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  4. Recombinant Mouse Tropomyosin alpha-3 chain (Tpm3)

Recombinant Mouse Tropomyosin alpha-3 chain (Tpm3)

  • 中文名称：
    小鼠Tpm3重组蛋白
  • 货号：
    CSB-YP024106MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tpm3重组蛋白
  • 货号：
    CSB-EP024106MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tpm3重组蛋白
  • 货号：
    CSB-EP024106MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tpm3重组蛋白
  • 货号：
    CSB-BP024106MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tpm3重组蛋白
  • 货号：
    CSB-MP024106MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tpm3; Tpm-5; Tpm5; Tropomyosin alpha-3 chain; Gamma-tropomyosin; Tropomyosin-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-285
  • 氨基酸序列
    MMEAIKKKMQ MLKLDKENVL DRAEQAEAEQ KQAEERSKQL EDELATMQKK LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISDELDHALN DMTSI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
  • 基因功能参考文献：
    1. The role of TPM3.1 protein isoform in cell proliferation PMID: 26274783
    2. Tpm3 plays crucial roles in maintaining cortical actin integrity and asymmetric cell division during oocyte maturation, and that dynamic regulation of cortical actin by Tpm3 is critical to ensure proper polar body protrusion. PMID: 25483187
    3. TMBr-3 and TM5NM1 modestly affected actin assembly kinetics, in an opposite manner. PMID: 24124168
    4. Tropomyosin regulates cell migration during skin wound healing. PMID: 23303457
    5. Data conclude that exon 9d-containing isoforms are not essential for survival of neuronal cells and that isoform choice from the gamma-Tm gene is flexible in the brain PMID: 20223554
    6. Reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm of mice with diaphragmatic defects. PMID: 20024584
    7. Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation. PMID: 12234784
    8. low-molecular-weight products from the gammaTm gene are essential for both embryonic development and cell survival PMID: 14993271
    9. role of different gamma isoforms in neuronal function by knockout methods PMID: 15458840
    10. tropomyosin isoforms regulate neuronal size and shape PMID: 15888546
    11. Tm-3 is up-regulated during osteoclastogenesis, indicating potential cell-specific functions. PMID: 16765662
    12. results indicate that a Tm5NM1-defined actin cytoskeleton is required for the normal excitation-contraction coupling in skeletal muscle PMID: 19005216
    13. The expression of an inappropriate Tm in skeletal muscle results in increased susceptibility to contraction-induced damage PMID: 19530183

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  • 亚细胞定位：
    [Isoform 2]: Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tropomyosin family
  • 数据库链接：

    KEGG: mmu:59069

    UniGene: Mm.240839