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  4. Recombinant Mouse Tether containing UBX domain for GLUT4 (Aspscr1)

Recombinant Mouse Tether containing UBX domain for GLUT4 (Aspscr1)

  • 中文名称：
    Recombinant Mouse Tether containing UBX domain for GLUT4(Aspscr1),Yeast
  • 货号：
    CSB-YP840822MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Tether containing UBX domain for GLUT4(Aspscr1),Yeast
  • 货号：
    CSB-EP840822MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Tether containing UBX domain for GLUT4(Aspscr1),Yeast
  • 货号：
    CSB-EP840822MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Tether containing UBX domain for GLUT4(Aspscr1),Yeast
  • 货号：
    CSB-BP840822MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Tether containing UBX domain for GLUT4(Aspscr1),Yeast
  • 货号：
    CSB-MP840822MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Aspscr1
  • Uniprot No.：
  • 别名：
    Aspscr1; TugTether containing UBX domain for GLUT4; Alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-550
  • 氨基酸序列
    AAPAGGGGS AVSVLAPNGR RHTVKVTPST VLLQVLEDTC RRQDFNPSEY DLKFQRTVLD LSLQWRFANL PNNAKLEMVP VSRSREGPEN IVRIAFQLDD GSRLQDAFCS RQTLWELLSH FAQTRERLQQ LGEKTPVCVY MRNEVTGRAA LQNTTLQSLG LTGGSATIRF VIKQCDTAGK QESIAVRSKA PGSPVSSLSA DQASSSTLLP LNSGEFSRGD LNHEGDANTS GTGLEGGPKP TDAQTKQSTS EPASAPFVPF SGGGQRLGGP SASLRPLTSP SANSSKSFSG PGGPSKPKKP KPGEEPQQEP EPPVDRDPVV YHPDLEDLLQ PWPAEVPDEF FEVTVDDVRR RLAQLKSERK RLEEAPLVTK AFREAQMKEK LERYPKVALR VLFPDRYILQ GFFRPSETVG DLRDFVRSHL GNPELSFYLF IAPPKMVLDD HTLTLFQANL FPAALVHFGA EEPTGLYLEP GLLEHTVSPS TADVLVARCM SRASGSPPLL PAPDPVSLES EPIAEDGALG PPEPIQGTAQ PVKRSLGKVP KWLKLPASKR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Enhances VCP methylation catalyzed by VCPKMT. Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface.
  • 基因功能参考文献：
    1. Insulin acts through TUG proteins to control IRAP targeting, similar to GLUT4; the activity of vasopressin, an IRAP substrate, is reduced in mice with disrupted TUG action in muscle. PMID: 25944897
    2. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile. PMID: 25453902
    3. Data indicate that insulin stimulates proteolysis of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4)) to translocate GLUT4 in muscle. PMID: 23744065
    4. Data suggest a model whereby insulin stimulates TUG cleavage to liberate GLUT4 storage vesicles from the Golgi matrix, which promotes GLUT4 translocation to the cell surface and enhances glucose uptake. PMID: 22610098
    5. TUG traps endocytosed GLUT4 and tethers it intracellularly, and insulin mobilizes this pool of retained GLUT4 by releasing this tether PMID: 14562105
    6. insulin-stimulated dissociation of TUG and GLUT4 as an important action by which insulin stimulates glucose uptake. PMID: 17202135

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  • 亚细胞定位：
    Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Cytoplasm. Nucleus.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:68938

    STRING: 10090.ENSMUSP00000026135

    UniGene: Mm.294020