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  4. Recombinant Rat Fasciculation and elongation protein zeta-1 (Fez1)

Recombinant Rat Fasciculation and elongation protein zeta-1 (Fez1)

  • 中文名称：
    大鼠Fez1重组蛋白
  • 货号：
    CSB-YP008600RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Fez1重组蛋白
  • 货号：
    CSB-EP008600RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Fez1重组蛋白
  • 货号：
    CSB-EP008600RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Fez1重组蛋白
  • 货号：
    CSB-BP008600RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Fez1重组蛋白
  • 货号：
    CSB-MP008600RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fez1
  • Uniprot No.：
  • 别名：
    Fez1Fasciculation and elongation protein zeta-1; Zygin I; Zygin-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-393
  • 氨基酸序列
    MEAPLVSLDE EFEDIRPCCT EDPEEKPQSL YGTSPHHLED PSLSELENFS SEIISFKSME DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDTEIHE KEEEDEFIEK SENDSGINEE PLLTADQVIE EIEEMMQNSP DPEEEVEVLE EEDGGEISSQ ADSVLLQEMQ ALTQTFNNNW SYEGLRHMSG SELTELLDQV EGAIRDFSEE LVHQLARRDE LEFEKEVKNS FITVLIEVQN KQKEQRELMK KRRKEKGLSL QSSRIEKGNQ MPLKRFSMEG ISNILQSGIR QTFGSSGADR QYLNTVIPYE KKSSPPSVED LQMLTNILFA MKEDNEKVPT LLTDYILKVL CPT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.
  • 基因功能参考文献：
    1. Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking. PMID: 27247180
    2. DISC1 participates in neurite outgrowth through its interaction with FEZ1. PMID: 12874605
    3. FEZ1 showed high levels of expression, especially in developing hippocampal neurons. PMID: 14992819
    4. E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation PMID: 15466860
    5. FEZ1 promotes neurite extension through its interaction with microtubules, and agnoprotein facilitates JCV propagation by inducing the dissociation of FEZ1 from microtubules PMID: 15843383
    6. Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells. PMID: 15879557
    7. Therefore, our results strongly suggest that FEZ1 participates in the establishment of neuronal polarity by controlling the mitochondrial motility along axon. PMID: 17173861
    8. the FEZ1/kinesin complex functions for the transport of mitochondria along microtubules toward the extending neurites in differentiating PC12 cells. PMID: 17669366
    9. Immunocytochemistry revealed that FEZ1 was located in the astrocytic cytoplasm and cell processes but not the nucleus PMID: 19199094
    10. FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1 PMID: 19667186

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane.
  • 蛋白家族：
    Zygin family
  • 组织特异性：
    Brain.
  • 数据库链接：

    KEGG: rno:81730

    STRING: 10116.ENSRNOP00000008285

    UniGene: Rn.5468