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  4. Recombinant Mouse Transcription factor SOX-11 (Sox11)

Recombinant Mouse Transcription factor SOX-11 (Sox11)

  • 中文名称：
    小鼠Sox11重组蛋白
  • 货号：
    CSB-YP748750MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sox11重组蛋白
  • 货号：
    CSB-EP748750MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sox11重组蛋白
  • 货号：
    CSB-EP748750MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sox11重组蛋白
  • 货号：
    CSB-BP748750MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sox11重组蛋白
  • 货号：
    CSB-MP748750MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sox11; Sox-11; Transcription factor SOX-11
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-395
  • 氨基酸序列
    MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG PGKKCAKLKA PAGKAGAGKA AQPGDCAAGK AAKCVFLDDD DEDDDEDDEL QLRPKPDADD DDDEPAHSHL LPPPTQQQPP QLLRRYSVAK VPASPTLSSA AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD KDLDSFSEGS LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that acts as a transcriptional activator. Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation. Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron. Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis.
  • 基因功能参考文献：
    1. Data demonstrate a key role for SOX11 in normal kidney development and may suggest that variants in this gene predispose to CAKUT. PMID: 29459093
    2. SOX11 represents a useful prognostic marker in mantle cell lymphoma. PMID: 28429312
    3. Sox11 can induce substantial axon regeneration. Transcriptome profiling indicated that Sox11 activates genes involved in cytoskeletal remodeling and axon growth. Remarkably, alpha-RGCs, which preferentially regenerate following treatments such as Pten deletion, were killed by Sox11 overexpression. Thus, Sox11 promotes regeneration of non-alpha-RGCs, which are refractory to Pten deletion-induced regeneration. PMID: 28641110
    4. These findings indicate that suppression of dendritic morphogenesis by Sox11 during radial migration is crucial for the formation of the cerebral cortex. PMID: 27225767
    5. Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis PMID: 27241892
    6. Sox11 directly regulates the expression of Fgf9; ablation of the Sox11 gene results in clefting of the secondary palate resembling the Pierre Robin sequence. PMID: 26826126
    7. SOXC proteins act cell- and non-cell-autonomously in perichondrocytes and chondrocytes to establish noncanonical WNT signaling crosstalk essential for growth plate induction and control PMID: 25761772
    8. Sox11 and Sox4 are not redundant in promoting neuronal differentiation in the cortex, but rather act in overlapping and discrete populations of neurons PMID: 26203155
    9. Fetal Sox11 disruption lead to hypoplastic lungs, ventricular septation defects, abdominal defects, skeletal malformations, decreased birth weight and postnatal lethality. PMID: 24886874
    10. regulates osteogenesis PMID: 24722414
    11. These data identify Sox11 as a key transcription factor that can confer an elevated innate regenerative capacity to CNS neurons. PMID: 25698749
    12. Sox11 expression was high in fetal. PMID: 25234735
    13. Sox4 and Sox11 are required for proper development of cardiac neural crest cells. PMID: 24310815
    14. The expression of Sox11 is increased in the injured spinal cord. Sox11 expression is located in ependymal cells lining the central canal and in newly-generated neurons in the injured spinal cord. PMID: 24589730
    15. Sox11 is required for both embryonic and adult neurogenesis PMID: 23483698
    16. Sox11 plays a crucial role in the proliferation and survival of mesenchymal and osteoblast precursors by Tead2, and osteogenic differentiation by regulating Runx2 and Osterix. PMID: 23888050
    17. Data indicate that a complete loss of retinal ganglion cells (RGCs) was observed in Sox4/Sox11-null retinas, suggesting the two genes play similar roles in the development of RGCs. PMID: 23649630
    18. TANK is expressed in DRG neurons. TANK is increased by peripheral nerve injury. the regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor Sox11. PMID: 23201825
    19. This work implicates SOX11 as a potential regulator of GDF5 expression in joint maintenance and suggests a possible role in the pathogenesis of osteoarthritis PMID: 23356643
    20. Data suggest that levels of Sox11 decline in developing retina; levels of histone H3-acetylation and H3-lysine 4 trimethylation at Sox11 gene locus decline during retinal development but increase markedly in adult retina. PMID: 23313252
    21. The sequential expression of Sox11 and Sox4 during retinogenesis leads to the fine adjustment of retinal differentiation by helping to establish the competency of retinal progenitors. PMID: 23318640
    22. Sox11 modulates neocortical development by regulating the proliferation and neuronal differentiation of cortical intermediate precursors PMID: 22687574
    23. The results of this study indicted that cell type and contextual specificity of Sox11 in modulation of BDNF transcription. PMID: 22331573
    24. Sox11 represents a synergistic factor for WT1 in regulating the Wnt4 gene expression that is critical for nephrogenesis during kidney ontogeny. PMID: 22465478
    25. SoxC transcription factors Sox11 and Sox4 target the promoters of genes that are induced upon neuronal differentiation of adult neural stem cells (NSCs). PMID: 22378879
    26. The results of this study revealed a new functional linkage between Sox11 and Sprr1a in adult peripheral neuron regeneration. PMID: 22024412
    27. The results clearly showed a correlation between SOX11 level and cellular growth rate, which was dependent on autotaxin, as well as a direct relation between the level of SOX11 in tumorigenic cells and the growth rate of these tumors in NOD-SCID mice. PMID: 21880559
    28. genome-wide binding for Sox11, which have vital functions in ES cells, neural precursor cells (NPCs), and maturing neurons, respectively. (Sox11) PMID: 22085726
    29. Study show that the survival of neural and mesenchymal progenitor cells critically relies on the redundantly acting SoxC transcription factors Sox4, Sox11 and Sox12. PMID: 20596238
    30. Sox11 is a key regulator of sensory neuron development. PMID: 21117150
    31. Sox11 protein directly function as pro-survival factors during spinal cord development in neural cell types PMID: 20646169
    32. Sox11 is involved in the transcriptional regulation of specific gene expression in adult neurogenesis at the stage of the immature neuron. PMID: 19490090
    33. In the absence of both Sox4 and Sox11, sympathetic ganglia remained hypoplastic throughout embryogenesis because of consecutive proliferation and survival defects. PMID: 20147379
    34. The study reports spatio-temporally regulated Sox4 and Sox11 antisense transcripts in the brain, neural stem/progenitor cells and P19 cells, suggesting they have an important role in cerebral corticogenesis and neuronal/glial cell differentiation. PMID: 19799774
    35. SOX11 has a role in in tissue remodeling PMID: 15254231
    36. Data support the model that synergistic interactions between group B1/C SOX (SOX1/2/3, SOX11) and class III POU (Brn2)within the nucleus determine Nestin expression. PMID: 15456859
    37. Sox4 and Sox11 function redundantly with Sox12 and can compensate its loss during mouse development. PMID: 18505825
    38. These anatomical and expression data support an intrinsic role for Sox11 in events that underlie successful regeneration following peripheral nerve injury. PMID: 19133245

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expression prominent in the periventricular cells of the central nervous system, also observed in a wide range of tissues involved in epithelial-mesenchymal interactions.
  • 数据库链接：

    KEGG: mmu:20666

    STRING: 10090.ENSMUSP00000078070

    UniGene: Mm.41702