasminogen (Plg)

  • 中文名称：
    大鼠Plg重组蛋白
  • 货号：
    CSB-YP018188RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Plg重组蛋白
  • 货号：
    CSB-EP018188RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Plg重组蛋白
  • 货号：
    CSB-EP018188RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Plg重组蛋白
  • 货号：
    CSB-BP018188RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Plg重组蛋白
  • 货号：
    CSB-MP018188RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Plg; Plasminogen; EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A; short form; Plasmin light chain B]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-812
  • 氨基酸序列
    D SLDGYVSTQG ASLHSLTKKQ LAAGSIADCL AKCEGETDFI CRSFQYHSKE QQCVIMAENS KTSSIIRMRD VILFEKRVYL SECKTGIGKG YRGTMSKTKT GVTCQKWSDT SPHVPKYSPS THPSEGLEEN YCRNPDNDEQ GPWCYTTDPD QRYEYCNIPE CEEECMYCSG EKYEGKISKT MSGLDCQSWD SQSPHAHGYI PAKFPSKNLK MNYCRNPDGE PRPWCFTTDP NKRWEYCDIP RCTTPPPPPG PTYQCLKGRG ENYRGTVSVT ASGKTCQRWS EQTPHRHNRT PENFPCKNLE ENYCRNPDGE TAPWCYTTDS QLRWEYCEIP SCGSSVSPDQ SDSSVLPEQT PVVQECYQGN GKSYRGTSST TNTGKKCQSW VSMTPHSHSK TPANFPDAGL EMNYCRNPDN DQRGPWCFTT DPSVRWEYCN LKRCSETGGG VAESAIVPQV PSAPGTSETD CMYGNGKEYR GKTAVTAAGT PCQEWAAQEP HSHRIFTPQT NPRAGLEKNY CRNPDGDVNG PWCYTMNPRK LYDYCNIPLC ASLSSFECGK PQVEPKKCPG RVVGGCVANP HSWPWQISLR TRFSGQHFCG GTLISPEWVL TAAHCLEKSS RPEFYKVILG AHEERILGSD VQQIAVTKLV LEPNDADIAL LKLSRPATIT DNVIPACLPS PNYVVADRTL CYITGWGETK GTPGAGRLKE AQLPVIENKV CNRAEYLNNR VKSTELCAGH LAGGIDSCQG DSGGPLVCFE KDKYILQGVT SWGLGCARPN KPGVYVRVSR YVNWIEREMR ND
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.; Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
  • 基因功能参考文献：
    1. Angiostatin overexpression was associated with attenuated renal disease progression in a model of chronic kidney injury, likely because of its anti-inflammatory actions. PMID: 18971211
    2. Expression of angiostatin in the ischemic tissues after ischemia-reperfusion in diabetes mellitus + cerebral ischemia group increased significantly. PMID: 19932587
    3. plasmin has a role as an intracellular protease PMID: 12928439
    4. Plasminogen-induced IL-1beta, TNF-alpha, and iNOS mRNA expression in primary cultured rat microglia and BV2 murine microglial cells. PMID: 14651966
    5. Plg gene expression is up-regulated by nerve growth factor PMID: 17663741
    6. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit PMID: 18981180

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family, Plasminogen subfamily
  • 数据库链接：

    KEGG: rno:85253

    STRING: 10116.ENSRNOP00000023370

    UniGene: Rn.20178