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  4. Recombinant Mouse Transforming growth factor-beta-induced protein ig-h3 (Tgfbi)

Recombinant Mouse Transforming growth factor-beta-induced protein ig-h3 (Tgfbi)

  • 中文名称：
    小鼠Tgfbi重组蛋白
  • 货号：
    CSB-YP023450MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tgfbi重组蛋白
  • 货号：
    CSB-EP023450MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tgfbi重组蛋白
  • 货号：
    CSB-EP023450MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tgfbi重组蛋白
  • 货号：
    CSB-BP023450MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tgfbi重组蛋白
  • 货号：
    CSB-MP023450MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tgfbi
  • Uniprot No.：
  • 别名：
    TgfbiTransforming growth factor-beta-induced protein ig-h3; Beta ig-h3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-683
  • 氨基酸序列
    GPAKSPY QLVLQHSRLR GRQHGPNVCA VQKVIGTNKK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA LPLSNLYETM GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWSS LPAEVLDSLV SNVNIELLNA LRYHMVDRRV LTDELKHGMT LTSMYQNSNI QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE DTFETLRAAV AASGLNTVLE GDGQFTLLAP TNEAFEKIPA ETLNRILGDP EALRDLLNNH ILKSAMCAEA IVAGMSMETL GGTTLEVGCS GDKLTINGKA VISNKDILAT NGVIHFIDEL LIPDSAKTLL ELAGESDVST AIDILKQAGL DTHLSGKEQL TFLAPLNSVF KDGVPRIDAQ MKTLLLNHMV KEQLASKYLY SGQTLDTLGG KKLRVFVYRN SLCIENSCIA AHDKRGRFGT LFTMDRMLTP PMGTVMDVLK GDNRFSMLVA AIQSAGLMEI LNREGVYTVF APTNEAFQAM PPEELNKLLA NAKELTNILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS SKNNVVSVNK EPVAETDIMA TNGVVYAINT VLQPPANRPQ ERGDELADSA LEIFKQASAY SRAAQRSVRL APVYQRLLER MKH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in cell adhesion. May play a role in cell-collagen interactions.
  • 基因功能参考文献：
    1. Data suggest that big-h3 protein (BIGH3) acts as a tumor suppressor in the retina. PMID: 28099942
    2. findings demonstrate a novel role of lithium in the inhibition of colon cancer metastasis by blocking TGFBIp expression, and thereby TGFBIp-induced lymphangiogenesis, in primary tumors. PMID: 26857144
    3. TGF-beta-induced matricellular protein-null lungs displayed diminished elastic recoil and gas exchange efficiency PMID: 26878215
    4. Vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. PMID: 26084452
    5. the data suggest a model by which cytokine-induced Myt3 suppression leads to Tgfbi de-repression and subsequently to impaired islet-cell migration, revealing a novel role for Myt3 in regulating islet-cell migration. PMID: 26177052
    6. Studies reveal that growth hormone (GH)increases TGFBI expression in a mouse and rat models of diabetic nephropathy (DN) which correlate with clinical results, and suggest that this mechanism can explain the podocytes depletion in DN. PMID: 25740786
    7. Tgfbi deficiency is associated with the degradation of cartilage matrix PMID: 25450762
    8. The results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFbeta released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis. PMID: 25378215
    9. TGFBI is a potential risk gene for human diabetes. PMID: 24728038
    10. High blood TGFBIp levels were observed in cecal ligation and puncture (CLP)-induced septic mice. The absence of the TGFBIp gene in mice attenuated CLP-induced sepsis. PMID: 24506343
    11. Collectively, our findings indicate that betaig-h3 promotes the fibrogenic influence of TGFbeta signaling, neutralizing the prochondrogenic influence of the hypoxic-inducible factor 1 activated by the microenvironment of limb mesenchymal aggregates. PMID: 22924741
    12. the observed effect of TGFBI on bone mass and bone size was largely caused by the effect of TGFBI on periosteal bone formation PMID: 22644324
    13. betaig-h3 bears alphavbeta3 integrin-interacting motifs that mediate endothelial cell adhesion and migration and angiogenesis PMID: 12704192
    14. The spatiotemporal distribution of Beta-ig during various stages of murine development was examined and its ability to support adhesion of various cell types assessed PMID: 12963107
    15. During pregnancy, high levels of betaig-h3 mRNA were detected in the uterus on Day 4 of gestation, when the trophoblastic invasion of the implanted blastocysts was very active. PMID: 14967934
    16. Recombinant beta ig-h3 and its FAS1 domain significantly inhibit in vitro osteoblast differentiation as evaluated by matrix mineralization/bone nodule formation. PMID: 15780949
    17. analysis of mouse fasciclin-containing genes (betaigH3, periostin, stabilin-1, and stabilin-2) expression patterns during valvuloseptal morphogenesis PMID: 15907457
    18. keratoepithelin may help to build up a bridge between collagen VI and yet unidentified muscle receptor PMID: 18249103
    19. Betaig-h3 may play a critical role as a regulator of chondrogenic differentiation in endochondral ossification. PMID: 18779658
    20. Blocking of betaig-h3 expression in E12.5 embryos with antisense oligodeoxynucleotides resulted in cleft of the secondary palate PMID: 19415673

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  • 亚细胞定位：
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 组织特异性：
    Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus.
  • 数据库链接：

    KEGG: mmu:21810

    STRING: 10090.ENSMUSP00000037719

    UniGene: Mm.14455