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  4. Recombinant Mouse Pleckstrin homology-like domain family A member 2 (Phlda2)

Recombinant Mouse Pleckstrin homology-like domain family A member 2 (Phlda2)

  • 中文名称：
    小鼠Phlda2重组蛋白
  • 货号：
    CSB-YP017931MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Phlda2重组蛋白
  • 货号：
    CSB-EP017931MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Phlda2重组蛋白
  • 货号：
    CSB-EP017931MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Phlda2重组蛋白
  • 货号：
    CSB-BP017931MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Phlda2重组蛋白
  • 货号：
    CSB-MP017931MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Phlda2
  • Uniprot No.：
  • 别名：
    Phlda2; Ipl; Tssc3Pleckstrin homology-like domain family A member 2; Imprinted in placenta and liver protein; Protein 50C15
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-144
  • 氨基酸序列
    MASKIVMSSK TVKTSDEILC EGELEKRSDS LFQVWKKKRC VLTADRLRLF SGKTSPAKEL FFHSILKVDC VEHTSKYVYF TIVTNYYKEI DFRCTVESCW NAAITMALID FQNRRALQDF PRYRYQRSES EMPSEPGEQS ALGP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
  • 基因功能参考文献：
    1. Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth. PMID: 26476147
    2. data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve PMID: 25085993
    3. TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT/MASH2 signaling pathway. PMID: 23071113
    4. Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting. PMID: 15327781
    5. A critical role for the imprinted Phlda2 gene in regulating glycogen storage in the eutherian placenta is identified. PMID: 19884348
    6. deletion causes placental overgrowth PMID: 12032310
    7. Embryonic expression of Ipl in mice PMID: 12141432
    8. Ipl and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs. PMID: 12374806

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    PHLDA2 family
  • 组织特异性：
    Specifically expressed at high levels in extraembryonic tissues in the developing conceptus (at protein level). Expressed in placenta and yolc sac. Expressed at low levels in fetal liver and kidney.
  • 数据库链接：

    KEGG: mmu:22113

    STRING: 10090.ENSMUSP00000010904

    UniGene: Mm.334344