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  4. Recombinant Mouse Uncharacterized protein C16orf73 homolog

Recombinant Mouse Uncharacterized protein C16orf73 homolog

  • 中文名称：
    小鼠Meiob重组蛋白
  • 货号：
    CSB-YP880497MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Meiob重组蛋白
  • 货号：
    CSB-EP880497MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Meiob重组蛋白
  • 货号：
    CSB-EP880497MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Meiob重组蛋白
  • 货号：
    CSB-BP880497MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Meiob重组蛋白
  • 货号：
    CSB-MP880497MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Meiob
  • Uniprot No.：
  • 别名：
    Meiob; Meiosis-specific with OB domain-containing protein; EC 3.1.-.-; Protein expressed in male leptotene and zygotene spermatocytes 675; MLZ-675
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-470
  • 氨基酸序列
    MAKFFALKNF TALSDLHPNM ANLKIIGIVI GKTDVKGFPD RKNIGSERYT FSFTIRDSPC HFVNVSSWGS EDYIRSLSES FRVAECVIIE NPLIQRKDTE REEKFSPATP SNYKLLLSEN HSMVKVCSPY EVDTKLLSLI HLPVKESRDY YSLADIVANG HSLDGRIINV LAAVRSVGEP KYFTTSDRRK GQRCEVKLFD ETEPSFTMTC WDNESILLAQ SWMARETVIF ASDVRINFNK FQNCMAATVI SKTIITVNPD TPEANILLNY IRENKETNVA DEIDSYLKES VNLNTIVDVY TVEQLKVKAL KSEGKADPFY GILYAYISTL NIDDETTKVV RNRCSSCGYI VNEASNTCTI CNQDSSRLKS FFLSFDVLVD LTDHTGTLHS CSLSGSIAEE TLGCTINEFL TMTSEQKTKL KWQLLLERSK IYLKLILSHR ARGGLKVTIL SCKLADPTEA SRNLARQGHT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro.
  • 基因功能参考文献：
    1. We find that MEIOB and SPATA22 form an obligate complex and contain defined interaction domains PMID: 28453612
    2. MEIOB and SPATA22 form an obligate complex and contain defined interaction domains. A single residue D383 in MEIOB is indispensable for the MEIOB-SPATA22 interaction. The MEIOB/SPATA22 complex interacts with the RPA heterotrimeric complex in a collaborative manner. PMID: 28453612
    3. MEIOB is required for meiotic recombination and chromosomal synapsis. PMID: 24240703
    4. MEIOB is a meiosis-specific paralogue of RPA1. MEIOB colocalizes with RPA in foci on meiotic chromosomes. MEIOB binds to single-stranded DNA and exhibits 3'-5' exonuclease activity. MEIOB forms a complex with RPA and with SPATA22. Chromatin localization and stability of MEIOB depends on SPATA22 and vice versa. MEIOB is essential for meiotic recombination in both sexes. PMID: 24240703
  • 亚细胞定位：
    Cytoplasm. Nucleus. Chromosome.
  • 蛋白家族：
    MEIOB family
  • 组织特异性：
    Sprecifically expressed in early meiotic germ cells: in adult and fetal tissues, detected in fetal ovary, postnatal testis and liver. In the ovary, expression starts at 12.5 dpc, reaches a maximum at 15.5 dpc and decreases to become undetectable in post n
  • 数据库链接：

    KEGG: mmu:75178

    STRING: 10090.ENSMUSP00000024972

    UniGene: Mm.52592